Protein Alignment CG42816 and abca1a

DIOPT Version :9

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_001296394.1
• Gene: abca1a / 558924
• ZFINID: ZDB-GENE-031006-12
• Length: 2268
• Species: Danio rerio
• Alignment Length: 1707
• Identity: 454/1707 - (26%)
• Similarity: 773/1707 - (45%)
• Gaps: 399/1707 - (23%)

  Fly    46 IKDLPSP----PIFKSDNSSTLQDVGIMIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSC 106
            |:.:|.|    .||....|.::.    :.:.:...:.|..:.|.:|.|||.:||.|:.:||:.:.
Zfish   623 IQQMPYPCYVDDIFLRVMSRSMP----LFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGLDNG 683

  Fly   107 LQWVAWYIQTFIIFLIGSSIITLFWKL--VLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLM 169
            :.|::|:|.:.|..||.::::.|..|:  :||.|:...:   :..::.|.::.:..|     ||:
Zfish   684 ILWLSWFISSLIPLLISAALLVLILKMGNLLPYSDPGVI---YLFLSSFAVVTIMQC-----FLI 740

  Fly   170 SSLISTTYRISLVTFLALIATYLPFLILHSKGCSEGLNV--FLSLFLLSGLQVLVVG-----ICM 227
            |:|.|.....:....:.....|||:::     |....|.  |.:..::|.|..:..|     ..:
Zfish   741 STLFSRANLAAACGGIIYFTLYLPYVL-----CVAWQNYVGFGAKIVVSLLSPVAFGFGCEYFAL 800

  Fly   228 WEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCT 292
            :|:.|.|:||.||..:.....:.::...:.:|:..|.|..::..|:|.:.||.||:|:||:||.|
Zfish   801 FEEQGVGIQWSNLLSSPMQEDSYNLTTSICLMLFDSVLYAVMTWYIEAVFPGQYGIPRPWYFPFT 865

  Fly   293 R---C---CSTESLLPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQIRGLSKTFGKM 351
            :   |   |...:.:|.:|              :|..:...||.:|.....||.|..|.|.:...
Zfish   866 KSYWCGEKCGWTTSVPSNR--------------KENAEAVCIEEEPAHIDPGVYIENLMKIYSNG 916

  Fly   352 EV-VKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGL 415
            :| |..::...:|||||..:|||||||||.:|:|.|...||||||.|.|.|||.:....::.:|:
Zfish   917 KVAVDGLTLGFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIQGKDIRTDLNAIRQNLGV 981

  Fly   416 CPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSV 480
            |||.||||..|:...||..::||:||...:||||::..:..|.|..|:...:..||||.||:|||
Zfish   982 CPQHNVLFSMLTVEEHIWFYARLKGLSAEKVKSEMEQIVMDLGLPHKRTSRSNQLSGGMQRKLSV 1046

  Fly   481 ACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQ 545
            |.:..||.||:|.|||:.|:||.|||.:|.|:|:.::|.||:|:||.:|:.::||||:.|||.|:
Zfish  1047 ALAFVGGSKVVILDEPTAGVDPYARRGIWDLLLKYRQGRTIILSTHHMDEADILGDRIAIISHGK 1111

  Fly   546 LRCIGSLPFLKKQVDASCLIT------------CEARK--------------------------- 571
            |.|:||..|||.|:.....:|            |....
Zfish  1112 LCCVGSSLFLKTQLGTGYYLTLVKKDFDLSASSCRTSSSTVSYSKGSLKKDDSVSESSSDAGLGS 1176

  Fly   572 -------RCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSK--YFSSLFRDLESQMNILGV 627
                   ..|:..::::|.:||.|.:.....|.::.|.||...:|  .|..||.:::.::..|.:
Zfish  1177 DHESETTTIDISLISNVIFKHVPTARLVEDLGHEITYVLPYESAKDGAFVELFHEIDDRLTDLSI 1241

  Fly   628 RGFSLSSVSLEEIFMSFGAEDL---------------NSRQSGGAEK-------RDDDDRDDDE- 669
            ..:.:|..:|||||:.. |||.               |.|.:.|..:       .||.|.:|.|
Zfish  1242 SSYGISDTTLEEIFLKV-AEDCGVDAETSDGTLPARRNRRHAFGDHQSCLKPFTEDDFDFNDSEG 1305

  Fly   670 -----ENEVQDG-------NVRSC---KKQWRAMMTKKVMALYDNKVYFLLLLLTPIVYYITTLM 719
                 |.:..||       .|:..   ::|:.|::.|:::....::..|...::.|.|:....|:
Zfish  1306 DPESRETDWLDGADGKGSYQVKGWSLKRQQFVALLWKRLLYARRSRKGFFAQIVLPAVFVCIALV 1370

  Fly   720 -------------MATKPH-HSGRPTFNISDYGVDKFT--ILLSVPVSKSYTEE----------- 757
                         :|.:|. :..:.||..:|...|:.|  :|.::..|.:||::
Zfish  1371 FSLIVPPFGKYPSLALEPSMYEEQFTFISNDAPEDRHTNRLLDALKDSPAYTDQCTDGKNTASRS 1435

