Protein Alignment CG42816 and Abca7

DIOPT Version :10

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_001334010.1
• Gene: Abca7 / 27403
• MGIID: 1351646
• Length: 2167
• Species: Mus musculus
• Alignment Length: 1761
• Identity: 449/1761 - (25%)
• Similarity: 758/1761 - (43%)
• Gaps: 427/1761 - (24%)

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIIIFFV 78
            ||:.:|..|.|..::......::|...::..|      .|.:..|....:....:.:.:.:.:..
Mouse   499 GFVYLQDLLEQAAVRVLGGGNSRTGLYLQQMP------HPCYVDDVFLRVLSRSLPLFLTLAWIY 557

  Fly    79 VVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSEISF 142
            .|:|| |::|.|||.:|:.|:..||:...:.|:.|::.....||:.::::.|..||.      :.
Mouse   558 SVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLG------NI 616

  Fly   143 MPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLI-------LHSK 200
            :|::|..:....|...:..|:..|||:|:..|.....:....||..|.|||:::       ||..
Mouse   617 LPYSHPVVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLG 681

  Fly   201 GCSEGLNVFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGT------LSVG 253
            |       .|:..|||      |.:    .:.:.|:.|:|.||.||       ||      .|:.
Mouse   682 G-------LLAASLLSPVAFGFGCE----SLALLEEQGDGAQWHNL-------GTGPAEDVFSLA 728

  Fly   254 YILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIYSAAP 318
            .:...::|.:.:..|...|||.:.||.||:|:||:||..|........|.|.:.         ||
Mouse   729 QVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVL---------AP 784

  Fly   319 DEERPDLQLIEPDPVDKIAGVQIRGLSKTFG--KMEVVKNVSFDMFEGQITVLMGHNGAGKTTLI 381
            ..:.|.: |:|..|:..:.||.||||.|.|.  ....::.::.|.:||.||..:|||||||||.:
Mouse   785 APQDPKV-LVEEPPLGLVPGVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTL 848

  Fly   382 SMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEV 446
            |:|:|...|:||:|.|.|.|::......:..:|:|||.||||..|:...|:..:.||:|:..|.:
Mouse   849 SILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAM 913

  Fly   447 KSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRL 511
            ..|.:..::.:.|..|:....|:||||.||:||||.:..||.:|:|.|||:.|:||::||.:|.|
Mouse   914 GPERERLIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWEL 978

  Fly   512 ILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV----------DASCLIT 566
            :|:.:||.|::|:||.||:.|:|||||.:::.|.|.|.||..||::.:          .:..|:|
Mouse   979 LLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVT 1043

  Fly   567 CEAR---------KRCD--------------------------------LEKLTSLISRHVGTIQ 590
            .:|:         |:.|                                ..::..|:.:||...|
Mouse  1044 HDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQ 1108

  Fly   591 PFSIKGRDVCYKLPLSKS--KYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQ 653
            .......::...||.:.:  ..|:.:|::|:.|:.:||:.|:.:|..:|||||:.. .||  :.:
Mouse  1109 LVEDLPHELLLVLPYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKV-VED--AHR 1170

  Fly   654 SGGAEKRDDDDRDD-------------DEENEVQDGNVR------------------------SC 681
            .||      |.|..             .|.:.:::|.:.                        :|
Mouse  1171 EGG------DSRPQLHLRTCTPQPPTGPEASVLENGELAKLVLDPQAPQGLAPNAAQVQGWTLTC 1229

  Fly   682 KKQWRAMMTKKVM----------------ALYDNKVYFLLLLLTPIVYY---------------- 714
             :|.||::.|:.:                ||:.....|..|::.|...|
Mouse  1230 -QQLRALLHKRFLLARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSF 1293

  Fly   715 --------------ITTLM---------MATKPHHSGRPTFNISDYGVDKFTI------LLSVPV 750
                          :..|:         |..|.......|.:::.|    ||:      :.|:..
Mouse  1294 FSEDAPGDPNRMKLLEALLGEAGLQEPSMQDKDARGSECTHSLACY----FTVPEVPPDVASILA 1354

