Protein Alignment CG42816 and ABCA1

DIOPT Version :9

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_850354.2
• Gene: ABCA1 / 818768
• AraportID: AT2G41700
• Length: 1882
• Species: Arabidopsis thaliana
• Alignment Length: 1748
• Identity: 434/1748 - (24%)
• Similarity: 734/1748 - (41%)
• Gaps: 388/1748 - (22%)

  Fly    13 TGFLAVQQALSQ--VHIKHKCKEFNKTQGDIK-----------FPP--IKDLPSPPIFKSDN--S 60
            :|||.:||.:..  :....:..:...:..::.           |.|  |:.:|.|....:|:  .
plant   208 SGFLTLQQVVDSFIIFASQQNNDLPLSHSNLSSALRFELPWTLFSPSVIRMVPFPTREYTDDEFQ 272

  Fly    61 STLQDVGIMIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSS 125
            |.::.|..::.::...|.:..|....|.|||.:::..|.:||:...:..::|:|...:.|.:.|.
plant   273 SIVKSVMGLLYLLGFLFPISRLISYSVFEKEQKIREGLYMMGLKDEIFHLSWFITYALQFALCSG 337

  Fly   126 IITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLIS---TTYRISLVTFLAL 187
            |||......|.......:.||:     |.|..||  .|..||::|:..:   |...:..:|||
plant   338 IITACTMGSLFKYSDKTLVFTY-----FFLFGLS--AIMLSFMISTFFTRAKTAVAVGTLTFL-- 393

  Fly   188 IATYLPFLILHSKGCSEGLNVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSV 252
             ..:.|:..::.:..|..|.|..||...:...:..:....:|....||:|.|::..|   ..:|.
plant   394 -GAFFPYYTVNDESVSMVLKVVASLLSPTAFALGSINFADYERAHVGLRWSNIWRAS---SGVSF 454

  Fly   253 GYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIYSAA 317
            ...||:|:|.|.|...|.|||:|:.|...||..||:|..::....:.    :.|.|||.|..:
plant   455 FVCLLMMLLDSILYCALGLYLDKVLPRENGVRYPWNFIFSKYFGRKK----NNLQNRIPGFET-- 513

  Fly   318 PDEERPDLQLIEPDPVDKI---------------AGVQIRGLSKTF----GKMEVVKNVSFDMFE 363
             |....|:::.:.:|.|.:               ..:|:|.|.|.:    |....|.::...::|
plant   514 -DMFPADIEVNQGEPFDPVFESISLEMRQQELDGRCIQVRNLHKVYASRRGNCCAVNSLQLTLYE 577

  Fly   364 GQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSS 428
            .||..|:|||||||:|.||||.|.:.||||.|||.|..|.....:.::.:|:|||.::||..|:.
plant   578 NQILSLLGHNGAGKSTTISMLVGLLPPTSGDALILGNSIITNMDEIRKELGVCPQHDILFPELTV 642

  Fly   429 VSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLIC 493
            ..|:::|:.|:|:....:||.|.:..:::.|.:|.....|.||||.:|:||:..:|.|..||:|.
plant   643 REHLEMFAVLKGVEEGSLKSTVVDMAEEVGLSDKINTLVRALSGGMKRKLSLGIALIGNSKVIIL 707

  Fly   494 DEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQ 558
            |||::|:||.:.|..|:||.:.|:|..||||||.:|:.|.||||:.|:::|.|:|.||..|||..
plant   708 DEPTSGMDPYSMRLTWQLIKKIKKGRIILLTTHSMDEAEELGDRIGIMANGSLKCCGSSIFLKHH 772

  Fly   559 VDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQM- 622
            ......:|. .:....:.....::.||:.:....|..|.::.:||||:....|.::||::||.|
plant   773 YGVGYTLTL-VKTSPTVSVAAHIVHRHIPSATCVSEVGNEISFKLPLASLPCFENMFREIESCMK 836

  Fly   623 --------------NILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDDD----- 668
                          :..|::.:.:|..:|||:|:.....:|           |.:|:.:|
plant   837 NSVDRSKISEIEDSDYPGIQSYGISVTTLEEVFLRVAGCNL-----------DIEDKQEDIFVSP 890

  Fly   669 ------------EENEVQDGNVRSCK-------------------KQW----------------- 685
                        :::.:|...:.||.                   ..|
plant   891 DTKSSLVCIGSNQKSSMQPKLLASCNDGAGVIITSVAKAFRLIVAAVWTLIGFISIQCCGCSIIS 955

  Fly   686 RAMMTKKVMALY---------DNKVYFLLLLLTPIVYYITTLMMATKPHHSGRPTFNISDY---- 737
            |:|..:...||:         |.|......::..:......|.:..|||...:.....:.|
plant   956 RSMFWRHCKALFIKRARSACRDRKTVAFQFIIPAVFLLFGLLFLQLKPHPDQKSITLTTAYFNPL 1020

  Fly   738 -----GVDKFTILLSVPVSK-----------------SY----TEERRADSI--ASLIKGKLKLI 774
                 |.......||||::|                 ||    .:|..||:|  |....|. .|:
plant  1021 LSGKGGGGPIPFDLSVPIAKEVAQYIEGGWIQPLRNTSYKFPNPKEALADAIDAAGPTLGP-TLL 1084

  Fly   775 VVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYV--HAAPMILNLVYNALA 837
            .:||.:....|..::||.|       |:.:|.....|.:|:....:..  ||.|:.:|:::.|:.
plant  1085 SMSEFLMSSFDQSYQSRYG-------SILMDGQHPDGSLGYTVLHNGTCQHAGPIYINVMHAAIL 1142

