DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and CG1494

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster

Alignment Length:	1601	Identity:	362/1601 - (22%)
Similarity:	680/1601 - (42%)	Gaps:	302/1601 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DGSYPLY-KTGFLAVQQALSQ---VHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQD 65
            :|.:..| :.||:.:|:::|:   |...||    :.....|:..||......|:..:.|
  Fly   217 EGGFVGYVREGFIRLQKSVSESFLVLTSHK----SLPTIQIRRFPITGREQDPLMGNLN------ 271

  Fly    66 VGIMIIVIIIFFVVVSL-TKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITL 129
            .|:..|:||.|.....| ...:|.||:.|::..|..|.:|:.:.:|:||::..|..:|.|.||..
  Fly   272 YGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLKGLIYEMISSLIIAA 336

  Fly   130 FWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPF 194
            ..| :..:.:...:..|.|.:.:.||...:...:.|:.::::..........|..:..|.:|:|.
  Fly   337 LLK-IRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVRVLTILWIMSYVPT 400

  Fly   195 LILHSKGCSEGLNV----FLSLFLLSGLQVLVVGICM---------WEDYGEGLQWGNLFETSWP 246
            .||.:.  .|| |:    ::|..|.:.:..||:...:         |||.|        :..::.
  Fly   401 FILSNN--LEG-NIHALRYVSYALPNVVATLVIEFLIERESIVHITWEDSG--------YRLNYD 454

  Fly   247 GGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIF 311
            ||.::|.....:.:|.:.:...:.||::..|.|... .:....|.|.....|.  ||
  Fly   455 GGHITVTASSWIFMLNALVYCAIGLYVDMWRGGDRS-GKKMKKPNTNASVQED--PY-------- 508

  Fly   312 GIYSAAPDEERPD-------------LQLIEPDPVDKIAGVQIRGLSKTFGKME--VVKNVSFDM 361
                    .||.|             .::.|.:|..:...::|:.|.|.|...:  .:...|:::
  Fly   509 --------HERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIKKLCKRFATNDRPALNLFSWNV 565

  Fly   362 FEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHL 426
            :|.::||||||||.||:||:.:|||.:.|:.||.:|:..:|:.||:.|...:|:....::|....
  Fly   566 YENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTERKAASMELGIAFGHDMLLTGF 630

  Fly   427 SSVSHIQLFSRLRGL-RGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKV 490
            :.:.:::...|::|| ...|:..:...:|..|.:...|....|.|:......:|:.|:..|...:
  Fly   631 TVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQIGGLKTKRIRTLTDRDLCLVSICCAFVGNSPI 695

  Fly   491 LICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFL 555
            ::.|:..:.||...:..:|.||.|.|...||:|.::.....|.:.||:.|:|:|:|:|.|:.|||
  Fly   696 ILIDDVHSDLDKRTQSLVWNLINEEKSKRTIILVSNSPALAENIADRMAIMSNGELKCTGTKPFL 760

  Fly   556 KKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLP-LSKSKY---FSSLFR 616
            |........:||...|....::|..:::.::..:   ||: ||:.||:. :.::|:   |..|..
  Fly   761 KNMYGHGYRLTCVKGKNYKRDELFGMMNSYMPNM---SIE-RDIGYKVTFVLENKFEDQFPMLID 821

  Fly   617 DLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDD-RDDDEENEVQDGNVRS 680
            |||..|..|||..|.:...|:||||:.||.||  :.|||..:..::.. ..::..:.:.:.|.:.
  Fly   822 DLEENMQQLGVVSFRIRDTSMEEIFLRFGCED--NDQSGAFQSHENAQVLLEEYYSTLAEANEKG 884

  Fly   681 CKKQW-------RAMMTKKVMALYDNKVYFLLLLLTPIVYYITT---LMMATKPHHSGRPTFNIS 735
            .:..|       ||::.|:.:|.:.:.:..:..:|...:..:.|   :.:..|.:.....|||:|
  Fly   885 RRTGWKLFFLHGRAVIYKRWIAAHRHWIVLIFEVLAMALVAVCTFSSIFIYGKNYELEPLTFNLS 949

  Fly   736 D-YGVDKFTILLSVPVSKSYTEERRAD--------------SIASLIKGK--LKLIVVSEQIKDY 783
            . :.||.|..|.|       .||...|              .:|:|.|.:  ...::...|...:
  Fly   950 QLHTVDAFVELFS-------EEEDVKDMHAYYTELLYWYDAHVATLTKNRHNAYALLTQNQFTAH 1007

