DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca8b

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_038879.2	Gene:	Abca8b / 27404	MGIID:	1351668	Length:	1620	Species:	Mus musculus

Alignment Length:	1606	Identity:	397/1606 - (24%)
Similarity:	687/1606 - (42%)	Gaps:	326/1606 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DGSYP--------LYKTGFLAVQQALSQVHIK----HK-CKEFNKTQGDIKFPPIKDLPSPPIFK 56
            ||.|.        .:|.||:|:|.|::...|:    |. .:|.....|  ||..|.     |..:
Mouse   158 DGLYEDVNCLIAIFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSG--KFMKIH-----PFVR 215

  Fly    57 SDNSSTLQDVGIMIIVIIIFFVVVSLTKSI-VEEKELQLKVTLNLMGVGSCLQWVAW-YIQTFII 119
            .:...|    ...|...||.|..::...|| |..:..::|..:.:||:.....|::| .:....:
Mouse   216 QEGILT----DFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAGFV 276

  Fly   120 FLIGSSIITLFWKLVLPNSEISFMPFTHWSM--ALFVLLVLSHCTICFSFLMSSLISTTYRISLV 182
            |::..|       |.|....:.|...|.:.:  :||:|..||..|:  :||||:|:..:....|.
Mouse   277 FIMALS-------LALVIKSVQFFILTSFMVVFSLFLLYGLSMITL--AFLMSALVRKSVLTGLS 332

  Fly   183 TFLALI----------ATYLPFLILHSKGCSEGLNVFLSL-FLLSGLQVLVVGICMWEDYGEGLQ 236
            .||..|          ..|||..:..:      |::|... |.|...|:|.|      ||
Mouse   333 VFLLTIFWGSLGFTSLYRYLPAPVEWT------LSLFSPFAFTLGMAQLLRV------DY----- 380

  Fly   237 WGNLFETSWPGGTLSVGYIL---LVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTE 298
              :|...:.|........|:   .:::..:||.|.|.:|.||:.|..||   ..|.|
Mouse   381 --DLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYG---HQHSP-------- 432

  Fly   299 SLLPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKI-----------------AGVQIRGLSK 346
                       :|.:.|:...:.|....:|..|.:|.:                 ..::||.:||
Mouse   433 -----------LFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSFEPVSPEFHGKESIRIRNISK 486

  Fly   347 TF----GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALI--NGFDIRQE 405
            .:    .|:|.:|:::.|::|||||.::||:||||:||:::|:|...||.|:..|  |......:
Mouse   487 EYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMAD 551

  Fly   406 RRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNL 470
            .....|..|:|||.||.|..|:...:::||:::||:...:|:.|||..|.:|.::..:.:.|:||
Mouse   552 LENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEVQRVLLELEMKNIQNILAQNL 616

  Fly   471 SGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLG 535
            |||.:|:|:...::.|..::.:.|||:.||||.:|..:|.|:.|.:....:|.:|..:|:.::|.
Mouse   617 SGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILA 681

  Fly   536 DRVVIISDGQLRCIGSLPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGR-DV 599
            ||.|.||:|:|:|.||..||||:......::.:.::.|..|.:|||:.:|:...: .|.:|. .:
Mouse   682 DRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAK-LSAEGEGKL 745

  Fly   600 CYKLPLSKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFM------SFGAEDLNSRQSGGAE 658
            .|.|||..:..|..|.:.|:|... ||:..:.:|..:|.|:|:      |....:::....|..|
Mouse   746 LYTLPLETTYRFPELCQSLDSCPG-LGIENYGVSMTTLNEVFLKLEGKASIDEPEVDIVGEGQTE 809

  Fly   659 KRDDDDRDDDEENEVQDGNVRSCKKQ-----WR----AMMTKKVMALYDNKVYFLLLLLTPIVYY 714
            :..|.:|..:.|..:  .::|..:|.     ||    |:...:::.|...:...|.:||..:|..
Mouse   810 RSGDTERLMEMEQTL--SSLRETEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLILVVGI 872

  Fly   715 ITTLM--MATKPHHSGRPTFNIS--DYGV-------DKFTILLSVPVSKSYTEERRADSIASLIK 768
            ...|.  ::||...|.. |:.:|  ||.:       ...|.||.:    :.||....|.|.|:.:
Mouse   873 CPFLFENISTKIRQSSY-TWELSPHDYFLAPGQQPQGMLTQLLII----NKTEASIDDFIHSVER 932