  Fly   758 -----------RRADSIASLI------------------KGKLKLI---------VVSEQIKDYV 784
                       ...:||.::.                  :|:.|::         :...|||...
Zfish  1436 CPIKDGEWLVPEVTESIEAIFLNGNWSMENPSPLCECSCEGRKKMLPECPPGAGGLPPPQIKVTH 1500

  Fly   785 DDKWKSREGRREINFV--------------------------------SMAIDTGDR-TGLIGWV 816
            |:..::..||...:::                                :.|:..||. |..|..:
Zfish  1501 DETLQNLSGRNISDYLVKTYAQIIGKSLKNKLWVNEFRYGGFSLGARNTQALPPGDELTDAISHI 1565

  Fly   817 GPRHYV-----------------------------------HAAPMILNLVYNALAQELIGP--- 843
            ..|..:                                   |:....||::.||:.:..:.|
Zfish  1566 RSRFSLESGTAADRFLGSLSTFIRGLDTNNNVKIWFNNKGWHSIGSFLNVMNNAVLRANLPPGLD 1630

  Fly   844 --KISIEVTSVPFTLRKKE-----------DFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERVS 895
              |..|...:.|..|.|::           |.|:|   ...|:.:.:|..:.::|   :|||||:
Zfish  1631 RSKFGINAFNHPLNLTKEQLSHVALMTTSVDVLVS---ICVIFAMSFVPASFVVF---LIQERVN 1689

  Fly   896 HMKMLQEVSGLEMITYWLSHLAFDM----------VVFFIL-------------VLALLLPLYGY 937
            ..|.:|.:||::...|||::..:||          ::.|:.             ||||||.|||:
Zfish  1690 KAKHMQFISGVQPFLYWLANFVWDMCNYIVPATLVIIIFVCFQQEAYVSSTNLPVLALLLLLYGW 1754

  Fly   938 APWYLLLCVLFFTGLAGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMIL--------GALAL 994
            :...|:....||..:....::           :..|:.:|..|.||:...:|        |.:..
Zfish  1755 SITPLMYPASFFFKIPSTAYV-----------VLTSVNILIGINGSVSTFVLELFGSNEIGGIND 1808

  Fly   995 IFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEP 1059
            |.|.|:          ||..:.|:.:....| :....:::|.....||...      :|||:
Zfish  1809 ILKNVF----------LIFPHFCLGRGLIDM-VKNQAMADALERFGENRFR------SPLAW--- 1853

  Fly  1060 RCVCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCVWYRCKGCCPYSSK----GSIEDPKVSREA 1120
                  .|...::..|....:|.|.:.:..:|..|:..|     ..|:|    |. ||..|:||.
Zfish  1854 ------DMVGKNLFAMAIEGVIFFSITVLIQYRFCIKAR-----SLSTKLKPIGE-EDEDVARER 1906

  Fly  1121 EKIRAMDADQIG----TRALVVNGVSKKYGCDQL-AVNNISFALKPSHCVGLLGPNGAGKTTTFK 1180
            ::|       :|    |..|.:..::|.|...|. ||:.:...:.|..|.||||.||||||:|||
Zfish  1907 QRI-------LGGGGQTDILELRQLTKVYKRKQKPAVDRLCVGIPPGECFGLLGVNGAGKTSTFK 1964

  Fly  1181 MIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLN 1245
            |:.|:..:..|..|::|.|:..:.::..:.:|||||.|:..:.||||:.|:.:.::.|.|.|::
Zfish  1965 MLTGDSVVTSGEAYLAGNSVLTEIDEVHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPEKEV- 2028

  Fly  1246 KRCEKLAD----QFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHV 1305
              | |:||    :.|..|::||....||||..||::.|:| .|...::.||||:.|:||.:||.:
Zfish  2029 --C-KVADWGIRKLGLMKYVDKAAGSYSGGNMRKLSTAMALIGGPPVVFLDEPTTGMDPKARRAL 2090

  Fly  1306 WTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVVNVQ 1370
            |..|..:.::|::|:||||:|:|..|||::..|:|:|....:|||||:|||...|.|:.|.|...
Zfish  2091 WNCILSIIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNKFGDGYTIILRVAGA 2155

  Fly  1371 PDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKD-TSWSEIFEYVEGNRSSWHLEDYS 1434
            ...:..::..||.::    |.:.||||:.  ..|.:|:|.. ||.:.||..:..|:...|:||||
Zfish  2156 DPRLEPVMEFIEREL----PGSTLKEKHR--NMLQYQLSSSLTSLARIFNILSKNKEQLHIEDYS 2214

  Fly  1435 LSQPSLEDAFEEIAEER 1451
            :||.:|:..|...|:::
Zfish  2215 VSQTTLDQVFVNFAKDQ 2231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	129/355 (36%)
		ABC_subfamily_A	339..556	CDD:213230	103/217 (47%)
		ABC2_membrane_3	<821..1018	CDD:289468	56/278 (20%)
		CcmA	1135..1450	CDD:224054	120/321 (37%)
		ABC_subfamily_A	1136..1354	CDD:213230	88/223 (39%)
abca1a	NP_001296394.1	rim_protein	1..2233	CDD:130324	454/1707 (27%)
		ABC_subfamily_A	904..1122	CDD:213230	103/217 (47%)
		ABC_subfamily_A	1919..2139	CDD:213230	88/223 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3783
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830