DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca12

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_780419.2	Gene:	Abca12 / 74591	MGIID:	2676312	Length:	2595	Species:	Mus musculus

Alignment Length:	1668	Identity:	441/1668 - (26%)
Similarity:	741/1668 - (44%)	Gaps:	335/1668 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LYKTGFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVII 74
            :|...|:.:|.::.:..|:.:... |..:..::   ::.:|. |.|..||..|.....:.|::::
Mouse  1013 IYGRAFIYLQDSIERAIIELQTGR-NSQEVAVQ---VQAVPY-PCFMKDNFLTSVSYSLPIVLMV 1072

  Fly    75 IFFV-VVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQT--FIIFLIGSSIITLFWKLVLP 136
            .:.| :.:..|.:|.||:|:|...:.:|||.||..:.||.|::  |::..|...|:.|.:..:||
Mouse  1073 AWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESIGFLLVTIAILIVILKFGNILP 1137

  Fly   137 --NSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHS 199
              |..|.|:.|:.:|.::          |..|:|:|...:.|...:|:..|..:..:.||::|.:
Mouse  1138 KTNGFILFLYFSDYSFSV----------IAMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVT 1192

  Fly   200 --KGCSEGLNVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILA 262
              ...|..:.||:||...:........|..:|:.|.||||.|::::.....|.|.|::..:::..
Mouse  1193 VEDELSYVIKVFMSLLSPTAFSYASQYIARYEEQGVGLQWENMYKSPVQDDTTSFGWLCCLILAD 1257

  Fly   263 SFLSLLLCLYLEKIRPGPYGVPQPWHFPCT--------RCCSTESLLPYSRLFNRIFGIYSAAPD 319
            ||:...:..|:..:.||.||:..||:||..        .|...:.......:|..|. :.:..|.
Mouse  1258 SFIYFFIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKHEKSNGLMFTNIM-MQNTNPS 1321

  Fly   320 EER--PDLQL---IEPDPVDKIAGVQIRGLSKTFGKMEVVKNVSFDMFEGQITVLMGHNGAGKTT 379
            ..:  ||...   |||:|.|...||.:.|::|.:|....|:|::.:.:||.||.|:|.|||||||
Mouse  1322 ASKTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVENLNLNFYEGHITSLLGPNGAGKTT 1386

  Fly   380 LISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLR--GLR 442
            .||||.|....|:||..:.|.||:.:....::.:|:|.|.:|||.:|::..|:.|:..::  ...
Mouse  1387 TISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWT 1451

  Fly   443 GAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRE 507
            ..::..||:..||...|...:......||||.:|:||::.:|.||.:|:|.||||||:||.:||.
Mouse  1452 KTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRS 1516

  Fly   508 LWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLITCEARKR 572
            :|.:|.:.|...||:|:||.||:.|||.||:..:..|.|||.||..:||:.......:|...:|.
Mouse  1517 IWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKS 1581

  Fly   573 --------CDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKY---FSSLFRDLESQMNILG 626
                    ||...:|::|..|:.........|.::.|.||...:|.   :.||.|.|:..|..|.
Mouse  1582 PNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLN 1646

  Fly   627 VRGFSLSSVSLEEIFM----------SFGAEDLNSRQSG-----GAEKRDD--------DDRDDD 668
            :..:.:|..::||:|:          :...|.|..|:.|     |....||        .||||.
Mouse  1647 IGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDK 1711

  Fly   669 EENEVQDGNVRSCKKQWRAMMTKKVMALYDNKVY--------FLLLLLTPIVYYITTLMMAT--- 722
            .       ..||.|.:...::.||:||:...:.:        .:..::.|||:..|.:.:.|
Mouse  1712 V-------LTRSEKLEGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVATAMGLGTLRD 1769

  Fly   723 ---------------------------KPHHSGRPT----------------------------F 732
                                       .|..||..:                            :
Mouse  1770 SSNSYPEIMISPSIYGTSEQTAFYANFDPSTSGLVSALWNFPGIDNVCLNTSDLQCLKKDDLGKW 1834

  Fly   733 NISDYGVDKFTI------LLSVPVSKSYTEERR--ADSIASLIKGKLK---LIVVSEQIKDYVDD 786
            |.|...:|.|.:      :...|....:...||  :..:...:.||..   ||..:.........
Mouse  1835 NTSGEAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGKHMENYLITTANHFVQKRYG 1899

  Fly   787 KWK-SREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQ----ELIGPKIS 846
            .|. ..:...::.|...|: ..:||....|..|..| |:.|..||.:.|.|.:    |....:..
Mouse  1900 GWSFGMKLTNDLRFDVTAV-PDNRTLAKVWYDPEGY-HSLPAYLNSLNNFLLRVNMSEYDAARHG 1962

