DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca15

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_796187.2	Gene:	Abca15 / 320631	MGIID:	2388709	Length:	1668	Species:	Mus musculus

Alignment Length:	1578	Identity:	466/1578 - (29%)
Similarity:	762/1578 - (48%)	Gaps:	229/1578 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YLADGSYPLYKT-GFLAVQQALSQVHIKH-----KCKEFNKTQGDI-----KFPPIKDLPSPPIF 55
            |.|||..|.|.| ||||||.||.:..:.|     ....||    ||     :||       .|.:
Mouse   194 YEADGGSPGYITEGFLAVQHALDKAIMLHHGGADAAALFN----DISLFIQRFP-------YPAY 247

  Fly    56 KSDNSSTLQDVGI-MIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFII 119
            ..|.........| :.:....||....|..|||.|||.:||....::|:.:.:.|||::.....:
Mouse   248 YHDYFYLFATTFIPLTVACTFFFNHYVLVWSIVWEKENRLKEYQLMIGLRNWMFWVAYFFTFLCL 312

  Fly   120 FLIGSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLIS-TTYRISLVT 183
            :.|  :||.:...|.:.........:...::....||..:..:|.|||::|:|.: .:..:||.:
Mouse   313 YFI--NIIVMCMVLFVKIEPAPIFQYNDPTLVFIFLLFYAISSIFFSFMVSTLFNKVSLAMSLGS 375

  Fly   184 FLALIATYLPFLILH-------SKG---CSEGLNVFLSLFLLSGLQVLVVGICMWEDYGEGLQWG 238
            ||..: ||.|.:.:|       ||.   .|...||.::.    |.:.||    ..:....|::|.
Mouse   376 FLFFL-TYFPAVAMHQSFERMPSKQKLIWSFDFNVGMAF----GFRFLV----NTDAKKTGMKWS 431

  Fly   239 NLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPY 303
            |:| .|....:....|:|.:::..:|:..|:..|:|.:.||.||||:||:|          .|.:
Mouse   432 NIF-LSTDSDSFLFAYVLGMLLADAFIYGLVAWYIEAVFPGEYGVPKPWNF----------FLMH 485

  Fly   304 SRLFNRIFGIYSAAPDE--------ERPDLQLIEPDPVDKIAGVQIRGLSKTFGKME----VVKN 356
            |..|..       .|.:        ||.:.:..|.:|.|..||:||:.|.|.|.|..    .:|:
Mouse   486 SYWFGE-------PPQQKLEITQFYERVESKYFEAEPTDLTAGIQIKHLHKVFQKNNTTKVAIKD 543

  Fly   357 VSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNV 421
            :|.:::|||:|||:|||||||:|.:|:|:|...||||.|.::|.||.|...|.:..:|||||||:
Mouse   544 LSLNLYEGQVTVLLGHNGAGKSTTLSILSGLYPPTSGEAYVHGEDISQHMDQVRNSLGLCPQQNL 608

  Fly   422 LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCG 486
            ||.||:...|:..:.|::|:.......|..|.|...||.||....:::||||.:|:|::..:|.|
Mouse   609 LFDHLTVSEHLYFYCRIKGVPQKMYLEETNNMLSAFNLMEKCDAFSKSLSGGMKRKLAIIIALIG 673

  Fly   487 GVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGS 551
            |.||.|.|||::|:||::||..|.::...|:..|||||||.:|:.:|||||:.|:..|.|||.||
Mouse   674 GSKVAILDEPTSGMDPASRRSTWDILQTYKQNRTILLTTHYMDEADVLGDRIAIMVRGTLRCCGS 738

  Fly   552 LPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFR 616
            ..|||:.......:.......||:.:::.||..:|.|....:..|.::.:.||...:..|.:||.
Mouse   739 SVFLKRLYGVGSHLVMVKEPYCDIAEISKLIHSYVPTATLETNVGNELSFILPKEYTHRFEALFT 803

  Fly   617 DLESQMNILGVRGFSLSSVSLEEIFMSF-----GAEDLNSRQSGGAEKRDDDDRDDDEENEV--- 673
            .||.....||:..|.:|..::||:|:..     ...|:.:.||.....:.:.:.|.:....|
Mouse   804 ALEENQENLGISSFGVSITTMEEVFLKVSNLEDSKTDIEATQSPSVGSKGNKNGDVESSGRVGFP 868

  Fly   674 ---QDGNV---RSCK---KQWRAMMTKKVMALYDNKVYFLLLLLTPIVYYITTLMMATKPH---H 726
               :|.|:   ..|.   :|:|||..|::|..:.|....|:.:|..|   |:|.:: .|.|   :
Mouse   869 TQSEDQNIVFNTGCSLYLQQFRAMFMKRLMYNWRNWRGILVQILGLI---ISTFLL-LKSHEFRY 929

  Fly   727 SGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDYVDDKWKSR 791
            ......|:.:||.   ||   ||.| .:.:.....|:.:.::..||  ..:.|:|:...|..|..
Mouse   930 KKIRQMNLDEYGQ---TI---VPFS-IWGKSNLTSSLLTHLENMLK--PGNHQLKEVQGDLLKYL 985

