DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42816 and abcg4b

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001104682.1	Gene:	abcg4b / 794238	ZFINID:	ZDB-GENE-080215-10	Length:	644	Species:	Danio rerio

Alignment Length:	818	Identity:	165/818 - (20%)
Similarity:	274/818 - (33%)	Gaps:	312/818 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 ETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFP-CTRCCSTESLLPYSR 305
            :||.| |::|:|           :...||          .|..||...| .|.....|:.:..::
Zfish     4 KTSDP-GSVSIG-----------MEESLC----------NGGSQPQEAPLLTHLKKVENHITEAQ 46

  Fly   306 LFNRIFGIYSAAPDEERPDLQL------IEPDPVDKIAGVQ--IRGLSKTFGKMEVVKNVSFDMF 362
            .|:.:       |.....:|:.      |...|..|..|.:  ::.||..|...|::.
Zfish    47 RFSHL-------PKRTTVELEFKELCYTIREGPWWKKQGYKALLKCLSGKFSSRELIG------- 97

  Fly   363 EGQITVLMGHNGAGKTTLISMLAGF-ISPTSGTALINGFDIRQERR-QAQRCIGLCPQQNVLFKH 425
                  :||.:||||:||:::|||: .:..:|..|:|| .:|..|. :...|..:  |::.|..|
Zfish    98 ------IMGPSGAGKSTLMNILAGYRETGMTGQILVNG-KLRDPRTFRKMSCYIM--QEDKLLPH 153

  Fly   426 LSSVSHIQLFSRLRGLRGAEVKSE-VQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVK 489
            ||....:.:.:.|:....:|||.| ::..|..|.|.|.......:||||..:||::|..|.....
Zfish   154 LSVQEAMMVSANLKLNESSEVKKELIKEILTALGLHECVHTRTVSLSGGQCKRLAIALELVNNPP 218

  Fly   490 VLICDEPSTGLDPSARRELWRLILE-AKEGCTILLTTHQ----LDDGEVLGDRVVIISDGQLRCI 549
            |:..|||::|||.::..::..|:.. |:.|.||:.|.||    |.:   :.|::.|:|.||  ||
Zfish   219 VMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFE---MFDKLYILSQGQ--CI 278

  Fly   550 --GSLPFLKKQV------------DASCLI---------------------TCEARKRC---DLE 576
              ||:|:|...:            .|..:|                     .|...::|   |..
Zfish   279 YKGSVPYLIPYLRGLGLHCPTYHNPADFIIEVASGEYGDLNPVLFEAVQGGMCALEEKCNCIDKT 343

  Fly   577 KLTSLISR------HV-------GTIQPFSIKGR----DVCYKLPLSKSKYFS------------ 612
            .:||..::      ||       .::..|.|..:    .:|....|:..:..|
Zfish   344 TVTSCAAKCVKDPGHVESHTFATSSLTQFCILFKRTFITICRDQVLTHLRLMSHISIGVLIGLLY 408

  Fly   613 -SLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGA-----------------EDLNSRQSGGAEK 659
             ::..|.....|..|...||:       :|:.|||                 |.||
Zfish   409 LNIGNDASKVFNNTGFLFFSM-------LFLMFGALMPTVLTFPLEMAVFLREHLN--------- 457

  Fly   660 RDDDDRDDDEENEVQDGNVRSCKKQWRAMMTKKVMALYDNKVYFL--------LLLLTPIVYYIT 716
                                    .|           |..|.|:|        ..:|.||:|...
Zfish   458 ------------------------YW-----------YSLKAYYLAKTMADIPFQVLCPIMYCSI 487

  Fly   717 TLMMATKPHHSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIK 781
            ...|..:|..:.|            :.:.|::.:            ..:|:...|.|:|.:..
Zfish   488 VYWMTEQPPEASR------------YLLFLALSI------------CTALVAQSLGLLVGAAS-- 526

  Fly   782 DYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELIGPKIS 846
                              .|:.:.|        :|||
Zfish   527 ------------------TSLQVAT--------FVGP---------------------------- 537

  Fly   847 IEVTSVPFTLRKKEDFLISNNGDIPIYV--IGYVSIAMIIFSSAVIQ------------ERVSHM 897
              ||.:|..|  ...|.: |...||.|:  ..|||.....|...::.            .||...
Zfish   538 --VTGIPVLL--FSGFFV-NFDTIPEYLQWSSYVSYVRYGFEEVILSIYGMNRTERECPGRVCKF 597

  Fly   898 KMLQEVSGLEMITYWLSHLAFDMVVFFILVLALLLPLY 935
            :..:||  |:::....:.|..|.:|..|..:.|.|..|
Zfish   598 QRPEEV--LQLLDVEDAKLYMDFIVLGIFFVILRLATY 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	92/384 (24%)
		ABC_subfamily_A	339..556	CDD:213230	70/228 (31%)
		ABC2_membrane_3	<821..1018	CDD:289468	25/129 (19%)
		CcmA	1135..1450	CDD:224054
		ABC_subfamily_A	1136..1354	CDD:213230
abcg4b	NP_001104682.1	3a01204	42..644	CDD:273361	151/758 (20%)
		ABCG_EPDR	57..281	CDD:213180	72/244 (30%)
		ABC2_membrane	375..574	CDD:279410	49/334 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000