Protein Alignment CG42816 and Abca1

DIOPT Version :9

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: XP_038965774.1
• Gene: Abca1 / 313210
• RGDID: 631344
• Length: 2263
• Species: Rattus norvegicus
• Alignment Length: 1741
• Identity: 451/1741 - (25%)
• Similarity: 768/1741 - (44%)
• Gaps: 409/1741 - (23%)

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSP----PIFKSDNSSTLQDVGIMIIVII 74
            ||..:|..:.|..|:.......||.     ..::.:|.|    .||....|.::.    :.:.:.
  Rat   592 GFAYLQDVVEQAIIRVLTGTEKKTG-----VYVQQMPYPCYVDDIFLRVMSRSMP----LFMTLA 647

  Fly    75 IFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSE 139
            ..:.|..:.||||.|||.:||.|:.:||:.:.:.|.:|:|.:.|..|:.:.::.:..||.
  Rat   648 WIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFISSLIPLLVSAGLLVIILKLG----- 707

  Fly   140 ISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSE 204
             ..:|::..|:....|.|.:..||...||:|:|.|.|...:....:.....|||:::..:.....
  Rat   708 -DLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRTNLAAACGGIIYFTLYLPYVLCVAWQDYV 771

  Fly   205 GLNVFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILAS 263
            |.::.:...|||      |.:.    ..::|:.|.|:||.|||::.......::...:.:|:..:
  Rat   772 GFSIKIFASLLSPVAFGFGCEY----FALFEEQGIGVQWDNLFKSPVEEDGFNLTTSVSMMLFDT 832

  Fly   264 FLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIYSAAPDEERPDLQL- 327
            |:..::..|:|.:.||.||:|:||:||||:          |..|.......|.....::...::
  Rat   833 FIYGVMTWYIEAVFPGQYGIPRPWYFPCTK----------SYWFGEEIDEKSHPGSSQKGASEIC 887

  Fly   328 IEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISP 390
            :|.:|.....||.|:.|.|.:  |....|..::.:.:|||||..:|||||||||.:|:|.|...|
  Rat   888 MEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPP 952

  Fly   391 TSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLK 455
            |||||.|.|.|||.|....::.:|:|||.||||..|:...||..::||:||....||:|::....
  Rat   953 TSGTAYILGKDIRSEMNSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMAL 1017

  Fly   456 KLNLQEKK-RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGC 519
            .:.|...| :.....||||.||:||||.:..||.||:|.|||:.|:||.:||.:|.|:|:.::|.
  Rat  1018 DVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGR 1082

  Fly   520 TILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV---------------------DASC 563
            ||:|:||.:|:.::||||:.|||.|:|.|:||..|||.|:                     ::|.
  Rat  1083 TIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSS 1147

  Fly   564 LITC-------------------EARKRC----DLEKLTSLISRHVGTIQPFSIKGRDVCYKLPL 605
            .::|                   |.::..    |:..:::||.:||...:.....|.::.|.||.
  Rat  1148 TVSCLKKVVPELPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPY 1212

  Fly   606 SKSK--YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED--------------LNSRQS 654
            ..:|  .|..||.:::.:::.||:..:.:|..:|||||:....|.              .|.|..
  Rat  1213 EAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAF 1277

  Fly   655 GGAEK------RDD--DDRDDDEENEVQDGNVRS---------------CKKQWRAMMTKKVMAL 696
            |..:.      .||  |..|.|.:.|.::.::.|               .::|:.|::.|:::..
  Rat  1278 GDKQSCLHPFTEDDAVDPNDSDLDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIA 1342

  Fly   697 YDNKVYFLLLLLTPIVYYITTLMMA---------------------------------------- 721
            ..::..|...::.|.|:....|:.:
  Rat  1343 RRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPNLELQPWMYNEQYTFVSNDAPEDMGTQELL 1407

  Fly   722 ---TK------------------------------------------------------------ 723
               ||
  Rat  1408 NALTKDPGFGTRCMEGNPIPNTPCLVGEEDWTTGPVPQTLMDLFQNGNWTMKNPSPSCQCSSDKI 1472