  Fly   784 VDDKWKSREGRREINFVSMAIDTGDRTGLIGWVG--PRHYVHAAPMILNLVYNALAQELIGPKIS 846
            |:.:           ::..|  |.|:..:..|..  |   :|:||..||:|:||:|:.|...:.:
  Fly  1008 VNSR-----------YIFGA--TFDQKIVTAWFNNIP---LHSAPYALNVVHNAVARHLFDEEAT 1056

  Fly   847 IEVTSVPFTLRKK-EDFLISNN---GDIPI---YVIGYVSIAMIIFSSAVIQERVSHMKMLQEVS 904
            |:||..|...|.. ..|..|::   |.:..   :|:.::..|..|:   :|.||.|.:|..|.::
  Fly  1057 IDVTLAPLPFRTAINTFPPSSHTFGGCLAFGICFVLTFIWPAFAIY---MITERGSLLKKQQFLA 1118

  Fly   905 GLEMITYWLSHLAFDMVVFFI------LVLALL------LPLYGYAP--------WYLLLCVLF- 948
            |:.:.:||...:.:|::...|      :::||.      :.||||..        |.:||..|.
  Fly  1119 GVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNHDVMLYGYISVTLMLGGFWVILLAYLMA 1183

  Fly   949 ---------FTGLAGL------IFIYFLIS-----MLSATFLAVSMILLSVIIGSLILMILGALA 993
                     |..|.|:      .|..|..:     :|..||:|  |..::.:|..|.::
  Fly  1184 SLCRNPCYGFLWLCGINSIGLVCFSQFYRTHPESMLLEPTFMA--MYTVATVICKLFMI------ 1240

  Fly   994 LIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLE 1058
            ..||::.       |.|::                             |.||.|::..|.:
  Fly  1241 YEFKLIC-------MDPVV-----------------------------NFTSVEVFKCNSI---- 1265

  Fly  1059 PRCVCVNPM-------TWPDMLVMLGTAIILFLLIMFFEYGSCVWYRCKGCCPYSSKGSIEDPKV 1116
            |.| |:...       .:.|::::....|||...:...||.|.:.:   ..|...::.: |.|..
  Fly  1266 PNC-CIKSNYGTFTAGIYHDLVILTLLDIILLACLFVSEYHSILGF---ADCRLDTRTN-ESPDS 1325

  Fly  1117 SREA-----------------EKIRAMDADQIGTRALVVNGVSKKYGCDQLAVNNISFALKPSHC 1164
            ::|:                 |....::.::....|.|..|:..||..::: :.::.|.|..|.|
  Fly  1326 NQESRAFPGILSNDTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRV-LRDLDFTLAKSEC 1389

  Fly  1165 VGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQL 1229
            :.:.|.|.:||||..|::|.|..::.|.::|..||:...|.:..:.:|||||.||.....|.|:|
  Fly  1390 LSITGANNSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPREL 1454

  Fly  1230 LKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEP 1293
            |.:..::.|...:...:..|.|....|.....::.:...:.|..|::..|.| .|:..|||:|..
  Fly  1455 LYIHAMLQGHRHRIGRELSEALLRLVGLTPCWNRSVRMCTTGQIRRLYFAYAVLGSPDLICVDGV 1519

  Fly  1294 SAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIA 1358
            .||:||..:|.:..:.:.:...|.:.|.|.....:...|..::.:|::|.::.:..:........
  Fly  1520 PAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPMDTETENYK 1584

  Fly  1359 KGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQ-------------ISK 1410
            .|..|:          |....|:..::.|:.....|...:..|....|.             |.:
  Fly  1585 SGYQLE----------VRFKRKVNPNVSMSRATWNLINHFPMSPNKKFSAFMEIKFPDAVLTIER 1639

  Fly  1411 D-----------TSWSEIFEYVEGNRSSWHLEDYSLSQPSL 1440
            |           |::||||..:..:....::|||.:::..|
  Fly  1640 DDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNML 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	93/313 (30%)
		ABC_subfamily_A	339..556	CDD:213230	65/219 (30%)
		ABC2_membrane_3	<821..1018	CDD:289468	58/244 (24%)
		CcmA	1135..1450	CDD:224054	77/331 (23%)
		ABC_subfamily_A	1136..1354	CDD:213230	57/218 (26%)
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	50/234 (21%)
		CcmA	541..848	CDD:224054	93/310 (30%)
		ABC_subfamily_A	541..761	CDD:213230	65/219 (30%)
		ABC2_membrane_3	911..>1189	CDD:289468	67/303 (22%)
		ABC2_membrane	<1080..>1188	CDD:304374	25/110 (23%)
		ABC_subfamily_A	1370..1577	CDD:213230	55/207 (27%)
		PRK14255	1371..1586	CDD:172743	54/215 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	9	8.970