  Fly   847 IEVTSVPFT-LRKKEDFLISNNGDIPI---YVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLE 907
            |.:.|.|:. ::.:|...||:..||.:   .::|| |:....|.:.:::|..:..|.||.:||:.
Mouse  1963 IIMYSHPYPGVQDQEQATISSLIDILVALSILMGY-SVTTASFVTYIVREHQTKAKQLQHISGIG 2026

  Fly   908 MITYWLSHLAFDMVVFFILV-----------------------LALLLPLYGYA--PWYLLLCVL 947
            :..||:::..:|||.:.:.|                       ::|||.|:|||  .|..||..|
Mouse  2027 VTCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGL 2091

  Fly   948 FF-TGLAGLIFI----YFLISMLSATFLAVSMILLSVIIG-----------SLILMILGALALIF 996
            |. ||:|.:.::    :|.|:         |::.|||:..           .||...|..:.|||
Mouse  2092 FHETGMAFITYVCVNLFFGIN---------SIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIF 2147

  Fly   997 KMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPL-----------SENLTSDEMYC 1050
            .                     |.||.|..:   .:|:.|..|           ||....|::..
Mouse  2148 P---------------------QFCFGYGLI---ELSQQQAVLDFLKAYGVEYPSETFEMDKLGA 2188

  Fly  1051 INPLAFLEPRCVCVNPMTWPDMLVMLGTAIILFLLI----------MFFEYGSCVWYRCKGCCPY 1105
            :    |:              .||..||...|..|:          :||.             .:
Mouse  2189 M----FV--------------ALVSQGTMFFLLRLLINEWLIKKLRLFFR-------------KF 2222

  Fly  1106 SSKGSIE--DPKVSREAEKIRA------MDADQIGTRALVVNGVSKKYGCDQLAVNNISFALKPS 1162
            :|...:|  |......||:.|.      .|..|:.........:.||.    :||||||..:...
Mouse  2223 TSSPIMETVDEDEDVRAERFRVESGAAEFDLVQLHRLTKTYQLIHKKI----IAVNNISLGIPAG 2283

  Fly  1163 HCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKA---------MKELGYCPQSD 1218
            .|.||||.|||||||.|||:.|:.....|||.|        |||:         ...:|||||.|
Mouse  2284 ECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILI--------RNKSGSLGHVDSHSSLVGYCPQED 2340

  Fly  1219 SFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-C 1282
            :..:.:|..:.|..:..:.|.|.||:.....||..:.....:.|:..:..|.|||||::.|:| .
Mouse  2341 ALDDLVTVEEHLYFYARVHGIPEKDIKDTVHKLLRRLHLMAYKDRSTSMCSYGTKRKLSTALALI 2405

  Fly  1283 GANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAM 1347
            |..|::.|||||:|:||.|:||:|.||:|..|...:|:||||:|:|..|||::..|:|:|....:
Mouse  2406 GKPSILLLDEPSSGMDPKSKRHLWRIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGRFQCI 2470

  Fly  1348 GSVQHVKNKIAKGMTLKLVVNVQPDNMVAM--LTKIEDDIYMTYPNAELKEKYEFSGRLTFQISK 1410
            ||:||:|::..:|.|:|:.:.   :|.|:|  |||.   :.:.:|...||:::  ...|.:.:..
Mouse  2471 GSLQHIKSRFGRGFTVKVHLK---NNKVSMETLTKF---MQLHFPKTYLKDQH--LSMLEYHVPV 2527

  Fly  1411 DTSW-SEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERR 1452
            .... :.||:.:|.|:::.::.::.:||.:||:.|...|::::
Mouse  2528 TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	112/329 (34%)
		ABC_subfamily_A	339..556	CDD:213230	87/218 (40%)
		ABC2_membrane_3	<821..1018	CDD:289468	59/245 (24%)
		CcmA	1135..1450	CDD:224054	113/327 (35%)
		ABC_subfamily_A	1136..1354	CDD:213230	89/227 (39%)
Abca12	NP_780419.2	ABC2_membrane_3	<1006..1267	CDD:289468	66/268 (25%)
		NosY	<1108..1269	CDD:224196	43/170 (25%)
		ZnuC	1346..1570	CDD:224046	89/223 (40%)
		ABC_subfamily_A	1350..1565	CDD:213230	86/214 (40%)
		ABC2_membrane_3	<1913..2174	CDD:289468	72/296 (24%)
		CcmA	2253..2567	CDD:224054	113/333 (34%)
		ABC_subfamily_A	2254..2477	CDD:213230	90/234 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810