DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca8a

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_006533124.3	Gene:	Abca8a / 217258	MGIID:	2386846	Length:	1653	Species:	Mus musculus

Alignment Length:	1622	Identity:	402/1622 - (24%)
Similarity:	693/1622 - (42%)	Gaps:	369/1622 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GSYPLYKTGFLAVQQALS----QVHIKHKCKE--FNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQ 64
            |....::.||:|:|.|::    :|...|...|  .:.|...||...         |.....:|..
Mouse   202 GLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKYIKIDS---------FVGQEGTTTD 257

  Fly    65 DVGIMIIVIIIFFVVVS-------LTKSIVEEKELQLKVTLNLMGVGSCLQWVAW---Y-IQTFI 118
                    ..:||.::.       ::..:..|:: ::|..:.:||:.....|::|   | :..|:
Mouse   258 --------CFLFFCIIRFSPLTYYISAGVTRERK-KMKGLMAVMGLRDSAFWLSWGLLYGVIVFV 313

  Fly   119 IFLIGSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVT 183
            :.|:.::|:.|...:.|....:.|..|..:.::|          |..|||||.|:..::...||.
Mouse   314 VTLLSTTIVKLVQFVFLTGFMVIFSLFFFYGLSL----------ISLSFLMSVLLKKSFLTDLVV 368

  Fly   184 FLALIA----------TYLPFLILHSKGCSEGLNVFLSL-----FLLSGLQVLVVGICMWEDY-- 231
            ||..::          .|||.          .|...|||     |:|..:|:|.:      ||
Mouse   369 FLLTVSCGSLGFTALYRYLPV----------SLEWLLSLLSPFAFMLGMVQLLRL------DYDV 417

  Fly   232 -GEGLQWGNLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHF------ 289
             ......||..|.        :|.|.::.....|. |||..|.||:.|..||...|..|
Mouse   418 NSNADPMGNPNEV--------IGTIFMLFFDGVFY-LLLTFYFEKVLPSEYGRRHPPLFFLKSSF 473

  Fly   290 -----PCTRCC---------STESLLPYSRLFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQ 340
                 |..|..         |.:|..|.|..|:          .:|                .::
Mouse   474 WSGQNPANRTALDNETDYEFSDDSFEPVSMEFH----------GKE----------------AIR 512

  Fly   341 IRGLSKTF----GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFD 401
            ||.|:|.:    .:.|.:|:::.|:::||||.::||:||||:||:::|:|...||.|...|:...
Mouse   513 IRNLTKDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNK 577

  Fly   402 IRQ--ERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKR 464
            :.:  :.....:..|:|||.||.|..|:...:::||::::|::..||.:|||..|.:|:::..:.
Mouse   578 LSEMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQN 642

  Fly   465 LAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLD 529
            :..:|||||.:|:|:...::.|..::.:.|||:.||||.:|..:|..:.|.:....:|.:|..:|
Mouse   643 ILVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMD 707

  Fly   530 DGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSI 594
            :.::|.||.|.||.|:|:|.||..||||:......::.:..:.|..|::|||:.:|:...:..:.
Mouse   708 EADILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAE 772

  Fly   595 KGRDVCYKLPLSKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFM------SFGAEDLNSR- 652
            ....:.|.|||.::..|..|:||||...: ||:..:.:|..:|.|:|:      |....|:...
Mouse   773 SEGKLSYILPLERTNKFPDLYRDLERSPD-LGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTE 836

  Fly   653 --QSGGAEKRDDDDRDDDEENEVQDGNVRSCKKQWRAMMTKKVMAL---------YDNKVYFLLL 706
              |:|||.   ..:|..:.|..|...|.|...|...|:..:::.|:         ::.|...:|:
Mouse   837 DVQAGGAR---SPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHERKSIVILI 898

  Fly   707 L--------------------------LTPIVYYITTLMMATKPHHSGRPTFNISDYGVDKFTIL 745
            |                          |.|.:|::|       |....:|          ..|.|
Mouse   899 LVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLT-------PGQQPQP----------PLTNL 946

