DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca6

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_671751.2	Gene:	Abca6 / 76184	MGIID:	1923434	Length:	1624	Species:	Mus musculus

Alignment Length:	1576	Identity:	398/1576 - (25%)
Similarity:	709/1576 - (44%)	Gaps:	281/1576 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YKTGFLAVQQALS----QVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMII 71
            ::.||:|:|.|::    :|...|...|...:...|.   :|.||..|       ..|.|..|.|:
Mouse   171 WERGFVALQTAINAGIIEVTTNHSVMEELMSIDGIN---MKTLPFIP-------RDLSDYEIFIL 225

  Fly    72 VIIIFF-VVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVL 135
            ..:::| ..:....|.|.::..|.|..:.:||:.....|::|.: .::.|:.   ||::|..:::
Mouse   226 FCLLYFSSFIYFASSNVTKERKQCKEVMKVMGLQDSAFWLSWGL-IYVGFIF---IISIFIAIII 286

  Fly   136 PNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISL-VTFLALIATYLPFLILHS 199
            .:::|..|........||.|..||  .|..:|||:.|:......:| |.|..|....:.|.:||
Mouse   287 TSTQIIMMTGFLVIFTLFFLYGLS--LIAVTFLMAVLLQKAVLTNLIVLFFTLFWGCVGFTVLH- 348

  Fly   200 KGCSEGLNVFLSLF----LLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVM- 259
            |.....|...||:|    ..||:..::     ::||...   |.:|..  |.|.   .|:::.:
Mouse   349 KELPPSLEWVLSIFSPFAFTSGMAKVI-----FQDYNLN---GVVFPD--PSGE---SYVMIAVF 400

  Fly   260 -ILA--SFLSLLLCLYLEKI-------RPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIY 314
             |||  |.|.|:|.||.:||       |..|.....|     |.|        :.:..|| ..:.
Mouse   401 FILAFDSLLYLVLALYFDKILLYGAEHRSAPLFFLNP-----TSC--------FRKTANR-NKVI 451

  Fly   315 SAAPDEERPDLQLIEP-DPVDKIAG---VQIRGLSKTF----GKMEVVKNVSFDMFEGQITVLMG 371
            ....|.|.|..:..|| ||  :..|   ::||.:.|.:    ||::.:|.:..|::|.|||.::|
Mouse   452 ERDLDPELPSDEYFEPVDP--EYQGKEAIRIRNIKKEYKGKSGKVKALKGLFLDIYESQITAILG 514

  Fly   372 HNGAGKTTLISMLAGFISPTSGTALINGFDI--RQERRQAQRCIGLCPQQNVLFKHLSSVSHIQL 434
            |:||||::|:::|:|...||:|:..:...::  .|:.::.::.||:|||.||.|..|:...::.|
Mouse   515 HSGAGKSSLLNILSGLYVPTAGSVTVYNKNLSDMQDLKEIRKAIGVCPQHNVQFDALTVKENLTL 579

  Fly   435 FSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTG 499
            |::::|:...:|:.|||..|.:|::|..:...|.:||.|.:|:|:...:..|..::|:.|||:.|
Mouse   580 FAKIKGILPQDVEQEVQQILSELDMQNIRDDLAEHLSEGQKRKLTFGIATVGDPQILLLDEPTVG 644

  Fly   500 LDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCL 564
            |||.:|:.:|..:.|.:....||.:|..:|:.::|.||.|:|::|.|:|.||..|||::......
Mouse   645 LDPFSRQRIWGFLKERRADHVILFSTQFMDEADILADRKVLIANGALKCTGSSVFLKRKWGLGYH 709

  Fly   565 ITCEARKRCDLEKLTSLISRHVGTIQPFS-IKGR---DVCYKLPLSKSKYFSSLFRDLESQMNIL 625
            ::....:.||.|:|||.|:.|:    |:: :|.:   .:.|.|||.::..|...|.||:.... .
Mouse   710 LSLFMDETCDSERLTSFINHHI----PYAKLKAKTKEKLVYILPLERTSEFPEFFSDLDKYSG-Q 769

  Fly   626 GVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDDDEE------NEVQDGNVRSCKKQ 684
            |:..:.:|..:|.::|::...|....:.....|...|.:..:|.|      ::||:  ..|....
Mouse   770 GLMSYEVSMSTLNDVFLNLEGEPSTKQDFEKRETATDSESLNDMEVAYPSLSQVQE--TVSTMSL 832

  Fly   685 WR----AMMTKKVMALYDNKVYFLLLL------LTPIVY-YITTLMMATKPHHSGRPTFNISDYG 738
            ||    |:...:::.|...:..||::|      |.|:|. |:...::..|         |..::.
Mouse   833 WRMQVCAIARLRILKLKRERKAFLIILLLLGIALLPLVIEYVANALLEVK---------NNWEFK 888

  Fly   739 VDKF------------TILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDYVDDKWKSR 791
            .|.:            |.||.:    :.||....|.:.||   |.:.||:.      ||| :::|
Mouse   889 TDLYFLSPGQLPQGLRTSLLVI----NNTESNIEDFLQSL---KHQNIVLE------VDD-FENR 939

