DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and abch1

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_021328839.1	Gene:	abch1 / 558667	ZFINID:	ZDB-GENE-050517-42	Length:	713	Species:	Danio rerio

Alignment Length:	828	Identity:	167/828 - (20%)
Similarity:	305/828 - (36%)	Gaps:	238/828 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 AGVQIRGLSKTFGKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSG--TAL--- 396
            |.:....:.:::||::|:.|::..:.:|||..|:|.:|.|||||:..:.|.:..:.|  |.|
Zfish    37 AAIHCHDVCRSYGKLKVLNNLNLTLPQGQIYGLLGPSGCGKTTLLKCIVGTLKISRGHITVLGKP 101

  Fly   397 --INGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNL 459
              ..|.::      ..:.:|..||...|:...:..:.:..|.|:.||...|.::.:...:..|:|
Zfish   102 PAFPGHEV------PGKMVGYMPQDIALYNEFTISNTLWFFGRIHGLSSKETEARMSFLIDFLDL 160

  Fly   460 QEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEG--CTIL 522
            .:|..| .:|||||.:||:|:..:|....|:||.|||:.|:||..|.::|:.::|...|  .:|:
Zfish   161 PQKHSL-VKNLSGGQRRRVSLGAALLQNPKLLILDEPTVGVDPVLRAKIWQHLVEIVRGGQVSII 224

  Fly   523 LTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVG 587
            :|||.:::.. ..:.|.::.:|:|...|....:.||.:|:.|.|.
Zfish   225 ITTHYIEEAR-QANTVGLMRNGRLLAEGPPDAVMKQHNAATLETA-------------------- 268

  Fly   588 TIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSR 652
                                   |..|..|                            ::....:
Zfish   269 -----------------------FLQLCED----------------------------SDQSGPK 282

  Fly   653 QSGGAEKRDDDDRDDDEENEVQDGNVR--------SCKKQWR--------------AMMTKKV-- 693
            ||......|.....|...:|:::..:|        .||..|:              |:|.|.:
Zfish   283 QSPQGRLLDSSPSPDSMRDEIREPILRKSTSEEMPKCKADWKVRARHIIPKWSNIAALMIKTMVR 347

  Fly   694 MALYDNKVYFLLLLLTPIVYYITTLM----------MATKPHHSGRPTFNISDYGVDKFTILLSV 748
            |......:.|..||  |::......:          :|...:.|....|:.|.......|.:..|
Zfish   348 MRRLPGSLCFQFLL--PVIQICLMCLCIGGDPKNIDVAVVNNESSPSAFSRSLLSFLDNTSINQV 410

  Fly   749 PVSKSYTEERRADSIASLIKGKL-KLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGL 812
            .:|.|       |:...:..|:. .:|...|....|:..:.......||:      ::.|.
Zfish   411 SLSHS-------DAFDGIRNGEYWGVIEFGENFTSYLTKRMLQPRVSREV------VEGGS---- 458

  Fly   813 IGWVGPRHYVHA---------APMI---LNLVYNALAQELIGPKISIEVTSVPFTLRKKEDFLIS 865
                     |||         |.|:   |:..:.|..::.:| .:|..| :||  ::.:|....|
Zfish   459 ---------VHAWLDLTNRQIALMLQKKLHQAFEAFMEKRLG-SMSYMV-AVP--IKFEEPIYGS 510

  Fly   866 NNGDIPIYVIG--------YVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVV 922
            .|.|...:|..        |:::.:...|  .:.||...:.....|:|:..:...|:||...:.|
Zfish   511 KNTDFTTFVTPGAVLSITFYLAVGLTALS--FVLERKEGLLDRCWVAGVSSLETMLAHLFSQLFV 573

  Fly   923 FFILVLALLLPLYGYAPWYLLLCVLFFTGLAGLIFIYFLISMLSATFLAVSMILLSVIIG-SLIL 986
            ..:.::.||:                ||      .:.|.|....:..|.:|:|:|..:.| |..|
Zfish   574 ISVQIILLLI----------------FT------LLVFNIPNEGSLALVISLIVLQGVTGISFGL 616

  Fly   987 MILGAL--ALIFKMVYVAIYVANMHPLIAG----YNCIQKCFHYMSLC--GSYISEAQNPLSENL 1043
            :|..|:  ........:.::..|:  :::|    ..||.....|:||.  .:|.|||.
Zfish   617 VISSAIDDEQSANQAALGVFYPNL--ILSGVIWPVECIPYPLRYLSLVLPQTYASEAL------- 672

  Fly  1044 TSDEMYCINPLAFLEPRCVCVNPMTWPDMLVMLGTAIIL-----FLLI 1086
                            ||:.........|:|..|.|:.|     ||::
Zfish   673 ----------------RCIMYRGWGLSRMMVWRGFAVTLGWNTFFLML 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	72/314 (23%)
		ABC_subfamily_A	339..556	CDD:213230	63/225 (28%)
		ABC2_membrane_3	<821..1018	CDD:289468	44/223 (20%)
		CcmA	1135..1450	CDD:224054
		ABC_subfamily_A	1136..1354	CDD:213230
abch1	XP_021328839.1	CcmA	38..>261	CDD:224054	65/230 (28%)
abch1	XP_021328839.1	ABC2_membrane_3	352..705	CDD:315386	82/434 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900