Protein Alignment CG42816 and ABCA1

DIOPT Version :10

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_005493.2
• Gene: ABCA1 / 19
• HGNCID: 29
• Length: 2261
• Species: Homo sapiens
• Alignment Length: 1726
• Identity: 461/1726 - (26%)
• Similarity: 773/1726 - (44%)
• Gaps: 381/1726 - (22%)

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKT---QGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIII 75
            ||..:|..:.|..|:.......||   ...:.:|...|    .||....|.::.    :.:.:..
Human   592 GFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVD----DIFLRVMSRSMP----LFMTLAW 648

  Fly    76 FFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSEI 140
            .:.|..:.|.||.|||.:||.|:.:||:.:.:.|.:|:|.:.|..|:.:.::.:..||.
Human   649 IYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLG------ 707

  Fly   141 SFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSEG 205
            :.:|::..|:....|.|.:..||...||:|:|.|.....:....:.....|||:::..:.....|
Human   708 NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVG 772

  Fly   206 --LNVFLSLFLLSGLQVLVVG-----ICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILAS 263
              |.:|.||     |..:..|     ..::|:.|.|:||.||||:.......::...:.:|:..:
Human   773 FTLKIFASL-----LSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDT 832

  Fly   264 FLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCC-----STESLLPYSRLFNRIFGIYSAAPDEERP 323
            ||..::..|:|.:.||.||:|:||:||||:..     |.|...|.|              :::|.
Human   833 FLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGS--------------NQKRI 883

  Fly   324 DLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAG 386
            ....:|.:|.....||.|:.|.|.:  |....|..::.:.:|||||..:|||||||||.:|:|.|
Human   884 SEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948

  Fly   387 FISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQ 451
            ...||||||.|.|.|||.|....::.:|:|||.||||..|:...||..::||:||....||:|::
Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013

  Fly   452 NYLKKLNLQEKK-RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEA 515
            .....:.|...| :.....||||.||:||||.:..||.||:|.|||:.|:||.:||.:|.|:|:.
Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078

  Fly   516 KEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDA------------SCLITCE 568
            ::|.||:|:||.:|:.:|||||:.|||.|:|.|:||..|||.|:..            |.|.:|.
Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143

  Fly   569 --------ARKR----------------------CDLEKLTSLISRHVGTIQPFSIKGRDVCYKL 603
                    .:|.                      .|:..:::||.:||...:.....|.::.|.|
Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208

  Fly   604 PLSKSK--YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED-LNSRQSGGA-------- 657
            |...:|  .|..||.:::.:::.||:..:.:|..:|||||:....|. :::..|.|.
Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRR 1273

  Fly   658 ---------------EKRDDDDRDDDEENEV------QDGNVRSCKKQWR-------AMMTKKVM 694
                           :..|.:|.|.|.|:..      .||......|.|:       |::.|:::
Human  1274 AFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLL 1338

  Fly   695 -ALYDNKVYFLLLLLTPIVYYITTLMMATKPHHSGRP-------------TFNISDYGVDKFTIL 745
             |....|.:|..::|..:...|..:.....|.....|             ||..:|...|..|:.
Human  1339 IARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLE 1403

  Fly   746 L---------------------------------SVPVSKSYTE--------------------- 756
            |                                 :.||.::..:
Human  1404 LLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSD 1468

  Fly   757 ----------------------ERRADSIAS---------LIKGKLKLIVVSEQIKDYVDD---- 786
                                  :..||.:..         |:|..:::|..|.:.|.:|::
Human  1469 KIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYG 1533

  Fly   787 -------KWKSREGRREIN--------FVSMAID-TGDR---------TGL------------IG 814
                   ..::....:|:|        .:.:|.| :.||         |||            .|
Human  1534 GFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKG 1598

  Fly   815 WVGPRHYVHAAPMILNLVYNAL----AQELIGPK-ISIEVTSVPFTLRKK---EDFLISNNGDI- 870
            |       ||....||::.||:    .|:...|. ..|...:.|..|.|:   |..|::.:.|:
Human  1599 W-------HAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVL 1656

  Fly   871 ----PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM----------V 921
                .|:.:.:|..:.::|   :||||||..|.||.:||::.:.||||:..:||          :
Human  1657 VSICVIFAMSFVPASFVVF---LIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVI 1718

  Fly   922 VFFIL-------------VLALLLPLYGYAPWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAV 972
            :.||.             ||||||.|||::             :..|:: ..|:..:.|..:
Human  1719 IIFICFQQKSYVSSTNLPVLALLLLLYGWS-------------ITPLMYPASFVFKIPSTAY--- 1767

  Fly   973 SMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQN 1037
             ::|.||   :|.:.|.|::|.....::....:.|::.::.....|   |.:..|....|...:|
Human  1768 -VVLTSV---NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLI---FPHFCLGRGLIDMVKN 1825

  Fly  1038 PLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAIILFLLIMFFEYGSCVWYR 1098
            ....:...         .|.|.|  .|:|::|.    ::..|....::.||:.:..:|...:..|
Human  1826 QAMADALE---------RFGENR--FVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPR 1879

  Fly  1099 CKGCCPYSSKGS---IEDPKVSREAEKIRAMDADQIGTR-ALVVNGVSKKYGCDQL-AVNNISFA 1158
                 |.::|.|   .||..|.||.::|    .|..|.. .|.:..::|.|...:. ||:.|...
Human  1880 -----PVNAKLSPLNDEDEDVRRERQRI----LDGGGQNDILEIKELTKIYRRKRKPAVDRICVG 1935

  Fly  1159 LKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEF 1223
            :.|..|.||||.|||||::||||:.|:.::.:|:.:::..|:....::..:.:|||||.|:..|.
Human  1936 IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITEL 2000

  Fly  1224 LTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSL 1287
            ||||:.::.|.|:.|.|.|::.|..|....:.|..|:.:|....||||.|||::.|:| .|...:
Human  2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPV 2065

  Fly  1288 ICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQH 1352
            :.||||:.|:||.:||.:|.....|.::|::|:||||:|:|..|||::..|:|:|....:|||||
Human  2066 VFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQH 2130

  Fly  1353 VKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI-SKDTSWS 1415
            :||:...|.|:.: :....||     |..::|...:.:|.:.||||:.  ..|.:|: |..:|.:
Human  2131 LKNRFGDGYTIVVRIAGSNPD-----LKPVQDFFGLAFPGSVLKEKHR--NMLQYQLPSSLSSLA 2188

  Fly  1416 EIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            .||..:..::...|:||||:||.:|:..|...|:::
Human  2189 RIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	448/1654 (27%)
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	461/1726 (27%)
		Annulus domain 1. /evidence=ECO:0000305|PubMed:35974019	69..80
		Annulus domain 2. /evidence=ECO:0000305|PubMed:35974019	368..379
		Gateway domain. /evidence=ECO:0000305|PubMed:35974019	564..594		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1283..1312		5/28 (18%)