DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca7

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_997481.1	Gene:	Abca7 / 299609	RGDID:	1303134	Length:	2170	Species:	Rattus norvegicus

Alignment Length:	1721	Identity:	434/1721 - (25%)
Similarity:	765/1721 - (44%)	Gaps:	366/1721 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIIIFFV 78
            ||:.:|..|.|..::......::....::..|      .|.:..|....:....:.:.:.:.:..
  Rat   500 GFVYLQDLLEQAAVRVLSGRDSRAGLYLQQMP------HPCYVDDVFLRVLSRSLPLFLTLAWIY 558

  Fly    79 VVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSEISF 142
            .|:|| |::|.|||.:|:.|:..||:...:.|:.|::.....||:.::::.|..||.      :.
  Rat   559 SVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG------NI 617

  Fly   143 MPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSEGLN 207
            :|::|..:....|...:..|:..|||:|:..|.....:....||..|.|||:::..:......|.
  Rat   618 LPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLPLG 682

  Fly   208 VFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGT------LSVGYILLVMI 260
            ..|::.|||      |.:    .:.:.|:.|:|.||.||       ||      .|:..:...::
  Rat   683 GLLAVSLLSPVAFGFGCE----SLALLEEQGDGAQWHNL-------GTGPAEDVFSLAQVSAFLL 736

  Fly   261 LASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIYSAAPDEERPDL 325
            |.:.:..|...|||.:.||.||:|:||:||..|........|.|.:.         ||..:.|.:
  Rat   737 LDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVL---------APAPQDPKV 792

  Fly   326 QLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFI 388
             |:|..|...:.||.||||.|.|  .....::.::.|.:||.||..:|||||||||.:|:|:|..
  Rat   793 -LVEEPPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLF 856

  Fly   389 SPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNY 453
            .|:||:|.|.|.|::......:..:|:|||.||||..|:...|:..:.||:|:..|.:.||.::.
  Rat   857 PPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAIDSEQEHL 921

  Fly   454 LKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEG 518
            ::.:.|..|:....|:||||.||:||||.:..||.:|:|.|||:.|:||::||.:|.|:|:.:||
  Rat   922 IRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREG 986

  Fly   519 CTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV----------DASCLITCEAR--- 570
            .|::|:||.||:.|:|||||.:::.|.|.|.||..||::.:          .:..|:|.:.:
  Rat   987 RTLILSTHHLDEAELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDLKGDT 1051

  Fly   571 ------KRCDLEKLTS--------------------------------LISRHVGTIQPFSIKGR 597
                  |:...|..|:                                |:.|||...|.......
  Rat  1052 EDPRREKKSGSEGKTADTVLTRDGPHRSSQVPAPDAVPVTPSAALILELVQRHVPGAQLVEELPH 1116

  Fly   598 DVCYKLPLSKS--KYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKR 660
            ::...||.:.:  ..|:::|::|:.|:..||:.|:.:|..:|||||:.. .|:.::...||..::
  Rat  1117 ELVLALPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIFLKV-VEEAHAHGEGGDPRQ 1180

  Fly   661 DD-------DDRDDDEENEVQDGNVR------------------------SCKKQWRAMMTKKVM 694
            ..       ......|.:.:::|.:.                        :| :|.||::.|:.:
  Rat  1181 QQHLLTATPQPHTGPEASVLENGELAKLVLDPQAPKGSAPTTAQVQGWTLTC-QQLRALLHKRFL 1244

  Fly   695 ----------------ALYDNKVYFLLLLLTPIVYY----ITTLMMATK---------------- 723
                            ||:.....|..|::.|...|    ::..|...:
  Rat  1245 LARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPADPNRMK 1309

  Fly   724 -------------PHHSGRP------TFNISDYGVDKFTI------LLSVPVSKSYTEERRADSI 763
                         |...|:.      |.:::.|    ||:      :.|:..|.::|.:..:.:.
  Rat  1310 LLEALLGEAGLQDPSVQGKGSRGSECTHSLACY----FTVPEVPPDVASILASGNWTPDSPSPAC 1370

  Fly   764 ASLIKGKLKLI-------------------------VVSEQIKDYV-------------DDKWK- 789
            .....|..:|:                         :....:.|::             ..||.
  Rat  1371 QCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVD 1435