  Fly   792 EGRREINFVSMAIDTGDRTGLIGWVGPRHY----------VHAAPMILNLVYNALAQELIGPKIS 846
            .....:::....|.:|.:         :.|          :|..|:::|::.|.:...|...:.
Mouse   940 NATNSLSYNGAIIVSGRQ---------KDYRFSAVCNTKRLHCFPILMNVISNGILHMLNHTQY- 994

  Fly   847 IEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSI-AMIIFSSAVIQERVSHMKMLQE-------- 902
                     :|.|||..      .|..|:.:..| ...:|...||.....|:.|...
Mouse   995 ---------IRIKEDIF------SPFIVLVWTGIQETCLFILCVICSLSPHIAMSSVSDYKKKAD 1044

  Fly   903 ----VSGLEMITYWLSHLAFDMVVFFILVLALLLPLYGYAPWYLLLCVLFFTGLAGLIFIYFLIS 963
                :|||....||......|                          :..|:|:  |:..||
Mouse  1045 SQLWISGLYPSAYWCGQAVVD--------------------------ISLFSGM--LLTSYF--- 1078

  Fly   964 MLSATFLAVSMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLC 1028
             .|.|...:::.:.|.|:.|:|::.||..|.:..:.||..:|.......:....|  || .:.:.
Mouse  1079 -TSYTSKLLNIDMTSEIVFSVIVLALGCAASLVFLTYVISFVFGKRKKNSTLWSI--CF-LLVIA 1139

  Fly  1029 GSYISEAQNPLSENLT-SDEM----YCINP-LAFLEPRCV--------CVNPMTWPDMLVML--- 1076
            .::...|..|.:|.|. |..|    :.:|. |..||.|..        ..:.::..|:|:.|
Mouse  1140 ITFEKVANGPFNEALVISATMLVPSFALNGLLVVLEMRAYQYYIEFEEIKHGLSAVDLLLCLIPY 1204

  Fly  1077 -GTAIILFLL-IMFFEYGSCVWYR--CKGCCPYSSKGS-------IEDPKVSREAEKIRAMDA-- 1128
             .|.:.:|:| .:..:||..|..|  .....|.|.|..       .||..|  :||::|..||
Mouse  1205 IHTLLFIFVLRCLELKYGKNVVRRDPIFRIAPQSLKAQPNPEEPIDEDENV--QAERLRTSDALS 1267

  Fly  1129 -DQIGTRALVVNGV-------SKKYGCDQ----LAVNNISFALKPSHCVGLLGPNGAGKTTTFKM 1181
             ..:..:.:::...       .||:.|.:    :||.|:||.:.....:|||||:||||:::.:|
Mouse  1268 TPNLDEKPVIIASCLHKEYAGQKKHCCSRRTRNMAVRNVSFCVNKGEILGLLGPDGAGKSSSIRM 1332

  Fly  1182 IVGEHSIDKGNIYISGYSMRM-KRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLN 1245
            |.|......|.:.:...|..: .:..:..|.|||||.:..:..||.::.|:::..:.|...:|..
Mouse  1333 IAGITKPTAGQVELKRLSSAVGHQGDSRAEFGYCPQENGLWPNLTVKEHLELYAAVKGLRKEDAV 1397

  Fly  1246 KRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVACGANS-LICLDEPSAGVDPASRRHVWTII 1309
            ....:|.:.......|:.::.....|..||:...::...|| ::.|||||.|:|.:.:..||..|
Mouse  1398 VAISRLVNALKLHDQLNVQVQNLVAGATRKLCFVLSILGNSPVLILDEPSTGLDVSGKHQVWQAI 1462

  Fly  1310 NEVAQQG-KAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKL-VVNVQPD 1372
            ..|.:.. |.|||::|::.|..|||.::.|:|.|.:..:|.:||:|.|..:...|:| |.:|..:
Mouse  1463 QAVVKDNEKGVLLSTHDLAEAEALCDRAAIMVSGRLRCIGPIQHLKRKFGQDYVLELRVKDVSQE 1527

  Fly  1373 NMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQ--ISKDTSWSEIFEYVEGNRSSWHLEDYSL 1435
            .:|      ..:|...:|.|..:::. || .||::  ::.....|:.|..:|..:..:.||||||
Mouse  1528 PLV------HREILKLFPQAARQDRC-FS-LLTYKLPVTDVHPLSQAFHKLEAVKHGFDLEDYSL 1584

  Fly  1436 SQPSLEDAFEEIAEER 1451
            ||.:|:....|:::|:
Mouse  1585 SQCTLDRVILELSKEQ 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	101/319 (32%)
		ABC_subfamily_A	339..556	CDD:213230	76/222 (34%)
		ABC2_membrane_3	<821..1018	CDD:289468	41/219 (19%)
		CcmA	1135..1450	CDD:224054	93/331 (28%)
		ABC_subfamily_A	1136..1354	CDD:213230	66/231 (29%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	397/1574 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6373
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.670