DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca5

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_775429.1	Gene:	Abca5 / 286970	RGDID:	628661	Length:	1642	Species:	Rattus norvegicus

Alignment Length:	1611	Identity:	397/1611 - (24%)
Similarity:	705/1611 - (43%)	Gaps:	321/1611 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YKTGFLAVQQALSQVHIKHKC-----KEFNKTQ----GDIKFPPIKDLPSPPIFKSDNSSTLQDV 66
            :.:||.|:|.::....|:.|.     :|...|:    |:.....|...|.
  Rat   169 WSSGFTALQASIDAAIIQLKTNVSLWRELESTKAVIMGEAAVVEIDTFPR--------------- 218

  Fly    67 GIMIIVIIIFFVVVS--LTKSIVEEKELQLKVTLNLMGVGSCLQWVAW-YIQTFIIFLIGSSIIT 128
            |:::|.::|.|....  |...||.|||.:||..|.:||:.....|::| .:.|.:|||     ::
  Rat   219 GVILIYLVIAFSPFGYFLAIHIVAEKEKRLKEFLKIMGLHDTAFWLSWVLLYTSLIFL-----MS 278

  Fly   129 LFWKLVLPNSEISFMPFTHWSMALFVLLVL-SHCTICFSFLMSSLISTTYRISLVT-FLALIATY 191
            |...::...|  |..|.:. |:.:|:|..| ...::.|:.:::.|...:..:.:|. |:.::..:
  Rat   279 LLMAVIATAS--SLFPQSS-SIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGF 340

  Fly   192 LPFLILHSKGCSEGLNVFLS-----LFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLS 251
            :..||:..:.....|....|     .||:...||:.:     ||:.||..:.:|.|..:|
  Rat   341 VGLLIVLVESFPRSLVWLFSPLCQCAFLIGIAQVMHL-----EDFNEGALFSSLTEGPYP----- 395

  Fly   252 VGYILLVMILASFLSLLLCLYLEKIRPGPYGV---------PQPWHFPCTRCCSTESLLPYSRLF 307
            :...|.::.|.|....||.:||:::.||.:|:         |..|         :::...|..|.
  Rat   396 LIITLTMLALDSVFYALLAVYLDQVIPGEFGLRRSSLYFLKPSYW---------SKNKRNYKELS 451

  Fly   308 -NRIFGIYSAAPDEERPDLQLIEPDPVDKIA--GVQIRGLSKTFGK----MEVVKNVSFDMFEGQ 365
             ..|.|..|..        :::||...:.|.  .::|.|:.|.:.|    :|.::|:|||::|||
  Rat   452 EGNINGNISLN--------EIVEPVSSEFIGKEAIRISGIQKAYRKKNETVEALRNLSFDIYEGQ 508

  Fly   366 ITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQ--ERRQAQRCIGLCPQQNVLFKHLSS 428
            ||.|:||:|.||:||:::|.|...|:.|.|.|.|..:.:  |..:|::.||:|||.::.|..|:.
  Rat   509 ITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQSDMNFDVLTV 573

  Fly   429 VSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLIC 493
            ..::.:.:.::|:....:..|||..|..|::|..|...|:.||||.:|:||:..::.|..|:|:.
  Rat   574 EENLSILASVKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLL 638

  Fly   494 DEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQ 558
            |||:.|:||.:|..:|.|:...|.....:.:||.:|:.::|.||..:||.|.|:|:||..|||.:
  Rat   639 DEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSK 703

  Fly   559 VDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMN 623
            ......::....:.|..|.|:||:.:|:..........:.:.|.||......||.||..|:...|
  Rat   704 WGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQIVYSLPFKDMDKFSGLFSALDIHSN 768

  Fly   624 ILGVRGFSLSSVSLEEIFMSFGAE------DLNSRQSGGAEKRDDDDRDDDEENEV-----QDGN 677
             |||..:.:|..:||::|:....|      |.:.......|:..|....|:.|..:     ...:
  Rat   769 -LGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKAS 832

  Fly   678 VRSCKKQWRAMM--------------TKKVMALYDNKVYFLLLL--------------------- 707
            :.|....|:..:              :|.|     ..|..|||:
  Rat   833 LVSTMSLWKQQVSTIAKFHFLSLKRESKSV-----RSVLLLLLIFFAVQIFMFLVHHSFKNAVVP 892

  Fly   708 --LTPIVYYITTLMMATKPHH-------SGRPTFNISDYGVDKFT---ILLSVPVSKSYTEERRA 760
              |.|.:|:   |....|||.       ......:|:|. :|.||   |::::.....|..  .|
  Rat   893 IKLVPDLYF---LKPGDKPHKYKTSLLLQNSTDSDINDL-IDFFTQQNIIVAMFNDSDYVS--AA 951

