DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca2

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_006233707.2	Gene:	Abca2 / 79248	RGDID:	620238	Length:	2435	Species:	Rattus norvegicus

Alignment Length:	1815	Identity:	432/1815 - (23%)
Similarity:	756/1815 - (41%)	Gaps:	466/1815 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YPLYKTGFLAVQQALSQVHIKHKCKEFNKTQG-DIKFPP--IKDLPSPPIFKSDNSSTLQDVGIM 69
            |.||  ||:.:|..:.:..|       |...| |:..|.  ::..|.|...:.|....::.:..:
  Rat   655 YFLY--GFVWIQDMIERAII-------NTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPL 710

  Fly    70 IIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKL- 133
            .:||...:.|....:.||.|||.:||..:..||:.:.:.||||:|..|:...|..:.:|...|.
  Rat   711 CMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG 775

  Fly   134 -VLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFL-- 195
             ||.:|.:..:    |   || |.|.:..||.|.||:|.|.|.....|....:....:|:|::
  Rat   776 QVLMHSHVLII----W---LF-LAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYV 832

  Fly   196 -----ILHSKGCSEGLNVFLSLF---LLSGLQVLVVGI-----CMWEDYGEGLQWGNLFETSWPG 247
                 :.|.|         ::.|   :.|.:.....|:     .::|..|.|:||....::...|
  Rat   833 AIREEVAHDK---------ITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEG 888

  Fly   248 GTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTR------------------- 293
            ...::...:.::::.:.:..:|..|:|.:.||.||:|:||:||..:
  Rat   889 DDFNLLLAVTMLMVDTVVYGVLTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTETWEWSWPWA 953

  Fly   294 ------------CCSTESLLPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQIRGLSK 346
                        .|:.|     ||.|....|:     :||...|.|:.  .|||        |:|
  Rat   954 HAPRLSVMEEDQACAME-----SRHFEETRGM-----EEEPTHLPLVV--CVDK--------LTK 998

  Fly   347 TF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQA 409
            .:  .|...:..:|.:::|.|:...:|||||||||.:|:|.|...||||:|.|.|.|||.|..:.
  Rat   999 VYKNDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMDEI 1063

  Fly   410 QRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGT 474
            ::.:|:|||.||||..|:...|:..:|||:.:...|::.|:...::.|.|..|:....:.||||.
  Rat  1064 RKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSMAQEEIRKEMDKMIEDLELSNKRHSLVQTLSGGM 1128

  Fly   475 QRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVV 539
            :|:||||.:..||.:.:|.|||:.|:||.|||.:|.|||:.|.|.||||:||.:|:.::||||:.
  Rat  1129 KRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGDRIA 1193

  Fly   540 IISDGQLRCIGSLPFLKKQVDASCLITCEAR----------------------KRCDLEKLTSLI 582
            |||.|:|:|.||..|||........:|...|                      ..|...:::..|
  Rat  1194 IISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPSGRPQLSNCSEMQVSQFI 1258

  Fly   583 SRHVGTIQPFSIKGRDVCYKLPLS--KSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFG 645
            .:||.:....|....::.|.||..  |...|..||:.||..::.|.:..|.|...:|||:|:...
  Rat  1259 RKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVS 1323

  Fly   646 AED----------------------------------------------LNSRQSGGAEKRDD-- 662
            .||                                              |.|..|.|:.:.|:
  Rat  1324 EEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQASLQSASSVGSARGDEGA 1388

  Fly   663 -------------DDRDDDEENEVQDGNVRSC----------------KKQWRAMMTKKVMALYD 698
                         |:..|.:...:|:..:.:.                .:|:..::.|:......
  Rat  1389 GYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGWWLKMRQFHGLLVKRFHCARR 1453

  Fly   699 NK----------VYFLLLLLT-----PIVYYITTLMMATKPHHS-GRPTFNISDYG--------- 738
            |.          .:|:.:.:|     |.:..:..|:::...:|: .:|..|...|.
  Rat  1454 NSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERREYRL 1518

  Fly   739 -----------VDKF--------TILLSVPVS---------------------------KSYTE- 756
                       |..|        |.:|..|.:                           :|:|:
  Rat  1519 RLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRLLAARFFDSMCLESFTQG 1583

  Fly   757 --------------------ERRADSIAS------------------------------------ 765
                                ....||:.:
  Rat  1584 LPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNTSLPPTAGPETWTWAPSLPRLVHEPVRCTCSAQG 1648

  Fly   766 -----------------LIKGKLKLIVVSEQIKDYV---DDKWK-SREGRREINFVSMAIDT--G 807
                             ::.|.:...:....:.:|:   .|::: .|.|......:..:|..  |
  Rat  1649 TGFSCPSSVGGHPPQMRVVTGDILTDITGHNVSEYLLFTSDRFRLHRYGAITFGNIQKSIPAPIG 1713

  Fly   808 DRTGL-IGWVGPRHYV---------HAAPMILNLVYNALAQELIGPK-------ISIEVTSVPFT 855
            .||.| :..:..|...         |:.|..||.:.||:.:..: ||       ..|.||:.|..
  Rat  1714 TRTPLMVRKIAVRRVAQVLYNNKGYHSMPTYLNSLNNAILRANL-PKSKGNPAAYGITVTNHPMN 1777

  Fly   856 LRKKE---DFLISNNG-DIPIYVI---GYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWL 913
            .....   |:|:.... .|.|::|   .:|..:.::|   ::.|:.:..|.||.|||...:.|||
  Rat  1778 KTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVF---LVAEKSTKAKHLQFVSGCNPVIYWL 1839

  Fly   914 SHLAFDMVVFFI-----LVLALLLPLYGYA-----PWYLLLCVLFFTGLAGLIF-IYFLISMLSA 967
            ::..:||:.:.:     :::..:..|..|.     |..|.|.:|:...:..::: ..|...:.|:
  Rat  1840 ANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSS 1904

  Fly   968 TFLAVSMILLSVIIGSLILMILGALALIFK----MVYVAIYVANMHPLIAGYN----CIQKCFHY 1024
            .:  |.:|::::.|| :...:...|..:|:    :..|..|:.:...:...||    .::..::
  Rat  1905 AY--VFLIVINLFIG-ITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLGHGLMEMAYN- 1965

  Fly  1025 MSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAIILFLL 1085
                 .||:|....:.:   .|:|               .:|..|.    .::.|.....:.|.|
  Rat  1966 -----EYINEYYAKIGQ---FDKM---------------KSPFEWDIVTRGLVAMTVEGFVGFFL 2007

  Fly  1086 IMFFEYGSCVWYRCKGCCPYSSKGSIEDPKVSREAEKIRAMDADQIGTRALVVNGVSKKYGCDQ- 1149
            .:..:|.   :.|.....|.|:|...:|..|:.|.:::...|||   ...:.:..::|.|...:
  Rat  2008 TIMCQYN---FLRQPQRLPVSTKPVEDDVDVASERQRVLRGDAD---NDMVKIENLTKVYKSRKI 2066

  Fly  1150 ---LAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKEL 1211
               |||:.:...::|..|.||||.||||||:||||:.|:.|...|..:::|:|:.....:..:.|
  Rat  2067 GRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSL 2131

  Fly  1212 GYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKI 1276
            |||||.|:.|:.||.|:.|:::..:.|.|.||..:......::....|..||....||||.|||:
  Rat  2132 GYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALEKLELTKCADKPAGSYSGGNKRKL 2196

  Fly  1277 NAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILV 1340
            :.|:| .|..:.|.||||:.|:||.:||.:|.:|.::.:.|::|:||||:|:|..|:|::..|:|
  Rat  2197 STAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSHSMEECEAVCTRLAIMV 2261

  Fly  1341 DGSIYAMGSVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDI-------YMTYPNAELKEKY 1398
            :|.:..:||:||:||:...|.            |:.:.||...::       ...:|.|.|||::
  Rat  2262 NGRLRCLGSIQHLKNRFGDGY------------MITVRTKSSQNVKDVVRFFNRNFPEAMLKERH 2314

  Fly  1399 EFSGRLTFQI-SKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKSN 1457
            .  .::.:|: |:..|.:::|..:|.......:||||:||.:|::.|...|    ||:|:
  Rat  2315 H--TKVQYQLKSEHISLAQVFSKMEHVVGVLGIEDYSVSQTTLDNVFVNFA----KKQSD 2368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	119/332 (36%)
		ABC_subfamily_A	339..556	CDD:213230	94/218 (43%)
		ABC2_membrane_3	<821..1018	CDD:289468	49/238 (21%)
		CcmA	1135..1450	CDD:224054	109/327 (33%)
		ABC_subfamily_A	1136..1354	CDD:213230	84/222 (38%)
Abca2	XP_006233707.2	rim_protein	1..2369	CDD:130324	432/1815 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4008
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730