DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and ABCA13

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_011513432.1	Gene:	ABCA13 / 154664	HGNCID:	14638	Length:	5059	Species:	Homo sapiens

Alignment Length:	1555	Identity:	413/1555 - (26%)
Similarity:	710/1555 - (45%)	Gaps:	244/1555 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LQDVGIM--IIVIIIFFV-VVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGS 124
            |.:||..  :|:::.:.| |.|:.:.:|.|:|:|::..:.:|||...:.::||:::...:..|.|
Human  3565 LNNVGFFFPLIMMLTWMVSVASMVRKLVYEQEIQIEEYMRMMGVHPVIHFLAWFLENMAVLTISS 3629

  Fly   125 SIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSH--CTICFSFLMSSLISTTYRISLVTFLAL 187
            :.:.    :||..|.|    |.|.:..:..|.:|..  ..:..|:|:|:..|.....:|.|.|..
Human  3630 ATLA----IVLKTSGI----FAHSNTFIVFLFLLDFGMSVVMLSYLLSAFFSQANTAALCTSLVY 3686

  Fly   188 IATYLPF---LILHSKGCSEGLNVFLSLFLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGT 249
            :.::||:   |:||:: .|.....||.|...:.....|..|...|....|:||.|:::....||
Human  3687 MISFLPYIVLLVLHNQ-LSFVNQTFLCLLSTTAFGQGVFFITFLEGQETGIQWNNMYQALEQGG- 3749

  Fly   250 LSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRC-CSTESLLPYSR-------- 305
            ::.|::..:::..|.|..|...||..:.||.:|:.:||:||.|.. ..:...|...|
Human  3750 MTFGWVCWMILFDSSLYFLCGWYLSNLIPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSL 3814

  Fly   306 -LFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQIRGLSKTF-GKMEVVKNVSFDMFEGQITV 368
             .||..|       |.:...||..|.:......||.:..::|.: |...||:::|...:..|||.
Human  3815 FFFNENF-------DNKGSSLQNREGELEGSAPGVTLVSVTKEYEGHKAVVQDLSLTFYRDQITA 3872

  Fly   369 LMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQