Protein Alignment ais and Ddx52

DIOPT Version :10

• Sequence 1: NP_649009.1
• Gene: ais / 39979
• FlyBaseID: FBgn0036754
• Length: 594
• Species: Drosophila melanogaster
• Sequence 2: NP_084372.2
• Gene: Ddx52 / 78394
• MGIID: 1925644
• Length: 598
• Species: Mus musculus
• Alignment Length: 639
• Identity: 281/639 - (43%)
• Similarity: 387/639 - (60%)
• Gaps: 101/639 - (15%)

  Fly     1 MDEHDIFKLITAGVRF-------------TKKSKKEPSSKQQLQPL------PEVSK-------H 39
            ||.:|:|:.:.||.:|             ..|.|.:..|.:.|:.|      ..||.       |
Mouse     1 MDSYDLFRRLGAGAKFDVKRFSADATRFQVGKRKFDSESLEVLKGLDFFGNKKSVSDECGALQIH 65

  Fly    40 EEPVKSEESDKDDEDITEFRLLDGDSSNQPKRKKPKK---------------------------- 76
            :||        .:|:.|:..||  :.|.:||:||.||
Mouse    66 QEP--------PNEEKTQGVLL--ERSKEPKKKKRKKMTSEVPAQEDFDGGIQWTSSVEAKLQDE 120

  Fly    77 ----EKTLSPKELE-IQKAAEEANETRKQYGIRVLGKNVPPPVDSFGTLTRDFKMLPRLQQNLLS 136
                ||.|:..:|| ::|  |:.|..|.::.|.|.|.::|.|:.:|..|.:::|:..||.||:|.
Mouse   121 KVSGEKKLTSGKLEHLRK--EKVNFFRNKHKIHVQGTDLPDPIATFQQLDQEYKINSRLLQNILD 183

  Fly   137 RNFDHPTPIQMQALPVLLQRRALMACAPTGSGKTLAFLTPIINGLRAHKTTGLRALVLAPTRELA 201
            ..|..||||||||:||:|..|.|:|.|||||||||||..||:..|:.....|.||||::||||||
Mouse   184 AGFQVPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPTNKGFRALVISPTRELA 248

  Fly   202 QQIYRECAELTRETGLRTHFISKVSEAKQKHGAECKQRYDILVSTPNRVRFLLQQEPPLLDLSHV 266
            .||:||..:::..||.|.|.|.|.:.|.:|.|.:..:::||||:||||:.:||:|:||.:||::|
Mouse   249 SQIHRELIKISEGTGFRIHMIHKAAIAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLTNV 313

  Fly   267 EWFVLDEADRLMEEGQNNFKEQLDDIYAACSNPTKCVAFFSATYTVPVAKWALRHLKNLVRITIG 331
            ||.|:||:|:|.|:|:..|:|||..|:.||::|....|.||||:...|.:|...:|.|:|.::||
Mouse   314 EWLVVDESDKLFEDGKTGFREQLASIFLACTSPKVRRAMFSATFAYDVEQWCKLNLDNVVSVSIG 378

  Fly   332 VQNSATETVQQELLFVGSEGGKLVAIRDLVRQGLQPPVLVFVQSKERAKQLFEELLYDGINVDVI 396
            .:|||.|||:|||||||||.|||:|:|:||::|.:|||||||||.||||:||.||:|:|||||||
Mouse   379 ARNSAVETVEQELLFVGSETGKLLAMRELVKKGFKPPVLVFVQSIERAKELFHELIYEGINVDVI 443

  Fly   397 HAERSQHQRDNCVKAFREGSIWVLICTELMGRGIDFKGVNLVINYDFPPTTISYIHRIGRTGRAG 461
            ||||:|.||||.|.:||.|.|||||||.|:.|||||||||||||||||.:::.||||||||||||
Mouse   444 HAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAG 508

  Fly   462 RPGRAITFFTQEDTSNLRGIALIIKNSGGTVPEYMLQMKKVRKSEAKMRAKKPLDREDISTKIRP 526
            ..|:|:||||::|...||.:|.:|:.:|..||||:...:|:...:.|...||||:||.|.|
Mouse   509 NRGKAVTFFTEDDKPLLRSVANVIQQAGCPVPEYIKGFQKLLSKQKKKMIKKPLERESICT---- 569

  Fly   527 ETKGDEKHKSTKLKKVERTEKILKNRKGYEKDLNSKQKKLGNIKTELKPAGKRK 580
                              |.|....:        :||||:....::.|...|.|
Mouse   570 ------------------TPKYFLEQ--------AKQKKVAGQNSKKKETLKEK 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ais	NP_649009.1	SrmB	123..538	CDD:440279	228/414 (55%)
Ddx52	NP_084372.2	SrmB	163..534	CDD:440279	215/370 (58%)
		Q motif	166..194		12/27 (44%)
		DEAD box	319..322		2/2 (100%)