DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca13

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_038948786.1	Gene:	Abca13 / 289797	RGDID:	1305895	Length:	5037	Species:	Rattus norvegicus

Alignment Length:	1572	Identity:	421/1572 - (26%)
Similarity:	714/1572 - (45%)	Gaps:	277/1572 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LQDVGIM--IIVIIIFFV-VVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGS 124
            |.:||..  :|:::.:.| |.|:.:.:|.|:|:|::..:.:||:...:.:::|:::......:.|
  Rat  3539 LNNVGFFFPLIMMLTWMVSVASMVRKLVYEREIQIEEYMRIMGLHPVIHFLSWFLENMATLALSS 3603

  Fly   125 SIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSH---CTICFSFLMSSLISTTYRISLVTFLA 186
            :.:.|..|:    |.|    |.| |.|..:.|.|.:   ..:..|:.:|...:.....:|.|.|.
  Rat  3604 AALALILKM----SGI----FMH-SDAFIIFLYLLNFGVSAVMLSYFLSVFFNKANTAALCTSLG 3659

  Fly   187 LIATYLPF---LILHSKGCSEGLNVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGG 248
            .:.::||:   |:||:: .|..|...|.|...:.....|..|...|...||:||||::....|||
  Rat  3660 YMISFLPYVVLLVLHNQ-LSFALQTLLCLLSTTAFGQGVFFITFLEGQEEGIQWGNMYRAPEPGG 3723

  Fly   249 TLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCT-------------RCCSTESL 300
             ::.|::..:::..|.|..|...|...:.||.:|:.:||:||.|             |.||..|.
  Rat  3724 -MTFGWVCWMILFDSILYFLGGWYFSNLVPGTFGLGKPWYFPFTASYWKSICGLMERRRCSLSSG 3787

  Fly   301 LPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQIRGLSKTFGKMEV-VKNVSFDMFEG 364
            |.:   ||..||....:......:::...|       ||.:..::|.:...:| |:.::......
  Rat  3788 LFF---FNEDFGNKGLSQQNGPGEMEGGSP-------GVALISVTKEYEDHKVAVQELTLTFHRD 3842

  Fly   365 QITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSV 429
            |||.|:|.|||||||:||||.|...|||||.::||.:::.:..:.:..:|:|||.:||..:|:..
  Rat  3843 QITALLGTNGAGKTTIISMLMGLFPPTSGTIIVNGKNLQTDFSKVREELGVCPQHDVLLDNLTVR 3907

  Fly   430 SHIQLFSRLRG--LRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLI 492
            .|:.||:.::.  ....|::.:|...|:::.|.:.:...||.||||.:|:||:..:..|..|.::
  Rat  3908 EHLMLFASIKAPWWTNKELRQQVNKTLEEVELTQHQHKPARVLSGGMKRKLSIGIAFMGMSKTVV 3972

  Fly   493 CDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKK 557
            .||||:|:||.:||.||.::|:.::|.||:.|||.||:.|||.|.|.::..|:|||......||:
  Rat  3973 LDEPSSGVDPCSRRSLWNILLKYRKGRTIIFTTHHLDEAEVLSDHVAVLQQGRLRCYAPPAGLKE 4037

  Fly   558 QVDASCLIT-------CEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSK-YFSSL 614
            .......:|       .|:::..|:.::||||..::.........|.::.|.:|....| .|..|
  Rat  4038 TYGQGLTLTLSKQPSVLESQEPKDVARVTSLIQVYIPQAFLKDSNGGELTYTIPKDADKTCFKGL 4102

  Fly   615 FRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDDDEENEVQDGN-V 678
            .:.|:..:..|.:.|:.:|..:|||:|:.. .:|.|.:      .....|...:.:||...|. :
  Rat  4103 CQALDQNLQHLHLTGYGISDTTLEEVFLML-LQDTNKK------SYITPDNKLESQNEKPVGPCL 4160

  Fly   679 RSCKKQWR---------------------AMMTKKVMALYDNKVY-------FL----------L 705
            |.|....|                     |::.|::  |:..:.:       ||          |
  Rat  4161 RHCGSLMRTLPDSLPEPMGGCQLLLGQAGALLRKRL--LHTLRAWKSTTSDLFLPVLFVALAMGL 4223

  Fly   706 LLLTPIVYYITTLMMATKPHHSGRPT--FNISDYGVDKFTILL-----SVPVSKS---------- 753
            .::.|:......|.: |..|:.....  |:..::..|...:||     ..||...
  Rat  4224 FMVQPLAITYPPLKL-TPGHYETAEAYFFSSGNHDPDLTHVLLRRFGDQDPVCSDAQWVNSSSWH 4287

  Fly   754 ---YTEERRADSIASL--------------IKGKLKLIVVSEQIKDY-VDDKWKSREGRREINFV 800
               |:.....||...|              ..|...|.:....:::| :....|.|.|..... |
  Rat  4288 RDPYSGPEFQDSCGCLKCPNKSAGAPYLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFG-V 4351

