DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca8a

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001268753.1	Gene:	Abca8a / 303638	RGDID:	1307333	Length:	1615	Species:	Rattus norvegicus

Alignment Length:	1596	Identity:	411/1596 - (25%)
Similarity:	685/1596 - (42%)	Gaps:	331/1596 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YKTGFLAVQQALS----QVHIKHK-CKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMI 70
            ::.||:|:|.|::    :|...|. .:|.....|  |:..|....:       ...|..|..:.:
  Rat   173 WRHGFVALQAAINSAIIEVTTNHSVMEEMMSLTG--KYIKIDSFIA-------QEGTTTDYFLFL 228

  Fly    71 IVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAW-YIQTFIIFLIGSSIITLFWKLV 134
            .:|....:...::..:..|:: ::|..:.:||:.....|::| .:...|:|     |:|||...|
  Rat   229 CIIAFSPLTYYISAGVTRERK-KMKAFMTVMGLRDSAFWLSWGLLYGVIVF-----IVTLFLTFV 287

  Fly   135 LPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTF----------LALIA 189
            :.:.:..||.......:||....||  .|..|||||.|:..::...||.|          .|.:.
  Rat   288 VYSVQFVFMTGFMMIFSLFFFYGLS--LISLSFLMSVLLKKSFLTDLVVFFLTVSCGSLGFAALY 350

  Fly   190 TYLPFLILHSKGCSEGLNVFLSL-----FLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGT 249
            .|||.          .|...|||     |:|...|:|.:      ||       :|..:..|.|.
  Rat   351 RYLPV----------SLEWLLSLLSPFAFMLGMTQLLRL------DY-------DLESSGHPTGN 392

  Fly   250 LSVGYILLVMILASF---LSLLLCLYLEKIRPGPYGVPQPWHF-----------PCTRCCSTESL 300
            .:|  ::..:.|..|   ..|:|..|.||:.||.||...|..|           |..|     ::
  Rat   393 PNV--VIATVFLLFFDGVFYLMLTFYFEKVLPGEYGRRHPPLFFLKSSFWTGQNPADR-----TV 450

  Fly   301 LPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAG---VQIRGLSKTF----GKMEVVKNVS 358
            |...|             |.|.|| ...||...| ..|   ::||.|:|.:    .:.|.:|:::
  Rat   451 LDNER-------------DYEFPD-DSFEPVSTD-FHGKEVIRIRNLTKEYIQRSKRTEALKDLT 500

  Fly   359 FDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALI--NGFDIRQERRQAQRCIGLCPQQNV 421
            .|:::||||.::||:||||:||:::|:|...||.|...|  |......:.....:..|:|||.||
  Rat   501 LDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHDNKLSEMTDLESISKLTGVCPQCNV 565

  Fly   422 LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCG 486
            .|..|:...:::||::::|::  ||.:|||..|..|.::..:....:|||||.:|:|:...::.|
  Rat   566 QFDFLTVRENLRLFAKIKGIQ--EVDNEVQRVLLALEMKNIQNTLVQNLSGGQKRKLTFGIAILG 628

  Fly   487 GVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGS 551
            ..::.:.|||:.||||.:|..:|.|:.|.|....:|.:|..:|:.::|.||.|.||.|:|||.||
  Rat   629 DPQIFLLDEPTAGLDPFSRHRVWNLLKERKADRVVLFSTQFMDEADILADRKVFISQGKLRCAGS 693

  Fly   552 LPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFR 616
            ..||||:......::.:..:.|..|::|||:.:|:...:..:.....:.|.|||.::..|..|:|
  Rat   694 SLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESEGKLNYILPLERTNKFPDLYR 758

  Fly   617 DLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDDDEENEVQDGNVRSC 681
            ||| :...||:..:.:|..:|.|:|:..             |.:...|.|..|..:||.|..|..
  Rat   759 DLE-RCPDLGIENYGVSVTTLTEVFLKL-------------EGKSAIDSDIGETEDVQAGGTRGP 809

  Fly   682 KK----QWRAMM-----TKKVMAL-----------------YDNKVYFLLLLLTPI-VYYITTLM 719
            .:    |:.:::     ||..|||                 |..|...:|:|:..| :.:|
  Rat   810 GRLDGEQFVSLLNEMSKTKGGMALWWQQLCAVTRLRFLKLKYRRKSIVILILILGIGLLHI---- 870

  Fly   720 MATKPHHSGRPTFNISDY--GVDKFTILLS------VPVSK----SYTEERRADSIASLIKGKLK 772
            ::...|.    ..|.|||  .:...|..|:      :|::.    :.|.|:..|.:.||.:..:.
  Rat   871 LSANVHR----LVNQSDYCWELSPHTYFLTPGQRPQMPLTNLLIINKTGEKIDDFLHSLEQQNIA 931