  Fly   724 --------PHHSGRPT----------------FNISDYGVDKFTILLSVPV-SKSYTEERR---- 759
                    |...|.|.                .|||||.|..:..:::..: :|.:..|.|
  Rat  1473 KKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKVWVNEFRYGGF 1537

  Fly   760 ----ADS--------IASLIKGKLKLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGL 812
                :||        :.:.||...||:.::   ||...|::.|..||    |:: .:||.:...:
  Rat  1538 SLGVSDSQALPPSQEVNNAIKQMKKLLKLT---KDSSADRFLSSLGR----FMT-GLDTKNNVKV 1594

  Fly   813 IGWVGPRHYVHAAPMILNLVYNAL----AQELIGP-KISIEVTSVPFTLRKK---EDFLISNNGD 869
              |...:.: ||....||::.||:    .|:...| :..|...:.|..|.|:   |..|::.:.|
  Rat  1595 --WFNNKGW-HAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVD 1656

  Fly   870 I-----PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM--------- 920
            :     .|:.:.:|..:.::|   :||||||..|.||.:.|::.:.||||:..:||
  Rat  1657 VLVSICVIFAMSFVPASFVVF---LIQERVSKAKHLQFICGVKPVIYWLSNFVWDMCNYVVPATL 1718

  Fly   921 -VVFFIL-------------VLALLLPLYGYA-----------------PWYLLLCVLFFTGLAG 954
             |:.||.             ||||||.|||::                 .:.:|..|..|.|:.|
  Rat  1719 VVIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGING 1783

  Fly   955 LIFIYFLISMLSATFLAVSMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQ 1019
            .:..:.|....:..|..::.||.||.                              ||..:.|:.
  Rat  1784 SVATFVLELFTNNKFNDINDILKSVF------------------------------LIFPHFCLG 1818

  Fly  1020 KCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAI 1080
            :....| :....:::|.....||.                   .|:|::|.    ::..|....:
  Rat  1819 RGLIDM-VKNQAMADALERFGENR-------------------FVSPLSWDLVGRNLFAMAVEGV 1863

  Fly  1081 ILFLLIMFFEYGSCVWYR-CKGCCPYSSKGSIEDPKVSREAEKIRAMDADQIGTRALVVNGVSKK 1144
            :.||:.:..:|...:..| .|...|..:.   ||..|.||.::|......   ...|.:..::|.
  Rat  1864 VFFLVTVLIQYRFFIRPRPVKARLPPLND---EDEDVRRERQRILEGGGQ---NDILEIKELTKI 1922

  Fly  1145 YGCDQL-AVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAM 1208
            |...:. ||:.|...:.|..|.||||.||||||:||||:.|:.::.:|:..::..|:....::..
  Rat  1923 YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKTSTFKMLTGDTAVTRGDALLNKNSILSNIHEVH 1987

  Fly  1209 KELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTK 1273
            :.:|||||.|:..|.||||:.|:.|.|:.|.|.|::.|..|....:.|..|:.:|..:.||||.|
  Rat  1988 QNMGYCPQFDAITELLTGREHLEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNK 2052

  Fly  1274 RKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSV 1337
            ||::.|:| .|...::.||||:.|:||.:||.:|.....:.::|::|:||||:|:|..|||::..
  Rat  2053 RKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIKEGRSVVLTSHSMEECEALCTRMA 2117

  Fly  1338 ILVDGSIYAMGSVQHVKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFS 1401
            |:|:|....:|||||:||:...|.|:.: :....||     |..:::...:.:|.:.||||:.
  Rat  2118 IMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPD-----LKPVQEFFGLAFPGSVLKEKHR-- 2175

  Fly  1402 GRLTFQI-SKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            ..|.:|: |..:|.:.||..:..::...|:||||:||.:|:..|...|:::
  Rat  2176 NMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	129/355 (36%)
		ABC_subfamily_A	339..556	CDD:213230	101/219 (46%)
		ABC2_membrane_3	<821..1018	CDD:289468	59/249 (24%)
		CcmA	1135..1450	CDD:224054	114/318 (36%)
		ABC_subfamily_A	1136..1354	CDD:213230	86/219 (39%)
Abca1	XP_038965774.1	rim_protein	1..2238	CDD:130324	451/1741 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4008
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830