DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42816 and ABCA3

DIOPT Version :9

Sequence 1:NP_730301.3 Gene:CG42816 / 39977 FlyBaseID:FBgn0261998 Length:1459 Species:Drosophila melanogaster
Sequence 2:NP_001080.2 Gene:ABCA3 / 21 HGNCID:33 Length:1704 Species:Homo sapiens


Alignment Length:1581 Identity:458/1581 - (28%)
Similarity:761/1581 - (48%) Gaps:224/1581 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 DGSYPLY-KTGFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGI 68
            ||..|.| :.||||||.|:.:..:::......:.........||..|.||.........:|....
Human   200 DGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLP 264

  Fly    69 MIIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIIT-LFWK 132
            :::::...:..:::.:::|:|||.:||..:.:||:.|.|.|.||::..|:..||.:|.:| ||..
Human   265 LLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCV 329

  Fly   133 LVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPF--- 194
            .|.||  ::.:..:..|:.|..||..:..||.|||::|:..|.....:.........||:|:   
Human   330 KVKPN--VAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFV 392

  Fly   195 ------LILHSKGCSEGL-NVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSV 252
                  :.|..|.||..| ||.:::    |.|:    |..:|..|.|:||.:|............
Human   393 APRYNWMTLSQKLCSCLLSNVAMAM----GAQL----IGKFEAKGMGIQWRDLLSPVNVDDDFCF 449

  Fly   253 GYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHF---PCTRCCSTESLLPYSRLFNRIFGIY 314
            |.:|.:::|.|.|..|:..|:|.:.||.:||||||:|   |...|....::              
Human   450 GQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAV-------------- 500

  Fly   315 SAAPDEERPD------LQLIEPDPVDKIAGVQIRGLSKTF--GKME--VVKNVSFDMFEGQITVL 369
             |..:||..|      .:..|.:|.|.:||::|:.|||.|  |..:  .|::::.:::|||||||
Human   501 -AGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVL 564

  Fly   370 MGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQL 434
            :|||||||||.:|||.|...||||.|.|:|::|.|:..|.::.:|||||.::||.:|:...|:..
Human   565 LGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYF 629

  Fly   435 FSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTG 499
            :::|:||...:...||:..|..:.|::|....:|.||||.:|:||:..:|..|.||||.|||::|
Human   630 YAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSG 694

  Fly   500 LDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCL 564
            :|..:||.:|.|:...|...||:||||.:|:.::||||:.|::.|:|:|.||..|||::..|...
Human   695 MDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYH 759

  Fly   565 ITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMNILGVRG 629
            :|......|:.|.::.|:..||......|..|.::.:.||...:..|..||..||.:...||:..
Human   760 MTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIAS 824

  Fly   630 FSLSSVSLEEIFMSFG-----AEDLNSRQSGGA----EKRDDD-----------DRDD------D 668
            |..|..::||:|:..|     :.|:.:.|....    |:|..|           |..|      :
Human   825 FGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIE 889

  Fly   669 EEN---EVQDGNVRSCKKQWRAMMTKKVMALYDNKVYFL-----LLLLTPIVYYITTLMMATKPH 725
            ||.   ::..|....|::.| ||..||  |.|..:.:.:     |:.||.:...:..:..:::..
Human   890 EERTAVKLNTGLALHCQQFW-AMFLKK--AAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELF 951

  Fly   726 HSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDYVD-DKWK 789
            ........:.:||  :..:..|||.:....::                  :||.:||.:. :..:
Human   952 DDPMLRLTLGEYG--RTVVPFSVPGTSQLGQQ------------------LSEHLKDALQAEGQE 996

  Fly   790 SRE------------------GRREINFVSMAI-DTGDRTGLIGWVGPRHYVHAAPMILNLVYNA 835
            .||                  |..|...|:.:. |.|:||.:......:.| |:....|.:|.|.
Human   997 PREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAY-HSPATALAVVDNL 1060

