Protein Alignment CG42816 and Abca4

DIOPT Version :9

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_001101191.1
• Gene: Abca4 / 310836
• RGDID: 1309445
• Length: 2290
• Species: Rattus norvegicus
• Alignment Length: 1727
• Identity: 449/1727 - (25%)
• Similarity: 750/1727 - (43%)
• Gaps: 374/1727 - (21%)

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPI----KDLPSPPIFKSDNSSTLQDVGIMIIVII 74
            ||..:|..:.|..::      ::|..:   |||    :.:|. |.|..|:...:.:....|.:::
  Rat   588 GFAYLQDMVEQGIVR------SQTPAE---PPIGVYLQQMPY-PCFVDDSFMIILNRCFPIFMVL 642

  Fly    75 IFFVVVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNS 138
            .:...||:| |.||.||||:||.||...||.:.:.|..|::.:|.|..:...::|||
  Rat   643 AWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTLF-------- 699

  Fly   139 EISFMPFTHWS--MALFV-LLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSK 200
             |......|:|  ..||: ||..:..||...||.|:..|.....:..:.:.....|||.::..:.
  Rat   700 -IMHGRILHYSDPFILFLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFTLYLPHILCFAW 763

  Fly   201 GCSEGLNVFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVM 259
            ......::..::.|||      |.:.||    .:|:.|.||||.|:.::...|...|....:.:|
  Rat   764 QDRMTADLKTTVSLLSPVAFGFGTEYLV----RFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMM 824

  Fly   260 ILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRC-------CSTESLLPYSRLFNRIFGIYSAA 317
            :|.:.|..||..||:::.||.||.|.||:|.....       |||..    .|...:...:....
  Rat   825 LLDAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTRE----ERALEKTEPLTEEI 885

  Fly   318 PDEERPDLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTL 380
            .|.|.|:....|.:....:.||.::.|.|.|  |....|..::...:|.|||..:|||||||||.
  Rat   886 EDPEYPEDSFFERELPGLVPGVCVKNLVKVFEPGSRPAVDRLNITFYENQITAFLGHNGAGKTTT 950

  Fly   381 ISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAE 445
            :|:|.|.:.|||||.||.|.||.......::.:|:|||.|:||.||:...||..:::|:|....|
  Rat   951 LSILTGLLPPTSGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEE 1015

  Fly   446 VKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWR 510
            .:.|::..|:...|..|:...|::||||.||:||||.:..|..||::.|||::|:||.:||.:|.
  Rat  1016 ARLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWD 1080

  Fly   511 LILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLIT--------- 566
            |:|:.:.|.||:::||.:|:.::||||:.|||.|:|.|.|:..|||........:|
  Rat  1081 LLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQ 1145

  Fly   567 -----CEARKRC------------------------DLEKLTSLISRHVGTIQPFSIKGRDVCYK 602
                 ||....|                        |:::||.|:..||...:.....|:::.:.
  Rat  1146 SQRCGCEGACSCTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEAKLVECIGQELIFL 1210

  Fly   603 LPLS--KSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQS--GGAEKRDD- 662
            ||..  |.:.::||||:||..:..||:..|.:|...|||||:.. .||..|...  ||.:::.:
  Rat  1211 LPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKV-TEDSESGSKFVGGTQQKREH 1274

  Fly   663 -----------------------------DDRDDDEENEVQDGNV------RSCKKQWRAMMTKK 692
                                         |........|.:|..:      |...:..:|::.|:
  Rat  1275 TGLRHPCSAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIPFNTGARLILQHVQALLVKR 1339

  Fly   693 VMALYDNKVYFLLLLLTPIVYYITTLMMA----------------------------TKPHHS-- 727
            ......::..|:..::.|..:....||::                            .:|::.
  Rat  1340 FHHAVRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQFTFFSMDEPNNEHL 1404

  Fly   728 --------GRPTF---------------------------------------------------- 732
                    .||.|
  Rat  1405 EVLADVLLNRPGFGNRCLKEEWLPEYPCGNATSWKTPSVSPNITHLFQKQKWTAAHPSPACKCST 1469

  Fly   733 ------------------------------------NISDYGVDKFTILL-SVPVSKSYTEERRA 760
                                                |||||.|..:..|: |...||.:..|:|.
  Rat  1470 REKLIMLPECPEGAGGLPPPQRIQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRY 1534

