DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42816 and ABCA6

DIOPT Version :10

Sequence 1:NP_730301.3 Gene:CG42816 / 39977 FlyBaseID:FBgn0261998 Length:1459 Species:Drosophila melanogaster
Sequence 2:NP_525023.2 Gene:ABCA6 / 23460 HGNCID:36 Length:1617 Species:Homo sapiens


Alignment Length:1597 Identity:407/1597 - (25%)
Similarity:703/1597 - (44%) Gaps:330/1597 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 YKTGFLAVQQALS----QVHIKHKCKE--FNKTQGDIKFPPI--KDLPSPPIFKSDNSSTLQDVG 67
            :..||:|:|.|::    ::...|...|  .:.|...:|..|.  |:|....:|            
Human   171 WNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMF------------ 223

  Fly    68 IMIIVI----IIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAW------YIQTFIIFLI 122
            |:..::    :::|:.:::||...:.|.|     :.:||:.....|::|      :|  |||.:.
Human   224 ILFFLLHFSPLVYFISLNVTKERKKSKNL-----MKMMGLQDSAFWLSWGLIYAGFI--FIISIF 281

  Fly   123 GSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTF-LA 186
            .:.|||....:|:....:.|:.|..:.::|..|:          ||||.|:......:||.| |.
Human   282 VTIIITFTQIIVMTGFMVIFILFFLYGLSLVALV----------FLMSVLLKKAVLTNLVVFLLT 336

  Fly   187 LIATYLPFLILHSKGCSEGLNVFLSL-----FLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWP 246
            |....|.|.:.:.: ....|...|::     |....:|::.:      ||       ||....:|
Human   337 LFWGCLGFTVFYEQ-LPSSLEWILNICSPFAFTTGMIQIIKL------DY-------NLNGVIFP 387

  Fly   247 ---GGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFN 308
               |.:.::.....:::|...:.|||.||.:||.  |||..:  |:......::.|...:.|...
Human   388 DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKIL--PYGDER--HYSPLFFLNSSSCFQHQRTNA 448

  Fly   309 RIFGIYSAAPDEERPDLQLIEPDPVDKIA-------GVQIRGLSKTF----GKMEVVKNVSFDMF 362
            ::.   ....|.|.|.....||     :|       .::||.:.|.:    ||:|.:|.:.||::
Human   449 KVI---EKEIDAEHPSDDYFEP-----VAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIY 505

  Fly   363 EGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDI--RQERRQAQRCIGLCPQQNVLFKH 425
            |||||.::||:||||::|:::|.|...||.|:..|...::  .|:..:.::..|:|||.||.|..
Human   506 EGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDI 570

  Fly   426 LSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKV 490
            |:...::.||::::|:...||:.|||..|.:|::|..:...|::||.|.:|:|:...::.|..::
Human   571 LTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQI 635

  Fly   491 LICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFL 555
            |:.|||:|||||.:|.::|.|:.|.:....||.:|..:|:.::|.||.||:|:|:|:|.||..||
Human   636 LLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFL 700

  Fly   556 KKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLES 620
            |::......::....:.|:.|::||.|:.|:...:..:.....:.|.|||.::..|..||.||: 
Human   701 KRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLD- 764

  Fly   621 QMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDDDEENEVQDGNVRSCKKQ- 684
            :.:..||.|:.:|..:|.|:||....:....:.....|.    .||.:..||::..:....:.| 
Human   765 KCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEM----IRDSESLNEMELAHSSFSEMQT 825

  Fly   685 -------WR----AMMTKKVMAL-YDNKVYFLLLL-----LTPIV-------------------- 712
                   ||    ||...:.:.| ...||...|||     :.|::                    
Human   826 AVSDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNE 890

  Fly   713 -YYITTLMMATKPHHSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVV 776
             |:::...:..:|.                 |.||.:    :.||....|.|.||....:.|.| 
Human   891 LYFLSPGQLPQEPR-----------------TSLLII----NNTESNIEDFIKSLKHQNILLEV- 933

  Fly   777 SEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHY----------VHAAPMILNL 831
                     |.:::|.|...:::....|.:|.:         :.|          :|..|:::|:
Human   934 ---------DDFENRNGTDGLSYNGAIIVSGKQ---------KDYRFSVVCNTKRLHCFPILMNI 980

  Fly   832 VYNALAQELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSH 896
            :.|.|.| :......|.:.|.||.|.....:....:|...:::: ..||:..| :...|.:...:
Human   981 ISNGLLQ-MFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFLFLV-LCSISPYI-TMGSISDYKKN 1042

  Fly   897 MKMLQEVSGLEMITYWLSHLAFDMVVFFILVLALL-LPLYGYAPWYLLL-------CVLFFTG-L 952
            .|....:|||....||......| |.||||:|.|: |..|.....|||:       .|:...| .
Human  1043 AKSQLWISGLYTSAYWCGQALVD-VSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYA 1106

  Fly   953 AGLIFIYFLISML-----------SATFLAVSMILLSV-IIGSLILMILGALALIFKMVYVAIYV 1005
            |.|:|..::||.:           |..|...|.|:.|: :|....|.|     ||..||.|..|.
Human  1107 ASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSI-----LITTMVLVPSYT 1166

  Fly  1006 ANMHPLIAGYNCIQKCF-------HYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVC 1063
                  :.|:    |.|       ||..     ..||...||   .:|.:.|..|          
Human  1167 ------LLGF----KTFLEVRDQEHYRE-----FPEANFELS---ATDFLVCFIP---------- 1203

  Fly  1064 VNPMTWPDMLVMLGTAIILFLLIMFFEYGSCVWYRCKGCCPYSSKGSIEDP-----KVSREA--- 1120
                       ...|.:.:|:|       .|:..:|      ..|...:||     ..||:|   
Human  1204 -----------YFQTLLFVFVL-------RCMELKC------GKKRMRKDPVFRISPQSRDAKPN 1244

  Fly  1121 -------------EKIR---AMDADQIGTRALVVNG------VSKKYGC-----DQLAVNNISFA 1158
                         |:||   |:....:..:.:::..      ..:|..|     .::|..||||.
Human  1245 PEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFC 1309

  Fly  1159 LKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEF 1223
            ::....:||||||||||:::.:||.|......|.:.:.|.|      ..:..||||||.:..:..
Human  1310 VQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCS------SVLGHLGYCPQENVLWPM 1368

  Fly  1224 LTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVACGANS-L 1287
            ||.|:.|:|:..:.|....|......:|...|...:.|:..:...:.|..||:...::...|| :
Human  1369 LTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPV 1433

  Fly  1288 ICLDEPSAGVDPASRRHVWTIINEVAQQ-GKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQ 1351
            :.|||||.|:||..::.:|..|..|.:. .:.||||:||:.|..|||.:..|:|.|.:..:||:|
Human  1434 LLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQ 1498

  Fly  1352 HVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKDTSW-- 1414
            |:|||:.|...|:|.|     ...:.:|.:..:|...:|.|..:|:|  |..||:::.....:  
Human  1499 HLKNKLGKDYILELKV-----KETSQVTLVHTEILKLFPQAAGQERY--SSLLTYKLPVADVYPL 1556

  Fly  1415 SEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            |:.|..:|..:.:::||:|||||.:||..|.|:::|:
Human  1557 SQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQ 1593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42816NP_730301.3 rim_protein <81..1451 CDD:130324 391/1513 (26%)
ABCA6NP_525023.2 rim_protein <174..1593 CDD:130324 406/1592 (26%)

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