  Fly   836 LAQELIGPKISIEVTSVP----FTLRKKEDFLISNNG-DIPIYVIGYVSIAMIIFSSAVIQERVS 895
            |.:.|.||..||.|::.|    .....|:.|.....| ||.:.::..::.....||...:.||..
Human  1061 LFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAV 1125

  Fly   896 HMKMLQEVSGLEMITYWLSHLAFDMVVFFI---LVLA--------------------LLLPLYGY 937
            ..|.:|.|||:.:.::|||.|.:|::.|.|   |:|.                    |||.|||:
Human  1126 QAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGW 1190

  Fly   938 APWYLL-LCVLFFTGLAGLIFIYFLISMLS--ATFLAVSMILLSVIIGSLILMILGALALIFKMV 999
            |...|: |...||.|.|.......:.::||  ||||.|:::.:..:....:...|..:.|:....
Human  1191 AIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNH 1255

  Fly  1000 YVAIYVANMHPLIAGYNCIQKC------FHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLE 1058
            .:.:.|::.:   ..|...:.|      .||   |..|          |:...|    |..|:..
Human  1256 CLGMAVSSFY---ENYETRRYCTSSEVAAHY---CKKY----------NIQYQE----NFYAWSA 1300

  Fly  1059 P---RCVCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCVWYRCKG-CCPYSSKGSI-------- 1111
            |   |.|.        .:...|.|    .||:.|...:.:..|.:| .|....:.::        
Human  1301 PGVGRFVA--------SMAASGCA----YLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMP 1353

  Fly  1112 ---EDPKVSREAEKIRAMDADQIGTRALVVNGVSKKYGCDQ----LAVNNISFALKPSHCVGLLG 1169
               ||..|:.|..:|.|...|.:....|::..:||.|  :|    |||:.:|.|::...|.||||
Human  1354 VLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVY--EQRVPLLAVDRLSLAVQKGECFGLLG 1416

  Fly  1170 PNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFL 1234
            .|||||||||||:.||.|:..|:.::.|:.:.....|..:.:|||||.|:..:.:|||::|.::.
Human  1417 FNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYA 1481

  Fly  1235 LIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVD 1298
            .:.|.|.:.:....|..........|.:|.:..||||.|||::..:| .|..::|.|||||.|:|
Human  1482 RLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMD 1546

  Fly  1299 PASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTL 1363
            |.:||.:|..:....:.|||:::|||:|:|..|||::..|:|.|....:||.||:|:|...|.:|
Human  1547 PVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611

  Fly  1364 KLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI-SKDTSWSEIFEYVEGNRSS 1427
            :  ..||.:.....|.:.:..:.:|:|.:.|:::::  |.:.:.: .:|.||:::|..:|..:..
Human  1612 R--AKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQ--GMVHYHLPGRDLSWAKVFGILEKAKEK 1672

  Fly  1428 WHLEDYSLSQPSLEDAFEEIA 1448
            :.::|||:||.|||..|...|
Human  1673 YGVDDYSVSQISLEQVFLSFA 1693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42816NP_730301.3 CcmA 336..643 CDD:224054 123/310 (40%)
ABC_subfamily_A 339..556 CDD:213230 96/220 (44%)
ABC2_membrane_3 <821..1018 CDD:289468 60/227 (26%)
CcmA 1135..1450 CDD:224054 112/320 (35%)
ABC_subfamily_A 1136..1354 CDD:213230 86/222 (39%)
ABCA3NP_001080.2 ABC2_membrane_3 <271..469 CDD:289468 59/207 (29%)
CcmA 530..839 CDD:224054 121/308 (39%)
ABC_subfamily_A 530..751 CDD:213230 96/220 (44%)
ABC2_membrane_3 923..1261 CDD:289468 79/358 (22%)
ABC_subfamily_A 1381..1602 CDD:213230 86/222 (39%)
drrA 1397..1692 CDD:130256 106/298 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 160 1.000 Domainoid score I4044
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X215
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.830

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