DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca17

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001026792.2	Gene:	Abca17 / 381072	MGIID:	3625331	Length:	1733	Species:	Mus musculus

Alignment Length:	1595	Identity:	435/1595 - (27%)
Similarity:	759/1595 - (47%)	Gaps:	247/1595 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ADGSYPLY-KTGFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDL-------PSPPIFKSDNS 60
            |||..|.| |.||||:|.|:.:..::|...:       ......|||       |..|..:....
Mouse   198 ADGGNPGYNKEGFLAIQHAVDKAIMRHHAPK-------AALNMFKDLHVLVQRFPFGPHIQDPFL 255

  Fly    61 STLQDVGIMIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSS 125
            ..||:...:::::....|.:.:|.|::.|||.:.|..:::|||.|.|.||||:|..||...|..|
Mouse   256 VILQNEFPLLLMLSFICVELIITNSVLSEKERKQKEYMSMMGVESWLHWVAWFITFFISVSITVS 320

  Fly   126 IITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIAT 190
            ::|:.:...:  :.::....::.::....|:..:..||.|:|:||:.....:..:::.......|
Mouse   321 VMTVLFCTKI--NRVAVFRNSNPTLIFIFLMCFAIATIFFAFMMSTFFQRAHVGTVIGGTVFFFT 383

  Fly   191 YLPFLIL----HSKGCSEGL--NVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGT 249
            |||::.:    |.:..::.:  .:|.::.:.:|::.    |.::|..|.|:||.|: .:.|  |.
Mouse   384 YLPYMYITFSYHQRTYTQKILSCLFSNVAMATGVRF----ISLFEAEGTGIQWRNI-GSVW--GD 441

  Fly   250 LSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIY 314
            .|...:|.:::|.|||..|:...:|.:.|..:|:|:.|:                        |:
Mouse   442 FSFAQVLGMLLLDSFLYCLIAFLVESLFPRKFGIPKSWY------------------------IF 482

  Fly   315 SAAPDEERPDL------------QLIEPDPVDKIAGVQIRGLSKTF----GKMEVVKNVSFDMFE 363
            :..|..|.|.|            ..::.:|.:::..::|:.|.|.|    .|...::::|.::::
Mouse   483 AKKPVPEIPPLLNIGDPEKPSKGNFMQDEPTNQMNTIEIQHLYKVFYSGRSKRTAIRDLSMNLYK 547

  Fly   364 GQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSS 428
            ||:|||:|||||||||:.|:|.|.|:|:.|.|.|:|.:|.::..|.::.:|.|||.::||.:.:.
Mouse   548 GQVTVLLGHNGAGKTTVCSVLTGLITPSKGHAYIHGCEISKDMVQIRKSLGWCPQHDILFDNFTV 612

  Fly   429 VSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLIC 493
            ..|:..:.:|:||...:...:.|..|..|.|::|....::.||||.:|:||:..:|..|.||||.
Mouse   613 TDHLYFYGQLKGLSPQDCHEQTQEMLHLLGLKDKWNSRSKFLSGGMKRKLSIGIALIAGSKVLIL 677

  Fly   494 DEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQ 558
            |||::|||..:||.:|.|:.:.|...|:|||||.:|:.::||||:.|::.|:|:|.||..|||::
Mouse   678 DEPTSGLDSPSRRAIWDLLQQQKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSPSFLKQK 742

  Fly   559 VDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMN 623
            ..|...:|......||..||:.:|..|:......|..|.::...||......|.:||.|||.:..
Mouse   743 YGAGYYMTIIKTPLCDTSKLSEVIYHHIPNAVLESNIGEEMIVTLPKKTIHRFEALFNDLELRQT 807

  Fly   624 ILGVRGFSLSSVSLEEIFM----------SFGAEDLNSRQSGGAEKRDDDDR-----------DD 667
            .||:..|:.|..::||:|:          :...|..:|........|...||           ..
Mouse   808 ELGISTFATSVTTMEEVFIRVCKLADPSTNVLTEKRHSLHPLPRHHRVPVDRIKCLHSGTFPVST 872

  Fly   668 DEENEVQDGNVRSCKKQWRAMMTKKVMALYDNKVYFLLL---LLTPIVYYITTLMMATKPHHSGR 729
            ::...:..|....| :|:.||:.||:  .|..:.:.|:|   :|.|:...:.:|..
Mouse   873 EQPMRLNTGFCLLC-QQFYAMLLKKI--TYSRRNWMLVLSVQVLLPLAIIMLSLTF--------- 925

  Fly   730 PTFNISDYGVDKFTILLS--------VP---VSKSYTEERRADSIASLI--KGKLKLIVVSEQIK 781
              ||.....:|...:.|:        ||   ...|:.:.:.:|....::  .|::.| .:...::
Mouse   926 --FNFKLRKLDNVPLELTLQTYGQTIVPFFIAENSHLDPQLSDDFVKMLVAAGQVPL-RIQGSVE 987

