Protein Alignment CG5589 and ROK1

DIOPT Version :9

• Sequence 1: NP_649009.1
• Gene: CG5589 / 39979
• FlyBaseID: FBgn0036754
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_011344.1
• Gene: ROK1 / 852704
• SGDID: S000003139
• Length: 564
• Species: Saccharomyces cerevisiae
• Alignment Length: 619
• Identity: 225/619 - (36%)
• Similarity: 343/619 - (55%)
• Gaps: 93/619 - (15%)

  Fly     5 DIFKLITAGVRFTKKS------------------KKEPSSKQQLQPLPEVSKHEEPVKSEESDKD 51
            |||:::|.|....|:|                  .||.:::.|:....:..:::..:...|.|::
Yeast     2 DIFRVLTRGASVKKESGPKAKAADYSVINGNDENHKEDNNESQIVKELDFFRNKRIISKVEDDRE 66

  Fly    52 DEDITEFRLLDGDSSNQPKRK-------KPKKEKTLSPKELEIQKAAEEANETRKQYGIRVLGKN 109
                   :..:.||.|:.::.       ||....|:            ||:..||.|...|.|.:
Yeast    67 -------KTTENDSPNKEEKSGNDDGLIKPVITNTV------------EASALRKSYKGNVSGID 112

  Fly   110 VPPPVDSFGTLTRDFKMLPRLQQNLLSRNFDHPTPIQMQALPVLLQRRALMACAPTGSGKTLAFL 174
            :|.|:.||..|...|....||..||:...|..|||||.:.:||.|..|.::||.|||||||||||
Yeast   113 IPLPIGSFEDLISRFSFDKRLLNNLIENGFTEPTPIQCECIPVALNNRDVLACGPTGSGKTLAFL 177

  Fly   175 TPIINGLRAHK-TTGLRALVLAPTRELAQQIYRECAELT------RETGLRTHFISKVSEAKQKH 232
            .|::..:...| |.||:.|:::||:|||.||:.||.:|:      ::..|:...:||...||.|:
Yeast   178 IPLVQQIIDDKQTAGLKGLIISPTKELANQIFIECFKLSYKIFLEKKRPLQVALLSKSLGAKLKN 242

  Fly   233 GAECKQRYDILVSTPNRVRFLLQQEPPLLDLSHVEWFVLDEADRLMEEGQNNFKEQLDDIYAACS 297
            .....::|||::|||.|:..:::.|  .||||.|:..:.||||:|.::   .|.||.|||.:||.
Yeast   243 KVVSDKKYDIIISTPLRLIDVVKNE--ALDLSKVKHLIFDEADKLFDK---TFVEQSDDILSACR 302

  Fly   298 NPTKCVAFFSATYTVPVAKWALRHLKNLVRITIGVQNSATETVQQELLFVGSEGGKLVAIRDLVR 362
            .|:...|.||||....|.:.|...:.:.||:.||.:.:|...::|:|:|.|:|.|||:|||.||:
Yeast   303 EPSLRKAMFSATIPSNVEEIAQSIMMDPVRVIIGHKEAANTNIEQKLIFCGNEEGKLIAIRQLVQ 367

  Fly   363 QG-LQPPVLVFVQSKERAKQLFEELLYDGINVDVIHAERSQHQRDNCVKAFREGSIWVLICTELM 426
            :| .:||:::|::|..|||.|:.||:||.||||||||||:..|||..::.|:.|.:|.||||:::
Yeast   368 EGEFKPPIIIFLESITRAKALYHELMYDRINVDVIHAERTALQRDRIIERFKTGELWCLICTDVL 432

  Fly   427 GRGIDFKGVNLVINYDFPPTTISYIHRIGRTGRAGRPGRAITFFTQEDTSNLRGIALIIKNSGGT 491
            .|||||||||||||||.|.::.:|:||||||||.||.|:||||:|::|:..::.|..::|.||..
Yeast   433 ARGIDFKGVNLVINYDVPGSSQAYVHRIGRTGRGGRSGKAITFYTKQDSVAIKPIINVMKQSGCE 497

  Fly   492 VPEYMLQMKKVRKSEAKMRAKKPLDREDISTKIRPETKGDEKHKSTK-LKKVERTEKILKNRKGY 555
            |.|:|.:|.|:.:.|          :|.|        |..:.||..| :..|.:.:|..:.|
Yeast   498 VSEWMDKMAKMTRKE----------KESI--------KNGKAHKERKQITTVPKMDKAKRRR--- 541

  Fly   556 EKDLNSKQKKLGNIKTELKPAGKRKGNVEKKTKN 589
                          :.|:..|.||:.|.|...|:
Yeast   542 --------------QQEMIAASKRRKNEELSKKH 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5589	NP_649009.1	SrmB	87..594	CDD:223587	207/512 (40%)
		P-loop_NTPase	123..329	CDD:304359	86/212 (41%)
		HELICc	349..469	CDD:238034	72/120 (60%)
ROK1	NP_011344.1	SrmB	101..560	CDD:223587	204/498 (41%)
		DEADc_DDX52	133..336	CDD:350715	84/207 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344436
Domainoid	1	1.000	140	1.000	Domainoid score	I1032
eggNOG	1	0.900	-	-		E1_KOG0344
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5093
Inparanoid	1	1.050	366	1.000	Inparanoid score	I368
Isobase	1	0.950	-	0	Normalized mean entropy	S1012
OMA	1	1.010	-	-		QHG56500
OrthoFinder	1	1.000	-	-		FOG0003197
OrthoInspector	1	1.000	-	-		oto99479
orthoMCL	1	0.900	-	-		OOG6_102417
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1170
SonicParanoid	1	1.000	-	-		X3665
TreeFam	1	0.960	-	-
	16	15.740