Protein Alignment CG5589 and Ddx52

DIOPT Version :9

• Sequence 1: NP_649009.1
• Gene: CG5589 / 39979
• FlyBaseID: FBgn0036754
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_084372.2
• Gene: Ddx52 / 78394
• MGIID: 1925644
• Length: 598
• Species: Mus musculus
• Alignment Length: 639
• Identity: 281/639 - (43%)
• Similarity: 387/639 - (60%)
• Gaps: 101/639 - (15%)

  Fly     1 MDEHDIFKLITAGVRF-------------TKKSKKEPSSKQQLQPL------PEVSK-------H 39
            ||.:|:|:.:.||.:|             ..|.|.:..|.:.|:.|      ..||.       |
Mouse     1 MDSYDLFRRLGAGAKFDVKRFSADATRFQVGKRKFDSESLEVLKGLDFFGNKKSVSDECGALQIH 65

  Fly    40 EEPVKSEESDKDDEDITEFRLLDGDSSNQPKRKKPKK---------------------------- 76
            :||        .:|:.|:..||  :.|.:||:||.||
Mouse    66 QEP--------PNEEKTQGVLL--ERSKEPKKKKRKKMTSEVPAQEDFDGGIQWTSSVEAKLQDE 120

  Fly    77 ----EKTLSPKELE-IQKAAEEANETRKQYGIRVLGKNVPPPVDSFGTLTRDFKMLPRLQQNLLS 136
                ||.|:..:|| ::|  |:.|..|.::.|.|.|.::|.|:.:|..|.:::|:..||.||:|.
Mouse   121 KVSGEKKLTSGKLEHLRK--EKVNFFRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNILD 183

  Fly   137 RNFDHPTPIQMQALPVLLQRRALMACAPTGSGKTLAFLTPIINGLRAHKTTGLRALVLAPTRELA 201
            ..|..||||||||:||:|..|.|:|.|||||||||||..||:..|:.....|.||||::||||||
Mouse   184 AGFQVPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPTNKGFRALVISPTRELA 248

  Fly   202 QQIYRECAELTRETGLRTHFISKVSEAKQKHGAECKQRYDILVSTPNRVRFLLQQEPPLLDLSHV 266
            .||:||..:::..||.|.|.|.|.:.|.:|.|.:..:::||||:||||:.:||:|:||.:||::|
Mouse   249 SQIHRELIKISEGTGFRIHMIHKAAIAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLTNV 313

  Fly   267 EWFVLDEADRLMEEGQNNFKEQLDDIYAACSNPTKCVAFFSATYTVPVAKWALRHLKNLVRITIG 331
            ||.|:||:|:|.|:|:..|:|||..|:.||::|....|.||||:...|.:|...:|.|:|.::||
Mouse   314 EWLVVDESDKLFEDGKTGFREQLASIFLACTSPKVRRAMFSATFAYDVEQWCKLNLDNVVSVSIG 378

  Fly   332 VQNSATETVQQELLFVGSEGGKLVAIRDLVRQGLQPPVLVFVQSKERAKQLFEELLYDGINVDVI 396
            .:|||.|||:|||||||||.|||:|:|:||::|.:|||||||||.||||:||.||:|:|||||||
Mouse   379 ARNSAVETVEQELLFVGSETGKLLAMRELVKKGFKPPVLVFVQSIERAKELFHELIYEGINVDVI 443

  Fly   397 HAERSQHQRDNCVKAFREGSIWVLICTELMGRGIDFKGVNLVINYDFPPTTISYIHRIGRTGRAG 461
            ||||:|.||||.|.:||.|.|||||||.|:.|||||||||||||||||.:::.||||||||||||
Mouse   444 HAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAG 508

  Fly   462 RPGRAITFFTQEDTSNLRGIALIIKNSGGTVPEYMLQMKKVRKSEAKMRAKKPLDREDISTKIRP 526
            ..|:|:||||::|...||.:|.:|:.:|..||||:...:|:...:.|...||||:||.|.|
Mouse   509 NRGKAVTFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKLLSKQKKKMIKKPLERESICT---- 569

  Fly   527 ETKGDEKHKSTKLKKVERTEKILKNRKGYEKDLNSKQKKLGNIKTELKPAGKRK 580
                              |.|....:        :||||:....::.|...|.|
Mouse   570 ------------------TPKYFLEQ--------AKQKKVAGQNSKKKETLKEK 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5589	NP_649009.1	SrmB	87..594	CDD:223587	248/494 (50%)
		P-loop_NTPase	123..329	CDD:304359	102/205 (50%)
		HELICc	349..469	CDD:238034	87/119 (73%)
Ddx52	NP_084372.2	PRK11192	163..597	CDD:236877	238/463 (51%)
		Q motif	166..194		12/27 (44%)
		P-loop_NTPase	170..376	CDD:304359	102/205 (50%)
		DEAD box	319..322		2/2 (100%)
		Helicase_C	399..508	CDD:278689	81/108 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839845
Domainoid	1	1.000	184	1.000	Domainoid score	I3416
eggNOG	1	0.900	-	-		E1_KOG0344
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5093
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1012
OMA	1	1.010	-	-		QHG56500
OrthoDB	1	1.010	-	-		D400908at2759
OrthoFinder	1	1.000	-	-		FOG0003197
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102417
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1170
SonicParanoid	1	1.000	-	-		X3665
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790