  Fly   801 SMAIDTGD--------RTGLIGWVGPRHYVHAAPMILNLVYNAL------AQELIGPKISIEVTS 851
            .:..:..|        :|....|...:.: |:.|..||.:.|.:      |......:..|.:.|
  Rat  4352 QIPNEAEDVKTNTSKPKTLAKVWYNQKGF-HSLPSYLNHLNNLILWQNLPAHAADWRQYGITLYS 4415

  Fly   852 VPF--TLRKKEDFL--ISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYW 912
            .|:  .|..::..|  |...|.....|:|: ||......|:|:::||:..|.||.:|||...|||
  Rat  4416 HPYGGALLNEDRILESIRQCGVALCIVLGF-SILSASIGSSVVKDRVTGAKRLQHISGLGYRTYW 4479

  Fly   913 LSHLAFDMVVFFILV-----------------------LALLLPLYGYA--PWYLLLCVLF---- 948
            |.:..:||:.:.:.|                       .||||.|:|||  ||..|:..:|
  Rat  4480 LINFLYDMLFYLVSVCLCVAIIAAFQLTAFTFRENLAATALLLALFGYAMIPWMYLISRIFSSSD 4544

  Fly   949 --FTGLAGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHP- 1010
              |.....|.||:.|.:||..|.             ..:|.|:.....:.|:..|..:|..:.|
  Rat  4545 VAFISYISLNFIFGLCTMLMTTM-------------PRLLAIISKAQSLQKIYDVLKWVFTIFPQ 4596

  Fly  1011 LIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWPDM-LV 1074
            ...|...|:.|:          ::.:..|:.|...|..  ::|..        :|.:.|..: |.
  Rat  4597 FCLGQGLIELCY----------NQIKYDLTHNFGIDSY--VSPFE--------INFLGWIFVELT 4641

  Fly  1075 MLGTAIILFLLIMFFEYGSCV-WYRCKGCCPYSSKGSIEDP--KVSREAEKIRAMDADQIGTRAL 1136
            :.||.::|..:::   :|.|: |.|     .:|:...|..|  .:..|.|::|.::. :.|...|
  Rat  4642 LQGTFLLLLRILL---HGDCLRWPR-----GHSALQDIVKPVKDIDVEKEQMRVLEG-RTGGDML 4697

  Fly  1137 VVNGVSKKYG--C--DQLAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISG 1197
            |:..:||.|.  |  ...||:.||..:....|.||||.|||||:||||::.||....      ||
  Rat  4698 VLCNLSKSYRGVCRGKTTAVHGISLGISRGECFGLLGVNGAGKSTTFKILNGETPPS------SG 4756

  Fly  1198 YSMRMKRNKAMKEL----------GYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLA 1252
            |:........|.:|          |||||.|:..|.|||.:.|:.:..:.|.|.:::.:....|.
  Rat  4757 YATIRTPQGDMVDLASAGKVGVLIGYCPQQDALDELLTGWEHLQYYCRLRGIPKQNIPEVAADLV 4821

  Fly  1253 DQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQG 1316
            .:.....|:||.:..|||||:||::.|:| .|...::.|||||:|:||.|:|::|..|.:..:.|
  Rat  4822 RRLHLELHVDKPVATYSGGTRRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTITQEVRDG 4886

  Fly  1317 KAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKI 1381
            .|.:||||:|:|..|||::..|:||||...:||.||:||:...|.|:|:.::.:.....|    :
  Rat  4887 CAAVLTSHSMEECEALCTRLAIMVDGSFRCLGSPQHIKNRFGDGYTVKVWLHKEGSQPSA----V 4947

  Fly  1382 EDDIYMTYPNAELKEKYEFSGR----LTFQISKDTSWS---EIFEYVEGNRSSWHLEDYSLSQPS 1439
            .|.:.:.:|.      .:|.|:    |.:.:.|  ||.   ::|..:|.|:|...:|.||:||.:
  Rat  4948 SDCLKLHFPG------IQFKGQRLNLLEYHVQK--SWECLPDLFRVLETNKSLLKIEHYSISQTA 5004

  Fly  1440 LEDAFEEIAEER 1451
            ||..|...|.|:
  Rat  5005 LEQVFVNFATEQ 5016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	106/317 (33%)
		ABC_subfamily_A	339..556	CDD:213230	82/219 (37%)
		ABC2_membrane_3	<821..1018	CDD:289468	61/238 (26%)
		CcmA	1135..1450	CDD:224054	117/336 (35%)
		ABC_subfamily_A	1136..1354	CDD:213230	90/232 (39%)
Abca13	XP_038948786.1	rim_protein	1..>82	CDD:130324
Abca13	XP_038948786.1	rim_protein	3042..5029	CDD:130324	421/1572 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920