Protein Alignment Ir75a and grin2ca

DIOPT Version :10

• Sequence 1: NP_649012.2
• Gene: Ir75a / 39982
• FlyBaseID: FBgn0036757
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 718
• Identity: 147/718 - (20%)
• Similarity: 258/718 - (35%)
• Gaps: 211/718 - (29%)

  Fly    63 SHLELSY-MGHTQPTLAIYVDIKCDQTQDLLEEASREQI-------YNQH--------------- 104
            |.::.|| :...|.||..  |:..|...||......:||       |..|
Zfish   193 SFIDTSYFLWELQDTLTF--DMSADGMNDLRARRLLQQIDAQVLLVYCSHDEAQYLFSMAREVGL 255

  Fly   105 ----YHW----LLVGNQSKLEFYDLF--GLFNISIDADVSYVKEQIQDNNDSVAYAVHDV----- 154
                |.|    |.|||.: :...|.|  ||.:|..|.....::.:::   |.||..|..|
Zfish   256 VGPGYIWFIPSLAVGNPN-IAPPDSFPVGLISIITDRWKMSLRNRVR---DGVAIVVKGVESFRK 316

  Fly   155 ------------------YNNGKIIGGQLNVTGSH---EMSCDPFVCRRTRHLSSLQKR---SKY 195
                              .:||.:....|||:..:   ..:.|.::...:..:.:|.:.   .|.
Zfish   317 QRGFIPDGHMDCLSPIRPASNGTLYRHMLNVSWENTDFSFNSDGYLVNPSMIIITLDRGRQWDKV 381

  Fly   196 GNRE----QLTDVV----------------LRVATVVTQRPLT------------LSDDELIRFL 228
            ||.|    |:...|                |.||| :.:||..            ||:....|..
Zfish   382 GNYESGILQMRYPVWPRYGTFLEPVSDNRHLTVAT-LEERPFVIVEAVDPVTGTCLSNTVPCRRQ 445

  Fly   229 SQENDT---HIDSLARF---GFHLTLILRDLLHCKMKFIFSDSWSKSD---------VVGGSVGA 278
            |.:.:|   |.:...:.   ||.:.::.:  |...:||.: |.:..::         :..|.:|.
Zfish   446 SNKTETIVGHTEPYTKLCCKGFCIDILKK--LSRNIKFSY-DLYLVTNGKHGKLVRGIWNGMIGE 507

  Fly   279 VVDQTADLTATPSLATEGR---LKYLSAIIETGFFRSVCIFRTPHNAGLRGDVFLQPFSPLVW-Y 339
            |..:.||:........|.|   :.:....:|||.  ||.:.|:  |..:....||:|:||.|| .
Zfish   508 VFYKRADMAIGSLTINEERSEIIDFSVPFVETGI--SVMVARS--NGTVSPSAFLEPYSPAVWVM 568

  Fly   340 LFGGVLSLIGVLLWITFYMECKRMQKRWRLDYLPSLLS-------TFLIS------FGAACIQSS 391
            :|...|:::.|.:::..|  |.      .:.|..||:|       ||.|.      :|.....|.
Zfish   569 MFVMCLTVVAVTVFVFEY--CS------PVGYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSV 625

  Fly   392 SL-IPRSAGGRL--IYFALFLISFIMYNYYTSVVVSSLLSSPVKSKIKTMRQLAESS-------- 445
            .: .|:....::  :.:|.|.:.|:.  .||:.:.:.::.   :..|.|:..|::..
Zfish   626 PIENPKGTTSKIMVLVWAFFAVIFLA--SYTANLAAFMIQ---EQYIDTVSGLSDKKFQKPQDQY 685

  Fly   446 --LTVGLEPLPFTKSYLNYSRLPEIH----LFIKRKIESQTQNPELWLPAEQGVLRVRDNPGYVY 504
              ...|..|...|:..:. |..||:|    .:.::.:|....:           |:......::|
Zfish   686 PPFRFGTVPNGSTERNIR-SNYPEMHSHMVKYNQKGVEDALNS-----------LKTGKLDAFIY 738

  Fly   505 VFETSSGYAYVERYFTAQ-EICDLNEVLFRPEQLFYT-----HLHRNSTYKELFRLRFLRILETG 563
                   .|.|..|...: |.|.|  |.....::|.|     .|.:.|.:|....|..|:.|..|
Zfish   739 -------DAAVLNYMAGKDEGCKL--VTIGSGKVFATTGYGIALQKESRWKRPIDLALLQFLADG 794

  Fly   564 VYRKQRSYWVHMKLHCVAQN-----FVITVGMEYVAPLLLMLICADILVVVILLVE--LAWKRFF 621
            ..:|.::.|    |..:.:|     ....:.::.:|.:..||:.|..|.:::...|  |.||
Zfish   795 DTQKLQTVW----LTGICRNEKKEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWK--- 852

  Fly   622 TRH 624
            .||
Zfish   853 LRH 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75a	NP_649012.2	Periplasmic_Binding_Protein_Type_2	455..572	CDD:473866	25/126 (20%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	43/205 (21%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	91/446 (20%)
		NMDAR2_C	847..>938	CDD:463148	5/12 (42%)