DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and abca3b

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	1593	Identity:	474/1593 - (29%)
Similarity:	769/1593 - (48%)	Gaps:	233/1593 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GSYPLYKTGFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDL----PSPPIFKSDNSSTLQDV 66
            |:...|:.|||.||.|:.:..:    ..:|::.....|...:.|    |.|..........:|:.
Zfish   199 GTPGYYREGFLQVQYAVDRAIM----MAYNRSAAMALFDQTQVLLSRFPYPAFIYDVFILAIQNQ 259

  Fly    67 GIMIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIIT-LF 130
            ..:::|:...:..:::.:::|:|||.:||..:.:||:.:.|.|.||::..|:...|....:| ||
Zfish   260 LPLLLVLSFTYTALNIVRAVVQEKERKLKEYMRMMGLSNWLHWSAWFLMFFLFLSISIFFVTVLF 324

  Fly   131 WKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFL 195
            ...|.||..:  :.::..::....|||.:..||.|||::|...|.....:.........:|||::
Zfish   325 CVKVSPNGAV--LTYSDPTLVFVFLLVFAISTINFSFMISVFFSRANVAAAAGGFIYFLSYLPYV 387

  Fly   196 IL--------HSKGCSEGL--NVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTL 250
            .|        |::..|..|  ||.:::    |.|:    |.|:|..|.|:||.||||........
Zfish   388 FLWPRYDLLSHAQKVSACLISNVAMAM----GAQL----IGMFEGKGTGIQWHNLFEAVTVDDDF 444

  Fly   251 SVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHF---PCTRCCSTESLLPYSRLFNRIFG 312
            |:..::.:::|.:.|..|:..|:|.:.||.|||||||:|   |...|.|..            ..
Zfish   445 SLAQVIGLLLLDALLYGLVAWYVEAVFPGEYGVPQPWYFFILPSYWCSSPR------------VA 497

  Fly   313 IYSAAPDEERPDL----QLIEPDPVDKIAGVQIRGLSKTF----GKMEVVKNVSFDMFEGQITVL 369
            ......|||..:.    :.:|.:|...:|||:|:.|:|.|    ...|.|::::.:|||||||||
Zfish   498 FLKEKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRLAKVFKVGNKSKEAVRDLTLNMFEGQITVL 562

  Fly   370 MGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQL 434
            :|||||||||.:|||.|...|:||.|.|||:||.|:....:|.:|||||.:|||.:|:...|:..
Zfish   563 LGHNGAGKTTTLSMLTGLFPPSSGRAYINGYDICQDMALIRRSLGLCPQHDVLFDNLTVREHLLF 627

  Fly   435 FSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTG 499
            :::|:|....::..||...::.|||::|:....:.||||.:|:||:..:|.|..||::.|||::|
Zfish   628 YTQLKGYPREKIPGEVDRIIRILNLEDKRNAKCKTLSGGMKRKLSIGIALIGDSKVVMLDEPTSG 692

  Fly   500 LDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCL 564
            :||||||..|.|:...|.|.|||||||.:|:.::||||:.|::.|:|:|.||..|||.:..|...
Zfish   693 MDPSARRATWDLLQGEKRGRTILLTTHFMDEADLLGDRIAIMASGELQCCGSPLFLKNKYGAGYH 757

  Fly   565 ITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMNILGVRG 629
            :.......|::.::|.|:..:|......|..|.::.|.||...:..|..||.:||...:.||:..
Zfish   758 MVIVKDAFCNVSEITRLVHMYVPDATLESSAGAELSYILPKESTSRFELLFAELEMNRDELGIAS 822

  Fly   630 FSLSSVSLEEIFMSFG-----AEDLNSRQSGGA----EKRDDDDRDDDEEN-----EV------- 673
            :..|..::||:|:..|     :.|:.:.|....    |:|..|...||..:     :|
Zfish   823 YGASVTTMEEVFLRVGKLVDSSLDIQAIQLPALQYQHERRSHDWTMDDSSSISGMTDVTDFTDSC 887

  Fly   674 ----QDGN-------VRSCKKQWRAMMTKKVMALYDNKVYFLLLLLTPIVYYITTLMMA---TKP 724
                :||:       .|...:|:.||..|:.:..:.|....:...|.|:::.:..|::|   ...
Zfish   888 TMISEDGSNIKLNTGARLYMQQFYAMFLKRALYSWRNWKVMVAQFLVPLIFTVLALVVARSLPSS 952

  Fly   725 HHSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASLI------KGKLKLIVVSEQIKDY 783
            |.|.:....:..||      ...|||:    .|..|..:|||:      :...:..:.:..|.|:
Zfish   953 HSSPQLRLALKQYG------QTHVPVA----VEANAGPLASLLAEIYTTQLPSQNAIAAPNITDF 1007

