Protein Alignment CG42816 and ced-7

DIOPT Version :9

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_001255012.1
• Gene: ced-7 / 176352
• WormBaseID: WBGene00000421
• Length: 1758
• Species: Caenorhabditis elegans
• Alignment Length: 1613
• Identity: 414/1613 - (25%)
• Similarity: 689/1613 - (42%)
• Gaps: 320/1613 - (19%)

  Fly     7 SYPLYKTGFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPI--KDLPSPPIFKSDNSSTLQDVGIM 69
            |.|.:.:.||..|.|:....:       :..|......||  :.||.|. :|:.:.|...|....
 Worm   274 SPPYWTSAFLTFQHAIESSFL-------SSVQSGAPDLPITLRGLPEPR-YKTSSVSAFIDFFPF 330

  Fly    70 IIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAW----YIQTFIIFLIGSSIITLF 130
            |...:.|..|:.:|:.|..|.. .:|..|..||:.:.:.:.|.    :::.|:|||
 Worm   331 IWAFVTFINVIHITREIAAENH-AVKPYLTAMGLSTFMFYAAHVVMAFLKFFVIFL--------- 385

  Fly   131 WKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLP-- 193
                     .|.:|.|      ||:..:|...:..:.||       |.:..|.|.|.:|::..
 Worm   386 ---------CSIIPLT------FVMEFVSPAALIVTVLM-------YGLGAVIFGAFVASFFNNT 428

  Fly   194 ----FLILHSKGCSEGLNVFL-------SLFLLSGLQV---LVVGICMWEDY---GEGLQWGNLF 241
                ..||.:.|...|::..|       |...|.||.:   ..:.:....||   ...|...|:|
 Worm   429 NSAIKAILVAWGAMIGISYKLRPELDQISSCFLYGLNINGAFALAVEAISDYMRRERELNLTNMF 493

  Fly   242 ETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRL 306
            ..|  ....|:|:.|::||:......:..|.::.||                   |.:......|
 Worm   494 NDS--SLHFSLGWALVMMIVDILWMSIGALVVDHIR-------------------TSADFSLRTL 537

  Fly   307 FNRIFGIYSAAPDEE-----------RPDLQL-------IEPDPVDK-----------------I 336
            |:     :.|..|:|           |.:.|:       :.|...|.                 .
 Worm   538 FD-----FEAPEDDENQTDGVTAQNTRINEQMNPMASTSLNPPNADSDSLLEGSTEADGARDTAR 597

  Fly   337 AGVQIRGLSK---TFGKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALIN 398
            |.:.:|.|.|   |.|: ..|..:|.....||.::|:|||||||:|..|.:||.|.||:|...|.
 Worm   598 ADIIVRNLVKIWSTTGE-RAVDGLSLRAVRGQCSILLGHNGAGKSTTFSSIAGIIRPTNGRITIC 661

  Fly   399 GFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKK 463
            |:|:..|..:.:|.||:|||.|.|:..|:...|::|...|:|.|..:.|.:::..|..:.|..|:
 Worm   662 GYDVGNEPGETRRHIGMCPQYNPLYDQLTVSEHLKLVYGLKGAREKDFKQDMKRLLSDVKLDFKE 726

  Fly   464 RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQL 528
            ...|.|||||.:|:|.|..:|.|..:|::.|||:.|:||.||:::.:|:...|...|||||||.:
 Worm   727 NEKAVNLSGGMKRKLCVCMALIGDSEVVLLDEPTAGMDPGARQDVQKLVEREKANRTILLTTHYM 791

  Fly   529 DDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLITCEARKRCDLEK----LTSLISRHVGTI 589
            |:.|.|||.|.|:|.|:|...|:..:||::.....|:|.......|..|    ||.:.:.:|...
 Worm   792 DEAERLGDWVFIMSHGKLVASGTNQYLKQKFGTGYLLTVVLDHNGDKRKMAVILTDVCTHYVKEA 856

  Fly   590 QPFSIKGRDVCYKLPLSKSKYFSSLFRDLE--------------------SQMNILGVRGFSLSS 634
            :...:.|:.:...||.::.|.|..||:.||                    ||:..|.:|.|.||.
 Worm   857 ERGEMHGQQIEIILPEARKKEFVPLFQALEAIQDRNYRSNVFDNMPNTLKSQLATLEMRSFGLSL 921

  Fly   635 VSLEEIFMSFG-------AEDLNSRQSGGAEKRDD------------DDRDDDEENEVQDGNVRS 680
            .:||::|::.|       |...|||.|..:....:            ..:..|...::.|...|.
 Worm   922 NTLEQVFITIGDKVDKAIASRQNSRISHNSRNASEPSLKPAGYDTQSSTKSADSYQKLMDSQARG 986

  Fly   681 CKK--------QWRAMMTKKVMALYDNKVYFLLLLLTPIVYY-----ITTLMMATKPHHSGRPTF 732
            .:|        |:.::|.||.:....|.......:|.||:..     :|||........|.|
 Worm   987 PEKSGVAKMVAQFISIMRKKFLYSRRNWAQLFTQVLIPIILLGLVGSLTTLKSNNTDQFSVR--- 1048