  Fly   773 LIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHY----------VHAAPM 827
            |.|          |.:.:|.|..:..:....|..|         |.::|          ::..|:
  Rat   932 LEV----------DAFGTRNGTEDSQYNGAIIVAG---------GEKNYNFTLACNTKRLNCFPV 977

  Fly   828 ILNLVYNALAQELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSAV--- 889
            ::::|.|||. .|..|.:.|:.....|    .||     .|....|.:.|: .:.|:..:.|
  Rat   978 LVDIVSNALL-GLFTPSVHIQTDRSSF----PED-----TGYTQFYHLLYM-FSWILLMACVPPY 1031

  Fly   890 -----IQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFILVLALLLPLYGYAP-------WYL 942
                 |.:..:..:....:|||....||..|..|::.|:..|:|::.:..|..||       ..|
  Rat  1032 ISMTSIDDYKNRAQFQLWISGLSPSAYWFGHALFEIPVYSALILSVYIAFYFSAPPESMITTRDL 1096

  Fly   943 LLCVLFFTGLA-GLIFIYFLISML-----------SATFLAVSMILLSVIIGSLILMILGALALI 995
            .:.:|:..|.| .:||:.::||.:           |..|..||.|       ||.||:.......
  Rat  1097 FIQILYAGGYAMSVIFMMYVISFICRKGRKNSGIWSLCFYIVSFI-------SLCLMLFKFFEDT 1154

  Fly   996 FKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPR 1060
            |....:|:.     |::....|  ...|:.:          :...|.....|.| ...|.||.|
  Rat  1155 FLFSSIALI-----PVVTLVGC--TLLHFQN----------HEFPEISLYPERY-YTYLFFLAP- 1200

  Fly  1061 CVCVNPMTWPDMLVMLGTAIILFLLIMFF------EYGSCVW-----YRCKGCC------PYSSK 1108
                               ...||:.:|.      ::|....     :|.....      |...:
  Rat  1201 -------------------FFHFLIFLFILRCLERKFGMKTMRMDPVFRISSRSDRVFNNPEEPE 1246

  Fly  1109 GSIEDPKVSREAEKIRAMDADQIGTRALVVNGVSKKY----------GCDQLAVNNISFALKPSH 1163
            |..||..:.|.........||......::.:.:.|:|          |..::|..|||..::...
  Rat  1247 GEDEDVSLERVRTANALTSADFQEKPVIIASCLRKEYKGKKKCFVLKGKKKIATRNISLCVRKGE 1311

  Fly  1164 CVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQ 1228
            .|||||.|||||:|:.|||.||.....|.:.:.|.|    .....:.||||||.::.::.:|.|:
  Rat  1312 VVGLLGHNGAGKSTSIKMITGEIKPSAGQVQLKGNS----TGDTPEFLGYCPQENALWQHMTVRE 1372

  Fly  1229 LLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDE 1292
            .|::|..|.|....|......:|||....:..|...:...|.|.|||:...:: .|..|::.|||
  Rat  1373 HLEIFAAIKGMSKSDAAVAIARLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDE 1437

  Fly  1293 PSAGVDPASRRHVWTIINEV-AQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNK 1356
            ||.|:||..::.:|..|... |...:..|||:|.|.|..|:|.:..|:|.|.:..:||:||:|:|
  Rat  1438 PSTGMDPEGQQQMWQAIQATFANTERGALLTTHYMAEAEAVCDRVAIMVSGKLRCIGSIQHLKSK 1502

  Fly  1357 IAK----GMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKD--TSWS 1415
            ..|    .|.:|....|:|.||         :|...:|.|..:|:|  |..:.:::.::  ...|
  Rat  1503 FGKEYLLEMKVKTPTQVEPLNM---------EIMRLFPQAARQERY--SSLMVYKLPREDVQPLS 1556

  Fly  1416 EIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            :.|..:|..:.|:.||:|||||.:||..|.|:::|:
  Rat  1557 QAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	106/315 (34%)
		ABC_subfamily_A	339..556	CDD:213230	80/222 (36%)
		ABC2_membrane_3	<821..1018	CDD:289468	51/233 (22%)
		CcmA	1135..1450	CDD:224054	106/332 (32%)
		ABC_subfamily_A	1136..1354	CDD:213230	76/229 (33%)
Abca8a	NP_001268753.1	ABC2_membrane_3	27..416	CDD:289468	65/284 (23%)
		DUF4149	267..354	CDD:290390	26/93 (28%)
		ABC_subfamily_A	477..698	CDD:213230	80/222 (36%)
		drrA	493..787	CDD:130256	101/309 (33%)
		ABC2_membrane_3	<1005..1155	CDD:289468	38/162 (23%)
		CcmA	1272..1591	CDD:224054	106/333 (32%)
		ABC_subfamily_A	1279..1500	CDD:213230	76/224 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820