  Fly   838 QELIGPK-ISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMII----------FSSAVIQ 891
            :...|.| ::|:..:.|....|.:..   ...|:..:     |.|:|:          |:..:::
plant  1143 RLATGNKNMTIQTRNHPLPPTKTQRI---QRHDLDAF-----SAAIIVNIAFSFIPASFAVPIVK 1199

  Fly   892 ERVSHMKMLQEVSGLEMITYWLSHLAFDMVVF-FILVLALLL-------PLYGYAPWYLLLCVLF 948
            ||....|..|.:||:.:::||||...:|.:.| |....|::|       ...|...:...:.:|.
plant  1200 EREVKAKHQQLISGVSVLSYWLSTYVWDFISFLFPSTFAIILFYAFGLEQFIGIGRFLPTVLMLL 1264

  Fly   949 FTGLAGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMILG-ALALIFKMVYVAIYVANMHPLI 1012
            ..|||.....|.|....:...:|.::||:......||||::. .:.||........|:.|...|.
plant  1265 EYGLAIASSTYCLTFFFTEHSMAQNVILMVHFFSGLILMVISFVMGLIPATASANSYLKNFFRLS 1329

  Fly  1013 AGYNCIQKCFHYMSLC--GSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWPDMLVM 1075
            .|: |.......::|.  |.....:......|:|...      :.:|....:..       .||.
plant  1330 PGF-CFSDGLASLALLRQGMKDKSSHGVFEWNVTGAS------ICYLGLESIFY-------FLVT 1380

  Fly  1076 LGTAIILFLLIMFFEYGSCVWYRCK----GCCPYSSKGSIEDP--KVSREAEKIRAMDADQIGTR 1134
            ||..::....:|.|..|.. |...|    |....|::..::|.  .:|.:.|.    |.|....|
plant  1381 LGLELMPVQKVMSFSIGEW-WQNLKAFKQGAGSSSTEPLLKDSTGAISTDMED----DIDVQEER 1440

  Fly  1135 ALVVNGVS-----------KKYGCD-----QLAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIV 1183
            ..|::|:|           |.|..|     ::||.:::|:::...|.|.||.||||||||..|:.
plant  1441 DRVISGLSDNTMLYLQNLRKVYPGDKHHGPKVAVQSLTFSVQAGECFGFLGTNGAGKTTTLSMLS 1505

  Fly  1184 GEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDL-NKR 1247
            ||.:...|..:|.|..:........:.:|||||.|:.||:||.::.|:::..|.|.....: |..
plant  1506 GEETPTSGTAFIFGKDIVASPKAIRQHIGYCPQFDALFEYLTVKEHLELYARIKGVVDHRIDNVV 1570

  Fly  1248 CEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINE 1311
            .|||. :|...||..|.....|||.|||::.|:| .|...::.|||||.|:||.::|.:|.:|:.
plant  1571 TEKLV-EFDLLKHSHKPSFTLSGGNKRKLSVAIAMIGDPPIVILDEPSTGMDPVAKRFMWDVISR 1634

  Fly  1312 VA-QQGK-AVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKL----VVNVQ 1370
            :: :.|| ||:||:|:|:|..|||::..|:|.|.:..:||.||:|.:....:.|::    |.||:
plant  1635 LSTRSGKTAVILTTHSMNEAQALCTRIGIMVGGRLRCIGSPQHLKTRYGNHLELEVKPNEVSNVE 1699

  Fly  1371 PDN------------------------------------------------MVAMLTKI------ 1381
            .:|                                                ||..:.|.
plant  1700 LENFCQIIQQWLFNVPTQPRSLLGDLEVCIGVSDSITPDTASASEISLSPEMVQRIAKFLGNEQR 1764

  Fly  1382 ---------EDD--------------------------------------IYMTYPNAELKE--- 1396
                     |:|                                      |..::|.|..|.
plant  1765 VSTLVPPLPEEDVRFDDQLSEQLFRDGGIPLPIFAEWWLTKEKFSALDSFIQSSFPGATFKSCNG 1829

  Fly  1397 ---KYEF---SGRLTFQISKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIA 1448
               ||:.   .|.|        |.::.|.::|.||:...:.:||:||.:||..|...|
plant  1830 LSIKYQLPFGEGGL--------SLADAFGHLERNRNRLGIAEYSISQSTLETIFNHFA 1879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	115/340 (34%)
		ABC_subfamily_A	339..556	CDD:213230	92/220 (42%)
		ABC2_membrane_3	<821..1018	CDD:289468	50/218 (23%)
		CcmA	1135..1450	CDD:224054	119/448 (27%)
		ABC_subfamily_A	1136..1354	CDD:213230	87/237 (37%)
ABCA1	NP_850354.2	ABC2_membrane_3	<290..474	CDD:289468	50/196 (26%)
		ABC_subfamily_A	549..770	CDD:213230	92/220 (42%)
		drrA	556..874	CDD:130256	112/318 (35%)
		ABC2_membrane_3	<1118..1381	CDD:289468	58/284 (20%)
		Zinc_peptidase_like	<1215..1382	CDD:301362	37/180 (21%)
		EcfA2	1450..1676	CDD:224047	82/226 (36%)
		ABC_subfamily_A	1453..1679	CDD:213230	84/226 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	144	1.000	Domainoid score	I1483
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm2678
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830