DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and abt-1

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001293854.1	Gene:	abt-1 / 182849	WormBaseID:	WBGene00000019	Length:	1558	Species:	Caenorhabditis elegans

Alignment Length:	1629	Identity:	300/1629 - (18%)
Similarity:	586/1629 - (35%)	Gaps:	434/1629 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIIIFFVV 79
            |..|..|:...|:.:...||.|                .:.|:.|.  |:|..:..:|
Worm    93 FSTVIDAIHLTHLDYPHLEFTK----------------KLEKAKNK--LEDGEVDFLV------- 132

  Fly    80 VSLTKSIVEE-KELQLKVTLNLMGV--GSCLQ------------------------WVA------ 111
              |.|:::|. |:::.|: ::..||  ..|:|                        |:.
Worm   133 --LFKTLIETGKKIEYKI-ISEQGVFDKHCIQCDVHRKKTWGNAVEAQVVVNRFLYWLVKSRGFN 194

  Fly   112 -----WYIQTFII--------FLIGSSIITLFWKLVLP---------NSEIS------FMPF--- 145
                 |.:....:        ||...|.:.|.|.|:||         |::.|      |:..
Worm   195 KRSPHWQLSNVYVKHSGNDPMFLKRQSDLFLLWILLLPICSRLIDLWNNDRSSGYYNMFLSLHAR 259

  Fly   146 -THWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALI--------ATYLPFLILHSKG 201
             .|:.:|.||.           :...:||     |||:.|:..:        :|||.|::.:: .
Worm   260 RFHYFIAKFVF-----------WYGIALI-----ISLIVFIVNVLVVPAVFCSTYLQFVVCYA-A 307

  Fly   202 CSEGLNVFLS-------LFL-LSGLQVLVVGICMWEDYGEGLQWGNL--------------FETS 244
            |.....:||:       ||. :.|...:|.|     ::|.|..:..:              |:..
Worm   308 CIISFAIFLATTFPGSPLFAKIVGFLSMVAG-----EFGFGTVYHGIGFFQLCVRHFGKSEFDGP 367

  Fly   245 WPGGTLSV---GYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSR- 305
            |.....::   |..:|::.::.:.....||:..:        |..::||..:    :..:|.:|
Worm   368 WIDAVCTLCMTGNCVLLITVSIYFDTYFCLFTME--------PLAFYFPLEK----DYWMPEARS 420

  Fly   306 ------LFNRIFGI--------YSAAPDEERP-----DLQLIEPDPVDK-IAGVQIRGLSKTFGK 350
                  ...:|..:        ...|.||..|     ..:.|.|.|:.| :..|.:.|:.|....
Worm   421 PQLDTFFVKQIILLKPGRSEITVKKAHDEILPAKTSTGSKYIPPTPIVKGVPLVVLYGICKRIEN 485

  Fly   351 MEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGL 415
            ...||.||..:..|::..|.||:|.|...::|::||.:.|..|..::         .|:||.:.:
Worm   486 HWRVKQVSLTVHLGEVVTLYGHHGCGSGEILSIIAGQMKPEYGEVMM---------EQSQRPLMI 541

  Fly   416 CPQQNV-LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLS 479
            ....:| ...:|:.:.:::|.|::||:..:  .|.:...|::|:|.:.|..:...||...:.||.
Worm   542 SKTTDVPNVNYLNVIQYLRLISKMRGVSAS--TSHIDEMLEELDLIKVKNRSLDLLSTTQKERLR 604

  Fly   480 VACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDG 544
            :|....|...:::.|.|:....|..:..::|.|.:.||..:|:::::..::.|.:.|:||::|:|
Worm   605 IAAVFVGQPDLVLIDFPTMECLPEWKFMVFRFIEKRKEKRSIIVSSYDPEETEAISDKVVLMSEG 669

  Fly   545 QLRCIGSLPFLKKQVDASCLITCEARKRCDLEKLTSLI-SRHVGTIQP------FSIKGRDVCYK 602
            .:...||....|..:::...|......|...|::..:: :..:|..|.      |......:...
Worm   670 YVVLNGSCEAFKHSINSVFEIRIWPNNRFTDEQIKGMMKTLTLGDNQMKNDARFFETPNGKIRVT 734

  Fly   603 LPLSKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDD 667
            ||:...:....:.|:|::......:..:.|...::.:|:.:...|.
Worm   735 LPILYRRSIPLILRELDAVHEKFRIEFYELGKPNIHDIYANACYEH------------------- 780

  Fly   668 DEENEVQDGNVRSCKKQWRAMMTKKVMALYDNKVYFL-----------LLLLTPIV---YYITTL 718
                  |..:..|...|.|...||:  ...:.|.||.           .|:.|..|   :.|.|:
Worm   781 ------QQLDPLSTFDQLRDHYTKQ--QPLNKKTYFFKNMIHIFKDGRFLIETAAVVGLFLILTV 837