  Fly   769 GKLKLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVY 833
            ..:.|.|.:...:|..||  .|..|       ::.:...::.....:......::..|::::::.
Mouse   933 QNIALEVDASGTRDGTDD--PSYNG-------ALIVSGNEKNHSFSFACNTKRLNCFPVLMDILS 988

  Fly   834 NALAQELIGPKISIEVTSVPF----TLRKKED-----FLISNNGDIPIYVIGYVSIAMIIFSSAV 889
            |.|. .::.|...|:.....:    |:...||     |.:......|.|      |||   ||..
Mouse   989 NGLL-GMVKPSARIQTDRSTYLMDETIHPLEDLWKTAFWLILTSACPPY------IAM---SSVT 1043

  Fly   890 IQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFILVLALLLPLY------------------- 935
            ..:..:..::  .||||....||:.....|:.::..:.|.:.|..|
Mouse  1044 DYKNRAWFQL--RVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQIP 1106

  Fly   936 ---GYAPWYLLLCVLFFTGLAGLIFIYFLISMLS------ATFLAVSMILLSVIIGSLILMILGA 991
               |||              ..|||:.::||.:|      :...::|..:::|...::||
Mouse  1107 CSVGYA--------------ISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVIL----- 1152

  Fly   992 LALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINP-LA 1055
              |.|.:.....|:..:.|......|:....|.  ..|....|.|             .|.| |.
Mouse  1153 --LAFDVDGTQYYIIFLIPPSTLVGCLILSLHL--FIGQIFEEGQ-------------VIEPFLV 1200

  Fly  1056 FLEPRCVCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCVW------------YRCKGCCP---- 1104
            ||.|                     .|.:.|..|......|            :|..   |
Mouse  1201 FLIP---------------------FLHVFIFIFTLRCLEWKFGKKTMRKDPIFRIS---PRNND 1241

  Fly  1105 -YSSKGSIEDPKVSREAEKIRAMDADQIGTR-----ALVVNGVSKKYGCDQ----------LAVN 1153
             |.:....||.....:.|::|..:| .:.|.     .::.:.:.|:|...|          :|..
Mouse  1242 VYQNPEEPEDEDEDVQMERMRTANA-LVSTSFDEKPVIIASCLRKEYAGKQKHCLSKKKAKIATR 1305

  Fly  1154 NISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSD 1218
            |:||.::....:||||.|||||:|:.|||.|:..:..|.:.:.|    .:.......||||||.:
Mouse  1306 NVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKG----SREGDTPGFLGYCPQEN 1366

  Fly  1219 SFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-C 1282
            :.:..||.::.|::|..:.|...........:|||....:..|...:...|.|.|||:...:: .
Mouse  1367 ALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKLCFVLSIL 1431

  Fly  1283 GANSLICLDEPSAGVDPASRRHVWTIINEVAQQ-GKAVLLTSHNMDEINALCSKSVILVDGSIYA 1346
            |..|::.|||||.|:||..::.:|..|..:.:. .:..|||:|.|.|..|||.:..|||.|.:..
Mouse  1432 GNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAILVSGRLRC 1496

  Fly  1347 MGSVQHVKNKIAKG----MTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQ 1407
            :||:||:|:|..|.    |.:|.:..|:|         :..:|...:|.|..:|:|  |..:.::
Mouse  1497 IGSIQHLKSKFGKDYLLEMKVKTLEQVEP---------LNTEILRLFPQASRQERY--SSLMAYK 1550

  Fly  1408 ISKDT--SWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            :..:.  ..|:.|..:|..:.::.||:|||||.:||..|.|:::|:
Mouse  1551 LPVEAVQPLSQAFFKLEKVKQTFDLEEYSLSQSTLEQVFLELSKEQ 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	107/336 (32%)
		ABC_subfamily_A	339..556	CDD:213230	82/222 (37%)
		ABC2_membrane_3	<821..1018	CDD:289468	43/233 (18%)
		CcmA	1135..1450	CDD:224054	99/332 (30%)
		ABC_subfamily_A	1136..1354	CDD:213230	72/229 (31%)
Abca8b	NP_038879.2	rim_protein	<265..1596	CDD:130324	368/1486 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720