  Fly   751 SKSYTEE-------------RR--------------ADSIASLIKGKLKLIVVSEQIKDYV---- 784
            |.::|.|             ||              ..::|.|  |::...:....:.|::
Mouse  1355 SGNWTPESPSPACQCSQPGARRLLPDCPAGAGGPPPPQAVAGL--GEVVQNLTGRNVSDFLVKTY 1417

  Fly   785 ---------DDKWK--------SREGR--------------REI-----------------NFVS 801
                     ..||.        |..||              .||                 |...
Mouse  1418 PSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQ 1482

  Fly   802 MAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELI--GP---KISIEVTSVPFTLRKK-- 859
            .|:....|..|..|...:.: ||....:|...|.|...|:  ||   ..||...:.|..|.|:
Mouse  1483 WALGLDARNSLKIWFNNKGW-HAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQL 1546

  Fly   860 -EDFLISNNGD--IPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM- 920
             |..||:::.|  :.|.|:..:|.....|:..:|:||::..|.||.||||....|||.:..:||
Mouse  1547 SEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMC 1611

  Fly   921 --------VVFFIL--------------VLALLLPLYGYAPWYLLLCVLFFTGLAGLIFIYFLIS 963
                    |||..|              .|.|||.|||::...|:....||..:....::.....
Mouse  1612 NYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCI 1676

  Fly   964 MLSATFLAVSMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLC 1028
            .|   |:.::..:.:.::..|....|..::.|.|.|:          ||..:.|:.:     .|.
Mouse  1677 NL---FIGINSSMATFVLELLSDQNLQEVSRILKQVF----------LIFPHFCLGR-----GLI 1723

  Fly  1029 GSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTW----PDMLVMLGTAIILFLLIMFF 1089
            ....::|.....|.| .|:.:              .:|:.|    .::|.|:....:..|:.:..
Mouse  1724 DMVRNQAMADAFERL-GDKQF--------------QSPLRWDIIGKNLLAMMAQGPLFLLITLLL 1773

  Fly  1090 EYGSCVWYRCKGCCPYSSKGSI-----EDPKVSREAEKIR--AMDADQIGTRALVVNGVSKKY-G 1146
            ::.:.:       .|.|....:     ||..|::|.|::.  |...|     .||:..::|.| |
Mouse  1774 QHRNRL-------LPQSKPRLLPPLGEEDEDVAQERERVTKGATQGD-----VLVLRDLTKVYRG 1826

  Fly  1147 CDQLAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKEL 1211
            ....||:.:...:.|..|.||||.||||||:||:|:.|:.....|...::|:::..:|:.|.:.:
Mouse  1827 QRNPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSM 1891

  Fly  1212 GYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKI 1276
            |||||||:.|:.||||:.|::|..:.|.|...:.:.......:.|...:.|:....||||.|||:
Mouse  1892 GYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKL 1956

  Fly  1277 NAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILV 1340
            ..|:| .|..:::.||||:.|:||::||.:|..:..|.::|::|:||||:|:|..|||::..|:|
Mouse  1957 ATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMV 2021

  Fly  1341 DGSIYAMGSVQHVKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRL 1404
            :|....:||.||:|.:...|.||.| |...||:..:|.       |.:|:|.|||:|.:  ..||
Mouse  2022 NGRFRCLGSSQHLKGRFGAGHTLTLRVPPDQPEPAIAF-------IRITFPGAELREVH--GSRL 2077

  Fly  1405 TFQISKD--TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAF---------------EEIAEERR 1452
            .||:...  .:.:.:|..:.....:..:||:|:||.:||:.|               :|..||..
Mouse  2078 RFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQEAEEEEV 2142

  Fly  1453 KKKSNQ 1458
            .|...|
Mouse  2143 SKPGRQ 2148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	436/1685 (26%)
Abca7	NP_001334010.1	rim_protein	1..2128	CDD:130324	444/1739 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1088		4/45 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1172..1192		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2126..2167		5/23 (22%)