  Fly   761 DSIASLIKGKLKLIVVS-EQIKDYVDDKWK---------SREGRREINFVSMAIDTGDRTGLIGW 815
            ..|:  |.|||..|.:| |.:..::.|..:         :||..||:......::|.|...:  |
  Rat  1535 GGIS--IGGKLPDIPISGEALVGFLSDLGQMMNVSGGPVTRESSREMLDFLKHLETKDNIKV--W 1595

  Fly   816 VGPRHYVHAAPMILNLVYNALAQELIGPK------ISIEVTSVPFTLRKK---EDFLISNNGD-- 869
            ...:.: ||....||:.:||:.:..: ||      ..|.|.|.|..|.|:   |..:::.:.|
  Rat  1596 FNNKGW-HALVSFLNVAHNAILRASL-PKDRDPEEYGITVISQPLNLTKEQLSEITVLTTSIDAV 1658

  Fly   870 IPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFILVLALLLPL 934
            :.|.||..:|.....|...:|||||:..|.||.:||:...|||:::..:|::.:.:
  Rat  1659 VAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMTNFLWDIMNYAV--------- 1714

  Fly   935 YGYAPWYLLLCVLFFTGLAGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMILGALALIFKM- 998
                          ..||...|||.|.....::|....:::.|.::.|..::.::...:.:|.:
  Rat  1715 --------------SAGLVVGIFIGFQKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFLFDVP 1765

  Fly   999 --VYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSEN--------LTSDEMYCINP 1053
              .|||:..||   |..|.|         |...:::.|    |.||        .|..|:..:.|
  Rat  1766 STAYVALSCAN---LFIGIN---------SSAITFVLE----LFENNRMLLRFSATLRELLIVFP 1814

  Fly  1054 LAFLEPRCV-------------------CVNPMTW----PDMLVMLGTAIILFLLIMFFEYGSCV 1095
            ...|....:                   ..||..|    .:::.|....::.|||.:..::...:
  Rat  1815 HFCLGRGLIDLALSQAVTDIYAQFGEEYSANPFQWDLIGKNLVAMAIEGVVYFLLTLLIQHHFFL 1879

  Fly  1096 --WYRCKGCCPYSSKGSIEDPKVSREAEKIRAMDADQIGTRA--LVVNGVSKKY-GCDQLAVNNI 1155
              |.    ..|.......||..|:.|.:::.:.     |:::  |.:|.::|.| |....||:.:
  Rat  1880 TRWI----AEPAREPVFDEDDDVAEERQRVMSG-----GSKSDILKLNELTKVYSGSSSPAVDRL 1935

  Fly  1156 SFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSF 1220
            ...:.|..|.||||.|||||||||||:.|:.::..|:..|:|.|:....:...:.:|||||.|:.
  Rat  1936 CVGVHPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATIAGKSILTNISDVHQNMGYCPQFDAI 2000

  Fly  1221 FEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGA 1284
            .:.||||:.|.::..:.|.|||::.|.........|...:.|:....||||.|||::.|:| .|.
  Rat  2001 DDLLTGREHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGC 2065

  Fly  1285 NSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGS 1349
            ..|:.||||:.|:||.:||.:|..|..:.:||:||:||||:|:|..|||::..|:|.|:...||:
  Rat  2066 PPLLLLDEPTTGMDPQARRMLWNTIVNIIRQGRAVVLTSHSMEECEALCTRLAIMVKGTFQCMGT 2130

  Fly  1350 VQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKDTSW 1414
            :||:|.|...|..:.:.:....|:::..|..:|......:|.:..:|::.  ..|.||: ..:|.
  Rat  2131 IQHLKYKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHH--SMLQFQV-PSSSL 2192

  Fly  1415 SEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            :.||:.:..::.|..:|:||::|.:|:..|...|:::
  Rat  2193 ARIFQLLISHKDSLLIEEYSVTQTTLDQVFVNFAKQQ 2229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	125/348 (36%)
		ABC_subfamily_A	339..556	CDD:213230	93/218 (43%)
		ABC2_membrane_3	<821..1018	CDD:289468	53/210 (25%)
		CcmA	1135..1450	CDD:224054	111/318 (35%)
		ABC_subfamily_A	1136..1354	CDD:213230	89/219 (41%)
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	449/1727 (26%)
		ABC_subfamily_A	907..1126	CDD:213230	93/218 (43%)
		ABC_subfamily_A	1915..2135	CDD:213230	89/219 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4008
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730