  Fly   790 -------SREGR-------REI------------------------NFVSMAIDTGDRTGLIGWV 816
                   |..||       ||:                        |....|:....|..|..|.
  Rat  1436 EVRYGGFSLGGRDPDLPSGREVVRTVAEMRALLSPQPGNTLDRILNNLTQWALGLDARNSLKIWF 1500

  Fly   817 GPRHYVHAAPMILNLVYNALAQELIGPKISI----EVTSV--PFTLRKK---EDFLISNNGD--I 870
            ..:.: ||....:|...|.|.:..: |..|:    .:|::  |..|.|:   |..||:::.|  :
  Rat  1501 NNKGW-HAMVAFVNRANNGLLRAFL-PSGSVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLV 1563

  Fly   871 PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFILVLALLLPLY 935
            .|.|:..:|.....|:..:|:||::..|.||.||||....|||.:..:||..:.:.|..::|...
  Rat  1564 SICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVLIFL 1628

  Fly   936 GY----------APWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAVSMILLSVIIGS----LI 985
            .:          .|..|||.:|:...:..|:: ..|..|:.|..::.::.|.|.:.|.|    .:
  Rat  1629 AFQQKAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATFV 1693

  Fly   986 LMILG-----ALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTS 1045
            |.:|.     .::.|.|.|:          ||..:.|:.:     .|.....::|.....|.| .
  Rat  1694 LELLSDQNLQEVSRILKQVF----------LIFPHFCLGR-----GLIDMVRNQAMADAFERL-G 1742

  Fly  1046 DEMYCINPLAFLEPRCVCVNPMTW----PDMLVMLGTAIILFLLIMFFEYGSCVWYRCKGCCPYS 1106
            |:.:              .:|:.|    .::|.|:....:..|:.:..::.:.:..:.|...| .
  Rat  1743 DKQF--------------QSPLRWDIIGKNLLAMVAQGPLFLLITLLLQHRNRLLPQPKSRLP-P 1792

  Fly  1107 SKGSIEDPKVSREAEKIR--AMDADQIGTRALVVNGVSKKY-GCDQLAVNNISFALKPSHCVGLL 1168
            ..|. ||..|.||.|::.  |...|     .||:..::|.| |....||:::...:.|..|.|||
  Rat  1793 PLGE-EDEDVVRERERVTKGATQGD-----VLVLRDLTKVYRGQRSPAVDHLCLGIPPGECFGLL 1851

  Fly  1169 GPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVF 1233
            |.||||||:||:|:.|:.....|...::|:::..:.:.|.:.:|||||||:.|:.||||:.|::|
  Rat  1852 GVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQEPSAAHRSMGYCPQSDAIFDLLTGREHLELF 1916

  Fly  1234 LLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGV 1297
            ..:.|.|...:.:.......:.|...:.|:....||||.|||:..|:| .|..:::.||||:.|:
  Rat  1917 ARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGM 1981

  Fly  1298 DPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMT 1362
            ||::||.:|..:..|.::|::|:||||:|:|..|||::..|:|:|....:||.||:|::...|.|
  Rat  1982 DPSARRFLWNNLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSAQHLKSRFGAGHT 2046

  Fly  1363 LKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI--SKDTSWSEIFEYVEGN 1424
            |.| |...||:..:|.       |..|:|:|||:|.:  ..||.||:  ....:.:.:|..:...
  Rat  2047 LTLRVPPDQPEPAIAF-------IVTTFPDAELREVH--GSRLRFQLPPGGGCTLARVFRELAAQ 2102

  Fly  1425 RSSWHLEDYSLSQPSLEDAFEEIAEERRKKK 1455
            ..:..:||:|:||.:||:.|...::::.:::
  Rat  2103 GKAHGVEDFSVSQTTLEEVFLYFSKDQGEEE 2133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	122/361 (34%)
		ABC_subfamily_A	339..556	CDD:213230	95/218 (44%)
		ABC2_membrane_3	<821..1018	CDD:289468	56/227 (25%)
		CcmA	1135..1450	CDD:224054	112/319 (35%)
		ABC_subfamily_A	1136..1354	CDD:213230	83/219 (38%)
Abca7	NP_997481.1	rim_protein	1..2127	CDD:130324	434/1713 (25%)
		ABC2_membrane	<557..742	CDD:304374	51/201 (25%)
		ABC_subfamily_A	805..1024	CDD:213230	95/218 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1086		4/41 (10%)
		ABC_subfamily_A	1818..2038	CDD:213230	83/219 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2129..2170		0/5 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	158	1.000	Domainoid score	I4008
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730