DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5589 and Ddx59

DIOPT Version :9

Sequence 1:	NP_649009.1	Gene:	CG5589 / 39979	FlyBaseID:	FBgn0036754	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001177749.1	Gene:	Ddx59 / 289402	RGDID:	1359520	Length:	619	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	182/571 - (31%)
Similarity:	270/571 - (47%)	Gaps:	73/571 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GVRFTKKSKKEPSSKQQLQPLPEVSKHEEPV-----KSEE--SDKDDEDITEFRLLDGDSSNQPK 70
            ||:.:..|::...|..:.|..||..   |||     :..|  .||.|||:.....       :.|
  Rat    80 GVKDSHPSEEPVKSFSKTQRWPEPG---EPVCVVCGRYGEYICDKTDEDVCSLEC-------KAK 134

  Fly    71 RKKPKKEKTLSPKELEIQKAAEEAN-----------------------ET-RKQYGIRVLGKNVP 111
            .....||:..|.|....|.||.|..                       || ::|.||.|.|:.|.
  Rat   135 HLLQVKEEEGSLKPSSPQGAASEPESPLDAFYVYKEHPFIVALRDDQIETLKQQLGISVQGQEVA 199

  Fly   112 PPVDSFGTLTRDFKMLPR-LQQNLLSRNFDHPTPIQMQALPVLLQRRALMACAPTGSGKTLAFLT 175
            .|:..|     :....|. |.|||....::.|||||||.:||.|..|.::|.|.||||||.|||.
  Rat   200 RPIIDF-----EHCGFPETLNQNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLL 259

  Fly   176 P-IINGLRAHKTTGLRALVLAPTRELAQQIYRECAELTRETGL----RTHFISKVSEAKQKHGAE 235
            | ||..|...||..  ||:|.||||||.||.|:..||.|  ||    ....:..:....|.:  .
  Rat   260 PVIIRALPEDKTPS--ALILTPTRELAIQIERQAKELMR--GLPRMKTVLLVGGLPLPPQLY--R 318

  Fly   236 CKQRYDILVSTPNRVRFLLQQEPPLLDLSHVEWFVLDEADRLMEEGQNNFKEQLDDIYAACSNPT 300
            .:|...::::||.|:..:::|..  :.||.::..|:||||.:::.|   |::|:.|:..  ..|:
  Rat   319 LQQHVKVVIATPGRLLDIIEQSS--VSLSGIKIVVVDEADTMLKMG---FQQQVLDVLE--HTPS 376

  Fly   301 KC-VAFFSATYTVPVAKWALRHLKNLVRITIGVQNSATETVQQELLFVGSEGGKLVAIRDLVRQG 364
            .| ....|||....:.:.|.:.|.|.|||..|.:|....:|:|.:|:|.....|......|..|.
  Rat   377 DCQTVLVSATIPDSIDQLADQLLHNPVRIVTGDKNLPCSSVRQIILWVEDPAKKKKLFEILNDQK 441

  Fly   365 L-QPPVLVFVQSKERAKQLFEEL-LYDGINVDVIHAERSQHQRDNCVKAFREGSIWVLICTELMG 427
            | :|||||||..|..|..|.|.: ...|::...||:|:||.:|...:|...||...|::.|.::|
  Rat   442 LFKPPVLVFVDCKLGADLLSEAVQKITGLSSTSIHSEKSQVERREILKGLLEGDYEVVVSTGILG 506

  Fly   428 RGIDFKGVNLVINYDFPPTTISYIHRIGRTGRAGRPGRAITFFTQEDTSNLRGIALIIKNSGGTV 492
            ||:|...|.||:|:|.|.:...|:|::||.||.|:.|.||||...........:|..:|.:|..:
  Rat   507 RGLDLVNVKLVVNFDMPSSLDEYVHQVGRVGRLGQNGTAITFINNNSKRLFWDVAKRVKPTGSIL 571

  Fly   493 PEYMLQMKKVRKSEAKMRAKKPLDREDISTKIRPETKGD--EKHKSTKLKK 541
            |..:|....:.:.:.|.:.|   ||:..|:.:......|  .||:.:..:|
  Rat   572 PPQLLNSPYLHEQKRKEQQK---DRQTQSSLVTGANLMDIIRKHEKSSSQK 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5589	NP_649009.1	SrmB	87..594	CDD:223587	161/490 (33%)
		P-loop_NTPase	123..329	CDD:304359	77/212 (36%)
		HELICc	349..469	CDD:238034	47/121 (39%)
Ddx59	NP_001177749.1	PLN00206	89..593	CDD:215103	172/534 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D400908at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010