  Fly   782 DYVDDKWK-SREGRREINFVSMAI-DTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELIG-- 842
            |::..|.| :.||..::..|:.:. |..:.|.:......:.| |:..:.|.||.|.|.:.|.|
Mouse   988 DFLLKKAKEAPEGFDKLYVVAASFEDVNNHTTVKALFNNQAY-HSPSLALTLVDNLLFKLLSGAN 1051

  Fly   843 ----------PKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHM 897
                      |:.:|||:........|..:|:.|.    ::.|.::|.:   ||...:.|:....
Mouse  1052 ASITTTNYPQPQTAIEVSESILYQGPKGHYLVVNF----LFGIAFLSSS---FSILTVGEKSVKS 1109

  Fly   898 KMLQEVSGLEMITYWLSHLAFDMVVFFI----LVL-------------------ALLLPLYGYAP 939
            |.||.|||:....:|||.|.:|::.|.:    |||                   .|::.|||:|.
Mouse  1110 KSLQFVSGVSTAVFWLSALLWDLISFLVPTLLLVLVFLWYKEEAFAHHESIPAVVLIMMLYGWAV 1174

  Fly   940 WYLLLCVLFFTGLAGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMI------LGALALIFKM 998
            ..|:..|.|.....|...:..::.:   |||::|.::|..:.....|..      |..:.||...
Mouse  1175 IPLVYTVSFSFNTPGSACVKLVVML---TFLSISPVVLVTVTSEKDLGYTELSDSLDHIFLILPG 1236

  Fly   999 VYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVC 1063
            ..:.:.::|::     ||     |.....|.          ::||:  ::.|.:   .||...|.
Mouse  1237 HCLGMALSNLY-----YN-----FELKKFCS----------AKNLS--DIDCND---VLEGYVVQ 1276

  Fly  1064 VNPMTWPDM--------LVMLGTAIILFLLI----MFFEYGSCVWYRCKGCCP--YSSKGSI--- 1111
            .|...|..:        |.:||...|..|.:    .|:...|    |..|..|  :..|..:
Mouse  1277 ENIYAWESLGIGKYLTALAVLGPVYITMLFLTEANAFYVLKS----RLSGFFPSFWKEKSGMIFD 1337

  Fly  1112 ----EDPKVSREAEKIRAMDADQIGTRALVVNGVSKKYGCDQ---LAVNNISFALKPSHCVGLLG 1169
                ||..|..|||.|:......:....|||..|||.|. |:   ||||.:||.:|...|.||||
Mouse  1338 VAEPEDEDVLEEAETIKRYLETLVKKNPLVVKEVSKVYK-DKVPLLAVNKVSFVVKEEECFGLLG 1401

  Fly  1170 PNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFL 1234
            .||||||:.|.|:..|..|..|:.::.|::::....|..:.:||||:.|:...|:|||::|.::.
Mouse  1402 LNGAGKTSIFNMLTSEQPITSGDAFVKGFNIKSDIAKVRQWIGYCPEFDALLNFMTGREMLVMYA 1466

  Fly  1235 LIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVD 1298
            .|.|.|...:....:.:.:........||.:..||||.||.::..:| .|..::|.|||||.|:|
Mouse  1467 RIRGIPECHIKACVDLILENLLMCVCADKLVKTYSGGNKRMLSTGIALVGEPAVILLDEPSTGMD 1531

  Fly  1299 PASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTL 1363
            |.:||.:|..:..|.:.||.:::|||:|:|..|||::..|:|.|....:||.||:|:|.  |::.
Mouse  1532 PVARRLLWDTVERVRESGKTIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKF--GISY 1594

  Fly  1364 KLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI-SKDTSWSEIFEYVEGNRSS 1427
            .|...|:......||.:.:..:.:|:|.:.|:::::  ..|.:.: ..:.||:::|..:|..:..
Mouse  1595 SLQAKVRRKWQQQMLEEFKAFVDLTFPGSNLEDEHQ--NMLQYYLPGPNLSWAKVFSIMEQAKKD 1657

  Fly  1428 WHLEDYSLSQPSLEDAF-----------EEIAEER 1451
            :.|||||:||.||||.|           |:|.:|:
Mouse  1658 YMLEDYSISQLSLEDIFLNFTRPESSTKEQIQQEQ 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	115/320 (36%)
		ABC_subfamily_A	339..556	CDD:213230	88/220 (40%)
		ABC2_membrane_3	<821..1018	CDD:289468	57/237 (24%)
		CcmA	1135..1450	CDD:224054	115/330 (35%)
		ABC_subfamily_A	1136..1354	CDD:213230	86/221 (39%)
Abca17	NP_001026792.2	rim_protein	<209..1684	CDD:130324	426/1574 (27%)
Abca17	NP_001026792.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1733		3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4067
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830