DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and ABCA1

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_005493.2	Gene:	ABCA1 / 19	HGNCID:	29	Length:	2261	Species:	Homo sapiens

Alignment Length:	1726	Identity:	461/1726 - (26%)
Similarity:	773/1726 - (44%)	Gaps:	381/1726 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKT---QGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIII 75
            ||..:|..:.|..|:.......||   ...:.:|...|    .||....|.::.    :.:.:..
Human   592 GFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVD----DIFLRVMSRSMP----LFMTLAW 648

  Fly    76 FFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSEI 140
            .:.|..:.|.||.|||.:||.|:.:||:.:.:.|.:|:|.:.|..|:.:.::.:..||.
Human   649 IYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLG------ 707

  Fly   141 SFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSEG 205
            :.:|::..|:....|.|.:..||...||:|:|.|.....:....:.....|||:::..:.....|
Human   708 NLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVG 772

  Fly   206 --LNVFLSLFLLSGLQVLVVG-----ICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILAS 263
              |.:|.||     |..:..|     ..::|:.|.|:||.||||:.......::...:.:|:..:
Human   773 FTLKIFASL-----LSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDT 832

  Fly   264 FLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCC-----STESLLPYSRLFNRIFGIYSAAPDEERP 323
            ||..::..|:|.:.||.||:|:||:||||:..     |.|...|.|              :::|.
Human   833 FLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGS--------------NQKRI 883

  Fly   324 DLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAG 386
            ....:|.:|.....||.|:.|.|.:  |....|..::.:.:|||||..:|||||||||.:|:|.|
Human   884 SEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTG 948

  Fly   387 FISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQ 451
            ...||||||.|.|.|||.|....::.:|:|||.||||..|:...||..::||:||....||:|::
Human   949 LFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEME 1013

  Fly   452 NYLKKLNLQEKK-RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEA 515
            .....:.|...| :.....||||.||:||||.:..||.||:|.|||:.|:||.:||.:|.|:|:.
Human  1014 QMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078

  Fly   516 KEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDA------------SCLITCE 568
            ::|.||:|:||.:|:.:|||||:.|||.|:|.|:||..|||.|:..            |.|.:|.
Human  1079 RQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCR 1143

  Fly   569 --------ARKR----------------------CDLEKLTSLISRHVGTIQPFSIKGRDVCYKL 603
                    .:|.                      .|:..:::||.:||...:.....|.::.|.|
Human  1144 NSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVL 1208

  Fly   604 PLSKSK--YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED-LNSRQSGGA-------- 657
            |...:|  .|..||.:::.:::.||:..:.:|..:|||||:....|. :::..|.|.
Human  1209 PYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRR 1273

  Fly   658 ---------------EKRDDDDRDDDEENEV------QDGNVRSCKKQWR-------AMMTKKVM 694
                           :..|.:|.|.|.|:..      .||......|.|:       |::.|:::
Human  1274 AFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLL 1338

  Fly   695 -ALYDNKVYFLLLLLTPIVYYITTLMMATKPHHSGRP-------------TFNISDYGVDKFTIL 745
             |....|.:|..::|..:...|..:.....|.....|             ||..:|...|..|:.
Human  1339 IARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLE 1403

  Fly   746 L---------------------------------SVPVSKSYTE--------------------- 756
            |                                 :.||.::..:
Human  1404 LLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSD 1468

  Fly   757 ----------------------ERRADSIAS---------LIKGKLKLIVVSEQIKDYVDD---- 786
                                  :..||.:..         |:|..:::|..|.:.|.:|::
Human  1469 KIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYG 1533

  Fly   787 -------KWKSREGRREIN--------FVSMAID-TGDR---------TGL------------IG 814
                   ..::....:|:|        .:.:|.| :.||         |||            .|
Human  1534 GFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKG 1598

  Fly   815 WVGPRHYVHAAPMILNLVYNAL----AQELIGPK-ISIEVTSVPFTLRKK---EDFLISNNGDI- 870
            |       ||....||::.||:    .|:...|. ..|...:.|..|.|:   |..|::.:.|:
Human  1599 W-------HAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVL 1656

  Fly   871 ----PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM----------V 921
                .|:.:.:|..:.::|   :||||||..|.||.:||::.:.||||:..:||          :
Human  1657 VSICVIFAMSFVPASFVVF---LIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVI 1718

  Fly   922 VFFIL-------------VLALLLPLYGYAPWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAV 972
            :.||.             ||||||.|||::             :..|:: ..|:..:.|..:
Human  1719 IIFICFQQKSYVSSTNLPVLALLLLLYGWS-------------ITPLMYPASFVFKIPSTAY--- 1767

  Fly   973 SMILLSVIIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQN 1037
             ::|.||   :|.:.|.|::|.....::....:.|::.::.....|   |.:..|....|...:|
Human  1768 -VVLTSV---NLFIGINGSVATFVLELFTDNKLNNINDILKSVFLI---FPHFCLGRGLIDMVKN 1825

  Fly  1038 PLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAIILFLLIMFFEYGSCVWYR 1098
            ....:...         .|.|.|  .|:|::|.    ::..|....::.||:.:..:|...:..|
Human  1826 QAMADALE---------RFGENR--FVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPR 1879

  Fly  1099 CKGCCPYSSKGS---IEDPKVSREAEKIRAMDADQIGTR-ALVVNGVSKKYGCDQL-AVNNISFA 1158
                 |.::|.|   .||..|.||.::|    .|..|.. .|.:..::|.|...:. ||:.|...
Human  1880 -----PVNAKLSPLNDEDEDVRRERQRI----LDGGGQNDILEIKELTKIYRRKRKPAVDRICVG 1935

  Fly  1159 LKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEF 1223
            :.|..|.||||.|||||::||||:.|:.::.:|:.:::..|:....::..:.:|||||.|:..|.
Human  1936 IPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITEL 2000

  Fly  1224 LTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSL 1287
            ||||:.::.|.|:.|.|.|::.|..|....:.|..|:.:|....||||.|||::.|:| .|...:
Human  2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPV 2065

  Fly  1288 ICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQH 1352
            :.||||:.|:||.:||.:|.....|.::|::|:||||:|:|..|||::..|:|:|....:|||||
Human  2066 VFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQH 2130

  Fly  1353 VKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQI-SKDTSWS 1415
            :||:...|.|:.: :....||     |..::|...:.:|.:.||||:.  ..|.:|: |..:|.:
Human  2131 LKNRFGDGYTIVVRIAGSNPD-----LKPVQDFFGLAFPGSVLKEKHR--NMLQYQLPSSLSSLA 2188

  Fly  1416 EIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            .||..:..::...|:||||:||.:|:..|...|:::
Human  2189 RIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	131/353 (37%)
		ABC_subfamily_A	339..556	CDD:213230	102/219 (47%)
		ABC2_membrane_3	<821..1018	CDD:289468	57/233 (24%)
		CcmA	1135..1450	CDD:224054	114/318 (36%)
		ABC_subfamily_A	1136..1354	CDD:213230	85/219 (39%)
ABCA1	NP_005493.2	rim_protein	6..2236	CDD:130324	461/1726 (27%)
ABCA1	NP_005493.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1283..1312		5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4044
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730