  Fly   761 DSIASLIKGKLKLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAA 825
            ...|:|      .:|.||  ||||              |.::...|              .|::.
  Rat   952 PHSAAL------NVVQSE--KDYV--------------FTAVFNST--------------MVYSL 980

  Fly   826 PMILNLVYNALAQELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIY----VIGYVSIAMIIFS 886
            |:::|::.|.....| ....:|::.|.|| :::..|.:..    :.:|    ::|.:..||..:.
  Rat   981 PVMMNIISNYYLYHL-NVTDTIQIWSTPF-IQEITDIVFK----VELYFQAALLGIIVTAMPPYF 1039

  Fly   887 SAVIQERVSHMKMLQ----EVSGLEMITYWLSHLAFDMVVFFILVLALLLPLYGYAPWYLLLCVL 947
            :   .|...:.|:..    ::|||....||:.....|:.:||:::..:|..|:.:...      |
  Rat  1040 A---MENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFVVLTLMLGSLFAFHHG------L 1095

  Fly   948 FFTGLAGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMILGA---LALIFKMVYVAIYVANMH 1009
            :|..:..|..::.||:.:.      |:||.:.|.......||..   .:.|:.:..:|.......
  Rat  1096 YFYPVKFLAVVFCLIAYVP------SVILFTYIASFTFKKILNTKEFWSFIYSVTALACVAVTEI 1154

  Fly  1010 PLIAGYNCIQKCFHY--------MSLCGSYISEAQN-----PLSENLTSDEMYCINPLAFLEPRC 1061
            ....||. :...|||        ..|.|..||..:.     |.:||
  Rat  1155 TFFLGYG-VTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNIPKTEN------------------- 1199

  Fly  1062 VCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCV-W------YRCK------------------- 1100
             ..||  |..:||    |:|:       .|..|| |      |..|
  Rat  1200 -AYNP--WDRLLV----AVIM-------PYLQCVLWIFLLQHYEKKHGGRSIRKDPLFRALSQKA 1250

  Fly  1101 --GCCPYSSKGSIEDPKVSREAEKIRAMDADQIGTR--ALVVNGVSKKYG----------CDQLA 1151
              ...|.......||..|..|..|::.:...|....  |::|..:.|:|.          ..::|
  Rat  1251 KHKKFPEPPINEDEDEDVKAERLKVKELMGCQCCEEKPAIMVYNLHKEYDDKKDFLHSRKTTKVA 1315

  Fly  1152 VNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGY-SMRMKRNKAMKELGYCP 1215
            ...:||.:|....:||||||||||:|...::||:.....|.|::..| |...:.:::.|.:||||
  Rat  1316 TKYVSFCVKKGEILGLLGPNGAGKSTIINILVGDVEPTSGKIFLGDYGSHSNEDDESTKCMGYCP 1380

  Fly  1216 QSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAV 1280
            |::..:..:|.::..:::..:.|..|.|:.:...::......::||.|.:.....|.|||:..|:
  Rat  1381 QTNPLWPDITLQEHFEIYGAVKGMSSGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFAL 1445

  Fly  1281 A-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGK-AVLLTSHNMDEINALCSKSVILVDGS 1343
            : .|...:..|||||.|:||.:::|:|..|....:..| |.|||:|.|:|..|:|.:..|:|.|.
  Rat  1446 SMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVCDRVAIMVSGQ 1510

  Fly  1344 IYAMGSVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI 1408
            :..:|:|||:|:|..||..|::.:....:|:  .:.:::.:|...:|||..:|  .||..|.::|
  Rat  1511 LRCIGTVQHLKSKFGKGYFLEIKLKDWIENL--EIDRLQREIQYIFPNASRQE--SFSSILAYKI 1571

  Fly  1409 SKD--TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKSN 1457
            .|:  .|.|:.|..:|..:.::.:|:||.||.:||..|.|:.:|:.::.::
  Rat  1572 PKEDVQSLSQSFAKLEEAKHTFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	106/314 (34%)
		ABC_subfamily_A	339..556	CDD:213230	81/222 (36%)
		ABC2_membrane_3	<821..1018	CDD:289468	41/207 (20%)
		CcmA	1135..1450	CDD:224054	101/329 (31%)
		ABC_subfamily_A	1136..1354	CDD:213230	71/230 (31%)
Abca5	NP_775429.1	ABC2_membrane_3	<214..416	CDD:289468	54/234 (23%)
		CcmA	476..788	CDD:224054	105/312 (34%)
		ABC_subfamily_A	478..701	CDD:213230	81/222 (36%)
		ABC2_membrane_3	<957..1224	CDD:289468	72/357 (20%)
		CcmA	1288..1615	CDD:224054	101/330 (31%)
		ABC_subfamily_A	1290..1521	CDD:213230	71/230 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720