  Fly   784 VDDKW--KSREGR--REINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELIGPK 844
            .:...  ..|||.  .|...|..|..:.|   :||:...:.| |.....|.||.|||.:.|.||.
Zfish  1008 SEYVLYNAQREGGAFNEHCVVGAAFRSSD---VIGYFNNQGY-HTPATALMLVDNALFKLLAGPN 1068

  Fly   845 ISIEVTSVPFTLRKKE-----------DFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHMK 898
            .||:..:.|......|           .|.|:.|     .:.|..|:|. .|:..::.||....|
Zfish  1069 ASIQTGNDPMPRNVSETAQSQLSESQTGFAIAIN-----LMYGMASLAS-TFALLLVSERSVKSK 1127

  Fly   899 MLQEVSGLEMITYWLSHLAFDMVVFFILVLAL-----------------------LLPLYGYA-- 938
            .:|:|||:.:..:|.|.|.:|::.|.:..|.:                       ||.|||:|
Zfish  1128 HVQQVSGVYLTNFWFSALLWDLINFLLPCLLMLVVFRVFSVKAFVAQNHLVDVLFLLLLYGWAVI 1192

  Fly   939 PWYLLLCVLFFTGLAGL--IFIYFLISMLSATFLAVSMILLSVIIGSLILMILGALALIFK---- 997
            |...|:..||.|.....  :.|:.:||. :||||||:::.:..:....:..:|..:.|||.
Zfish  1193 PLMYLMSFLFSTAATAYTRLTIFNIISG-TATFLAVTIMTIPELNLLHLSHLLDKVFLIFPNYCL 1256

  Fly   998 -MVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSE------NLTSDEMYCINPLA 1055
             |.:...|        ..|..|..|             ..:||::      |:|    |.:|..:
Zfish  1257 GMSFTEFY--------QNYEMITFC-------------TSSPLAKYICKYYNIT----YQMNYFS 1296

  Fly  1056 FLEPRCVCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCVWYRC----KGCCPYSSKGSI----- 1111
            ..||..        ...||.|....::|::::|.     :..||    ...|....|..:
Zfish  1297 MEEPGV--------GRFLVALSLQGVVFIILLFL-----IELRCIRLLLNLCRRRKKALLLAEEA 1348

  Fly  1112 ---EDPKVSREAEKI---RAMDADQIGTRALVVNGVSKKY--GCDQLAVNNISFALKPSHCVGLL 1168
               ||..|:.|.:::   :.:....:|: .|||..:||.|  |...|||:.:|.|:....|.|||
Zfish  1349 LQPEDRDVAEERKRVLECQPVVESMVGS-PLVVQELSKMYSGGQSLLAVDRLSLAVGKGECFGLL 1412

  Fly  1169 GPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVF 1233
            |.|||||||||||:.|:.||..|:.:|.|||:.....|..:.:|||||.|:..:.:|||:.|.::
Zfish  1413 GFNGAGKTTTFKMLTGDESITSGDAFIDGYSILTDVKKVQQRIGYCPQFDAVLDHMTGRETLSMY 1477

  Fly  1234 LLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGV 1297
            ..:.|.|.|.:....|.:........|.||.:..||||.|||::|.:| .|...:|.|||||.|:
Zfish  1478 ARLRGIPEKYVTACVENVLRSLLLEPHADKLVRSYSGGNKRKLSAGMALIGGPPVIFLDEPSTGM 1542

  Fly  1298 DPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMT 1362
            ||.:||.:|..|....:.|||:::|||:|:|..|||::..::|:|....:||.||:|:|...|.|
Zfish  1543 DPVARRLLWDAITRTRESGKAIIITSHSMEECEALCTRLAVMVNGQFKCLGSPQHLKSKFGSGYT 1607

  Fly  1363 LKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQIS-KDTSWSEIFEYVEGNRS 1426
            |...|.|:.:...:.|...:|.|..|:|.:.||::::  |.:.:.:: |..:|:::|..:|..:.
Zfish  1608 LLAKVRVETELEESDLQLFKDFIESTFPGSLLKDEHQ--GMVHYHLTDKTLTWAQVFGVLETAKE 1670

  Fly  1427 SWHLEDYSLSQPSLEDA------FEEIAEERRK 1453
            .:.:|||.:||.|||..      |:..||..||
Zfish  1671 KYSIEDYCVSQISLEQVFLSFAQFQHCAEACRK 1703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	127/310 (41%)
		ABC_subfamily_A	339..556	CDD:213230	102/220 (46%)
		ABC2_membrane_3	<821..1018	CDD:289468	62/239 (26%)
		CcmA	1135..1450	CDD:224054	123/324 (38%)
		ABC_subfamily_A	1136..1354	CDD:213230	94/220 (43%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	469/1583 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3783
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.930