  Fly   733 NISDYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDYVDDKWKSREGRREI 797
            :::..|::...::...   ::.|....|.:...:::......|::...|:.:.:..||..|....
 Worm  1049 SLTPSGIEPSKVVWRF---ENGTIPEEAANFEKILRKSGGFEVLNYNTKNPLPNITKSLIGEMPP 1110

  Fly   798 NFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQELIGPKISIEVTSVPFTLRKKEDF 862
            ..:.|.:::.:...|..    ..|.|..|.:::::..|   .|.| .:..|::|..|...|.
 Worm  1111 ATIGMTMNSDNLEALFN----MRYYHVLPTLISMINRA---RLTG-TVDAEISSGVFLYSKS--- 1164

  Fly   863 LISNNGDIPIYVIGYVSIAMII---------FSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAF 918
             .||:..:|..:|..:...|:|         |...:|:||.......|.::|:..||::.:.|.:
 Worm  1165 -TSNSNLLPSQLIDVLLAPMLILIFAMVTSTFVMFLIEERTCQFAHQQFLTGISPITFYSASLIY 1228

  Fly   919 DMVVFFILVLALLLPLYGYAPW---YLLLCVLFFTGLAGLIFIYFLIS---MLSATFL------- 970
            |.:::.::.|..|.....: .|   :|.:.:||:       |:||..|   :.:.:||
 Worm  1229 DGILYSLICLIFLFMFLAF-HWMYDHLAIVILFW-------FLYFFSSVPFIYAVSFLFQSPSKA 1285

  Fly   971 AVSMILLSVIIGSLILMILGALALIF------KMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCG 1029
            .|.:|:..|:|....|:.:..:.:||      |.:.|.|::.    |:..|           ..|
 Worm  1286 NVLLIIWQVVISGAALLAVFLIFMIFNIDEWLKSILVNIFMF----LLPSY-----------AFG 1335

  Fly  1030 SYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWPDM---LVMLGT----AIILFLLIM 1087
            |.|... |.....|.|:|:                  |.|...   ..::||    :..||:|:.
 Worm  1336 SAIITI-NTYGMILPSEEL------------------MNWDHCGKNAWLMGTFGVCSFALFVLLQ 1381

  Fly  1088 F---FEYGSCVWYRCKGCCPYSSKGSIED--------PKVSREAEKIRAMDADQIGTRALVVNGV 1141
            |   ..:.|.||     ....||..:::.        ..||.|.|::..:::.   ..|||:..:
 Worm  1382 FKFVRRFLSQVW-----TVRRSSHNNVQPMMGDLPVCESVSEERERVHRVNSQ---NSALVIKDL 1438

  Fly  1142 SKKYGCDQLAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNK 1206
            :|.:| ...|||.:..|:....|.||||.|||||||||.::.|:.....|...|.|..:     .
 Worm  1439 TKTFG-RFTAVNELCLAVDQKECFGLLGVNGAGKTTTFNILTGQSFASSGEAMIGGRDV-----T 1497

  Fly  1207 AMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGG 1271
            .:..:|||||.|:....||||:.|::...:.||  ::...:.|.:.:..|...|.||.:.:||||
 Worm  1498 ELISIGYCPQFDALMLDLTGRESLEILAQMHGF--ENYKAKAELILECVGMIAHADKLVRFYSGG 1560

  Fly  1272 TKRKINAAVACGA-NSLICLDEPSAGVDPASRRHVWTIINEVAQ-QGKAVLLTSHNMDEINALCS 1334
            .||||:..||..| ..:|.||||:||:||.:||.||.::....: ...|::||||:|||..||||
 Worm  1561 QKRKISVGVALLAPTQMIILDEPTAGIDPKARREVWELLLWCREHSNSALMLTSHSMDECEALCS 1625

  Fly  1335 KSVILVDGSIYAMGSVQHVKNKIAKG--MTLKLVVNVQPDNMVAML-TKIEDDIY-MTYPNAELK 1395
            :..:|..||:.|:||.|.:|:.....  |||.|....|.|.:|.:: |::.:.:. .|..|..|.
 Worm  1626 RIAVLNRGSLIAIGSSQELKSLYGNNYTMTLSLYEPNQRDMVVQLVQTRLPNSVLKTTSTNKTLN 1690

  Fly  1396 EKYEFSGRLTFQISKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIA 1448
            .|::...      .|:..||..||.|:.......::|:.|:|.|||:.|..:|
 Worm  1691 LKWQIPK------EKEDCWSAKFEMVQALAKDLGVKDFILAQSSLEETFLRLA 1737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	116/333 (35%)
		ABC_subfamily_A	339..556	CDD:213230	87/219 (40%)
		ABC2_membrane_3	<821..1018	CDD:289468	50/224 (22%)
		CcmA	1135..1450	CDD:224054	115/320 (36%)
		ABC_subfamily_A	1136..1354	CDD:213230	87/219 (40%)
ced-7	NP_001255012.1	ABC2_membrane_3	<286..445	CDD:289468	42/198 (21%)
		CcmA	600..885	CDD:224054	103/285 (36%)
		ABC_subfamily_A	600..819	CDD:213230	87/219 (40%)
		ABC2_membrane_3	1014..1379	CDD:289468	81/424 (19%)
		ABC2_membrane_4	1154..1348	CDD:289500	47/221 (21%)
		CcmA	1430..1738	CDD:224054	115/322 (36%)
		ABC_subfamily_A	1433..1645	CDD:213230	87/219 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930