  Fly   792 EGRRE---INFVSMAID-TGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELIGPKISIEVTSV 852
            ||..|   :..::::|. ..:|..|........| |:..:.|.::.|.|...|.|...||.|.:.
Mouse   986 EGNDECVHLCVIALSIKVVANRVNLTVLFNNEAY-HSPSLSLTVLDNILFMSLSGSDASITVFNK 1049

  Fly   853 PFTLRKKEDFLISNNGDIPIYVIGYVSIAMII--FSSAVIQERVSHMKMLQEVSGLEMITYWLSH 915
            |....:::::..|.:|.|..:.| .:.:|:::  |....:.||.:..|.:|.:||:.::.||||.
Mouse  1050 PQPSPQRKEWPGSTDGKIVAFKI-QLGMALLVSGFCILTVTERHNKTKHMQFLSGVSILVYWLSA 1113

  Fly   916 LAFDMVVFFI-----LVL------------------ALLLPLYGYA--PWYLLLCVLFFTGLAG- 954
            |.||:::|||     ||:                  .|:|.|:|::  |...||..||....:.
Mouse  1114 LVFDLIIFFISCCFLLVMFKYCKFDIYVTDYHILDTMLILTLFGWSAIPLTYLLSFLFSKSNSAY 1178

  Fly   955 ---LIFIYF--LISMLSATFLAVSMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAG 1014
               |:|.|.  .:|:|..|.:...  :.:::..|....:|.|| |:|.|.       |:...|:.
Mouse  1179 INLLVFCYLSGTLSLLMDTIIEAR--ISTIMSNSTQTFLLNAL-LLFPMY-------NLGKCISE 1233

  Fly  1015 YNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCI---NPLAFLEPRCVCVNPMTWPDM---- 1072
            |..|.:                         .:|.||   |.|.:|.    |.|..|..::
Mouse  1234 YTVIYR-------------------------KKMLCIQQKNALKYLN----CSNKHTKKNIYSLK 1269

  Fly  1073 -------LVMLGTAIILFLLIMFF----------------EYGSCVWYRCKGCCPYSSKGSIEDP 1114
                   |:.:..|..:|||::||                .:|:|..|: .........|:.||.
Mouse  1270 KPMLGKYLIAMSIAGFVFLLLIFFWENISWKVKMFIHQHIYFGACKKYK-PDIISKELSGTSEDN 1333

  Fly  1115 KVSREAEKIRAMDADQIGTRALVVNGVSKKYGCDQ--LAVNNISFALKPSHCVGLLGPNGAGKTT 1177
            .|..|..:| ....::.....:::..::|.|....  |||.|||.|::...|.||||.|||||||
Mouse  1334 DVENERREI-LYQPEKFLNCPVLIKELTKIYFKSPLILAVKNISLAIQERACFGLLGFNGAGKTT 1397

  Fly  1178 TFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSK 1242
            ||:::.||:....|:::|.|.|:.....|...::|||||.|:..|::||.:::.::..|||....
Mouse  1398 TFQILTGENIPTAGDVFIDGISLTKNIVKVRSKIGYCPQFDALLEYMTGWEIMIMYARIWGISEH 1462

  Fly  1243 DLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVW 1306
            .:....:|..:......|.:..|:.||.|.||:::.|:| .|..|:|.|||||.|:||.:||.:|
Mouse  1463 QIQPYVKKYLNSLDLESHANSLISTYSEGNKRRLSTAIATMGKPSVIFLDEPSTGMDPRARRLLW 1527

  Fly  1307 TIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVVNVQP 1371
            ..:.::.:.|||:::|||:|:|..|||::..|:|.|.:..:||.|::|||......||..|
Mouse  1528 DTVIKIRESGKAIIITSHSMEECEALCTRLSIMVRGRLTCLGSPQYLKNKFGNIYILKAKV---- 1588

  Fly  1372 DNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI-SKDTSWSEIFEYVEGNRSSWHLEDYSL 1435
             .....|.:.::.|.:|:|.:||::  |..|.|.:.| .|:.||.::|..:|..:..::|||||:
Mouse  1589 -KSGETLDEFKNFITLTFPGSELQQ--ENQGILNYCIPRKNNSWGKVFGILEKAKEQYNLEDYSI 1650

  Fly  1436 SQPSLEDAFEEIAEERRK 1453
            ||.:|:..|...|::.||
Mouse  1651 SQITLDQVFLSFADQDRK 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	124/310 (40%)
		ABC_subfamily_A	339..556	CDD:213230	99/220 (45%)
		ABC2_membrane_3	<821..1018	CDD:289468	60/229 (26%)
		CcmA	1135..1450	CDD:224054	114/318 (36%)
		ABC_subfamily_A	1136..1354	CDD:213230	83/220 (38%)
Abca15	NP_796187.2	ABC2_membrane_3	144..464	CDD:289468	77/292 (26%)
		ABC2_membrane	<267..383	CDD:304374	32/118 (27%)
		CcmA	522..831	CDD:224054	122/308 (40%)
		ABC_subfamily_A	522..743	CDD:213230	99/220 (45%)
		ABC2_membrane_3	<1009..1231	CDD:289468	59/233 (25%)
		CcmA	1354..1648	CDD:224054	106/300 (35%)
		ABC_subfamily_A	1354..1575	CDD:213230	83/220 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4067
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830