  Fly   719 MMATKPHHSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDY 783
            ::....|.....:....:..:..:...:::     |.:|...:.|..:...|...::..|..:..
Worm   838 IILLSYHSVESDSHQTREISLTSYESPITI-----YCDECEKEVIEGVTFEKKSRVLQLENNQAV 897

  Fly   784 VDDKWK-SREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELIG--PKI 845
            :  .|| :.:..:|:    :.:..||....:             ::.|...:.:..::.|  |:|
Worm   898 L--YWKDTAKADKEL----ITVSRGDALFTM-------------IVQNFAVSQMISKITGKHPQI 943

  Fly   846 SIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMIT 910
            .:              ||.|.|......:.|:.::...|.||....       :|.|...|..||
Worm   944 KL--------------FLESENVRTATEISGFSTVFNDISSSKAAM-------ILTESYSLMYIT 987

  Fly   911 YWLSHLAFDMVVF-FILVLALLLPLYGYAPWYLLL---CVLFFTGLAGLIFIY----FLISMLSA 967
                 ..|.|.|: |.:||.|.|......|..::|   ..::|    |.|:::    ||:..:..
Worm   988 -----AVFQMFVYTFSVVLPLRLVSTNMGPQSMILPWPRYVYF----GFIYVFQLVVFLVIAIIL 1043

  Fly   968 TFLAVSMILLSVIIGSLILMILGA--------LALIFKMVYVAIYVANMHPLIAGYNCIQKCFHY 1024
            .|..:||...:....|..|..|.|        |.||:.:|:......::.|:|...:.:...|
Worm  1044 GFAVLSMGFFATNTTSCYLRFLSAWFLSYASTLPLIYFLVFNIQNTKSVIPIILAISSLSVTF-- 1106

  Fly  1025 MSLCGSYISEAQNPLSENLTSDEMYC-INPLAFLEPRCVCV--------NPMTWPDMLVMLGT-- 1078
            .:|..|:.:|.|..|...:......| :||.:.|:.....:        |..|...:::..|.
Worm  1107 PNLVASFSAENQVSLQSLIQFVSWSCMLNPPSSLQVLAAFLNAGESLEKNSGTITSLILFCGAQF 1171

  Fly  1079 -AIILFLLIMF---FEYGSCVWYRCKGCCPYSS-----------------------KGSIEDPK- 1115
             .|::|:|::|   |.|....|:: .....|||                       .|::||.:
Worm  1172 WIIVIFVLVIFQPGFSYIQQYWFK-SSTVLYSSFERGTTLKPGARIKNSYIFVTNPLGTMEDAQD 1235

  Fly  1116 -------VSREA---EKIRAMDADQIGTRALVVNGVSKKYGCDQLAVNNISFALKPSHCVGLLGP 1170
                   .:|.|   |.::...:|.|...::.::.:|.....::..|..::
Worm  1236 KGASGNIPNRPAAGTEPVQKPTSDYIAGSSMSIDDMSYITNYEENLVEKMA-------------- 1286

  Fly  1171 NGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKR---------NKAMKELGYCPQSDSFFEFLTG 1226
                 |.|......|..:|....::.|...::|.         || .:.:.:.|..::.....|.
Worm  1287 -----TMTSWNDKQEVPVDNSATFLMGDQTKLKSALLTTIAKINK-NEHIAFVPIVENISTIYTP 1345

  Fly  1227 RQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKR--KINAAVACGANSLIC 1289
            .:||:......||...|  .....|.|.|..::|.:.:|.......:|  .:.|.:....| ::.
Worm  1346 FELLENAAYCNGFEITD--DHISYLLDAFDLKEHANTQIKLLPCIDRRILMLLAKLVIKPN-IVI 1407

  Fly  1290 LDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHN--MDEINALCSKSVI-------LVDGSIY 1345
            :|:....:..:....||:....:.:.|..::.|||:  ..|..|.|...:.       |:..||.
Worm  1408 IDQLEMFLPHSKMMTVWSFCARLRKNGLGIIYTSHHSGFAEHTATCCAHMYKGQFVRNLLPTSIK 1472

  Fly  1346 AMGSVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEF---SGRLTFQ 1407
            |..:|..|..|.|.          .|..::.||.|            |::|..:.   |..:|..
Worm  1473 AKCTVLEVVPKTAS----------DPKVLLHMLQK------------EMEESVKLPSTSRNITLA 1515

  Fly  1408 ISKD 1411
            :.||
Worm  1516 MYKD 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	67/314 (21%)
		ABC_subfamily_A	339..556	CDD:213230	54/217 (25%)
		ABC2_membrane_3	<821..1018	CDD:289468	45/214 (21%)
		CcmA	1135..1450	CDD:224054	53/300 (18%)
		ABC_subfamily_A	1136..1354	CDD:213230	40/237 (17%)
abt-1	NP_001293854.1	rim_protein	<256..>676	CDD:130324	96/464 (21%)
		P-loop_NTPase	474..677	CDD:393306	53/213 (25%)
		ABC2_membrane_3	<917..1176	CDD:378925	60/303 (20%)
		CcmA	<1328..1491	CDD:224054	34/175 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920