  Fly   746 LSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRT 810
            |.|    :.|..:..|.|.||.:..:.|.|          |.:.:|.|..:..:....|.:||.
Mouse   947 LIV----NKTGAKIDDFIHSLEQQNIALEV----------DAFGTRNGTEDSQYNGAIILSGDE- 996

  Fly   811 GLIGWVGPRHY----------VHAAPMILNLVYNALAQELIGPKISIEVTSVPF---TLRKKEDF 862
                    ::|          ::..|:::::|.|.|. .|..|...|:.....|   ...:|.|:
Mouse   997 --------KNYNFTLACNTKRLNCFPVLVDIVSNGLL-GLFAPSAHIQTDRSTFPEENDHRKFDY 1052

  Fly   863 LISNNGDIPIYVIGYVSIAMII---FSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFF 924
            |        .|...:|.:...:   .|...|.:..:..:....:|||....||.....|::.|:.
Mouse  1053 L--------AYFFLWVLLMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVYC 1109

  Fly   925 ILVLALLLPLYGYAP-------WYLLLCVLFFTGLA-GLIFIYFLISML-----------SATFL 970
            .|:|::.:..|..||       ..|.:.:|:..|.| .:||:.::||.:           |..|.
Mouse  1110 ALILSIFIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFY 1174

  Fly   971 AVSMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEA 1035
            .||..       |:..|::.    .|:.:.:.:.:|.:.|...|              |..:...
Mouse  1175 IVSFF-------SMCFMLID----YFRDISLFVLIALVPPATLG--------------GCTLLHF 1214

  Fly  1036 QN-PLSENLTSDEMYCINPLAFLEPRCVCVNPMTWPDMLVMLGTAI-ILFLLIMFFEYGSCVW-- 1096
            :| ..||.:...|.. .:.|.||.|               :|..|| ::.|..|..::|....
Mouse  1215 ENREFSEIIFEPERE-YSYLFFLAP---------------LLHFAIFVVILRCMERKFGMKTMRT 1263

  Fly  1097 ---YRCKGCCPYSSK--GSIEDP-----KVSRE----AEKIRAMDADQIGTRALVVNGVSKKY-- 1145
               :|..   |.|.:  .:.|||     .||:|    |..:.:.|..:  ..|::.:.:.|:|
Mouse  1264 DPVFRIS---PRSDRVFNNPEDPDGEDEDVSQERVWTANALTSADFQE--KPAIIASCLRKEYKG 1323

  Fly  1146 --GC------DQLAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRM 1202
              .|      .::|..||||.::....|||||.|||||:|:.|||.||.....|.:.:.|.|
Mouse  1324 KKKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVLLKGSS--- 1385

  Fly  1203 KRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITY 1267
             .......||||||.::.:..||.|:.|::|..|.|....|.|...|:|||....:..|...:..
Mouse  1386 -TGDTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQDQLKSPVKT 1449

  Fly  1268 YSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEV-AQQGKAVLLTSHNMDEIN 1330
            .|.|.|||:...:: .|..|::.|||||.|:||..::.:|..|... :...:..|||:|.|.|..
Mouse  1450 LSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAE 1514

  Fly  1331 ALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVV----NVQPDNMVAMLTKIEDDIYMTYPN 1391
            |:|.:..|:|.|.:..:||:||:|:|..|...|::.|    .|:|         :..:|...:|.
Mouse  1515 AVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVKTPSQVEP---------LNTEIMRLFPQ 1570

  Fly  1392 AELKEKYEFSGRLTFQISKD--TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            |..:|:|  |..:.:::.::  ...|:.|..:|..:.|:.||:|||||.:||..|.|:::|:
Mouse  1571 AARQERY--SSLMVYKLPREDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	101/318 (32%)
		ABC_subfamily_A	339..556	CDD:213230	76/222 (34%)
		ABC2_membrane_3	<821..1018	CDD:289468	46/231 (20%)
		CcmA	1135..1450	CDD:224054	108/332 (33%)
		ABC_subfamily_A	1136..1354	CDD:213230	79/229 (34%)
Abca8a	XP_006533124.3	rim_protein	<258..1630	CDD:130324	387/1547 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820