DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cln3 and Cln3

DIOPT Version :9

Sequence 1:	NP_001261999.1	Gene:	Cln3 / 39981	FlyBaseID:	FBgn0036756	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001006972.1	Gene:	Cln3 / 293485	RGDID:	1359537	Length:	438	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	178/441 - (40%)
Similarity:	264/441 - (59%)	Gaps:	50/441 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QEAEAEHDPQVVVTPGDASRSSRQDRGLWRDLTSYWILGLCNNYGYVVMLSAAHDIIKQF----- 66
            :..|.:.:||   ||...:.|.     ||::...:||||||||:.|||||||||||:||.
  Rat    15 EREETDSEPQ---TPPLDNLSV-----LWKNAVGFWILGLCNNFSYVVMLSAAHDILKQEQASGN 71

  Fly    67 ------NPNDESEESSSGRNCHLVSTGAILLADVLPSLFVKI-------LMPFFPFWVNFRIALA 118
                  .|......|||..:|:.:||.|:||||:||:|.:|:       |:|:.|     |:.::
  Rat    72 QSHVEPGPTPMPHNSSSRFDCNSISTAAVLLADILPTLVIKLLAPLGLHLLPYSP-----RVLVS 131

  Fly   119 VAFSAAGFLLVGFANAEWMALLGVIITSASSGIGETTFLAYSSRYNKNVISTWSSGTGGAGVIGS 183
            ...||..|:||.|:.:..::|.||::.|.|||:||.|||:.::.|...|||.|||||||||::||
  Rat   132 GVCSAGSFVLVAFSQSVGLSLCGVVLASISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGS 196

  Fly   184 LSYASLRSLDFSPRDTMLIMLIFPAIEAFAFWLLLRRPQVDILPVTTVESTEVLISDEKPLVG-- 246
            |||..|.....||:.|:|.||..|.:...:::|||..|:    |:......|...:..:||:|
  Rat   197 LSYLGLTQAGLSPQHTLLSMLGIPVLMLASYFLLLTSPE----PLDPGGQDEAETAARQPLIGTE 257

  Fly   247 -------------FKEKLFYIKHLFKYMLPLCLVYFFEYFINQGLFELVYFEDIFLDKDSQYRWL 298
                         .:|:....|.|.:|::||.||||.|||||||||||::|.:..|....||||.
  Rat   258 TPESRPGTSWDLSLQERWTVFKGLLRYIIPLVLVYFAEYFINQGLFELLFFRNTSLSHAQQYRWY 322

  Fly   299 NVDYQIGVFISRSSVNLFQLDKIWLMSIFQFVNVVYFLTEVIWWYTPSIWIVFAIVLWEGLLGGG 363
            .:.||.|||.||||:...::...|::::.|.:|:.:.|.:|...:.|||:::|.::|:||||||.
  Rat   323 QMLYQAGVFASRSSLQCCRIRFTWILALLQCLNLAFLLADVCLTFLPSIYLIFIVILYEGLLGGA 387

  Fly   364 AYVNTFYRMSKEISPERQQFAMAMVVQSDSYGIALAGFLAIPVHNAICGLP 414
            ||||||:.::.|.|.:.::|||.....||:.||:|:|.||:|:|:.:|.||
  Rat   388 AYVNTFHNIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHLP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cln3	NP_001261999.1	CLN3	40..413	CDD:280623	168/405 (41%)
Cln3	NP_001006972.1	CLN3	40..437	CDD:396857	172/416 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3880
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37259
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2416
OMA	1	1.010	-	-		QHG54383
OrthoDB	1	1.010	-	-		D1037817at2759
OrthoFinder	1	1.000	-	-		FOG0004157
OrthoInspector	1	1.000	-	-		oto95725
orthoMCL	1	0.900	-	-		OOG6_102552
Panther	1	1.100	-	-	LDO	PTHR10981
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2906
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770