DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and ABCA9

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001330984.1	Gene:	ABCA9 / 836295	AraportID:	AT5G61730	Length:	950	Species:	Arabidopsis thaliana

Alignment Length:	684	Identity:	188/684 - (27%)
Similarity:	299/684 - (43%)	Gaps:	120/684 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GDIKFP---PIKDLPSPPIFKSDNSSTLQDVGIMIIVIIIFFVVVSLTKSIVEEKELQLKVTLNL 100
            ||.||.   ..|:...|.|......|....:|.:..:....|..|....|:|.||||:|:..:..
plant   200 GDPKFSWDFGFKEFARPAIGGEVIISAFYLMGPVFFLAFSMFGFVLQLGSVVTEKELKLREAMTT 264

  Fly   101 MGVGSCLQWVAWYIQTFIIFLIGSSIITLF-----WKLVLPNSEISFMPFTHWSMALFVLLVLSH 160
            |||.....|::|.|...|:..:.|..:.||     ::..|.||.:          .:|:|..|..
plant   265 MGVYESAYWLSWLIWEGILTFVSSLFLVLFGMMFQFEFFLKNSFV----------LVFLLFFLFQ 319

  Fly   161 CT-ICFSFLMSSLISTTYRISLVTFLALIATYLPFLIL-----HSKGCSEGLNVFLSLF----LL 215
            .. |..:|.:||:||.:...:.|.||..:..::..::.     :|...|.|..|..|||    ..
plant   320 FNMIGLAFALSSIISKSSSATTVGFLVFLVGFITQIVTTAGFPYSSAYSIGSRVIWSLFPPNTFS 384

  Fly   216 SGLQVLVVGICMWEDYGEGLQWGNLFETSWPGG----TLSVGYILLVMILASFLSLLLCLYLEKI 276
            :|||:|:.......|  .|:.|..  .....||    .::...|.:.::...|...:|.||.:.|
plant   385 AGLQLLLEATSSPGD--SGISWSE--RAICAGGESTCVITTNKIYIWLVGTFFFWFVLALYFDNI 445

  Fly   277 RPGPYGV---------PQPWHFPCTR-----------CCSTESLLPYSRLFNRIFGIYSAAPDEE 321
            .|...||         |..|    |.           |....|:.|...:          .|::|
plant   446 IPNASGVRKSIFYFLKPSYW----TGKEGNKVEEGSICSCIGSVPPVEHI----------TPEDE 496

  Fly   322 RPDLQLIEPD----------PVDKIAGVQIRGLSKTF--------------GKMEVVKNVSFDMF 362
                .::|.:          .||....|||.||:||:              .....||.:..::.
plant   497 ----DVLEEEILVKQQAMDGRVDPNIAVQIHGLAKTYPGTTKLGCCKCTKTSPFHAVKGLWMNIA 557

  Fly   363 EGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQE--RRQAQRCIGLCPQQNVLFKH 425
            :.|:..|:|.|||||||.||.|.|....|.|.|.|.|..||..  ....::.||:|||.::|:..
plant   558 KDQLFCLLGPNGAGKTTTISCLTGINPVTGGDAKIYGNSIRSSVGMSNIRKMIGVCPQFDILWDA 622

  Fly   426 LSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKV 490
            |||..|:.||:.::||..:.:||..:..|..:.|....::.|.:.|||.:||||||.:|.|..|:
plant   623 LSSEEHLHLFASIKGLPPSSIKSIAEKLLVDVKLTGSAKIRAGSYSGGMKRRLSVAIALIGDPKL 687

  Fly   491 LICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFL 555
            :..|||:||:||..||.:|.:|.|:|:|..|:||||.:::.::|.||:.|::.|:|||||:...|
plant   688 VFLDEPTTGMDPITRRHVWDIIQESKKGRAIILTTHSMEEADILSDRIGIMAKGRLRCIGTSIRL 752

  Fly   556 KKQVDASCLITC-----------EARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSK 609
            |.:.....:.|.           |..||...|:|         .::|.......:.:.:|..|.:
plant   753 KSRFGTGFVATVSFIENKKDGAPEPLKRFFKERL---------KVEPTEENKAFMTFVIPHDKEQ 808

  Fly   610 YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMS 643
            .....|.:|:.:.:..|:....|...:|||:|::
plant   809 LLKGFFAELQDRESEFGIADIQLGLATLEEVFLN 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	109/333 (33%)
		ABC_subfamily_A	339..556	CDD:213230	90/232 (39%)
		ABC2_membrane_3	<821..1018	CDD:289468
		CcmA	1135..1450	CDD:224054
		ABC_subfamily_A	1136..1354	CDD:213230
ABCA9	NP_001330984.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2373
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820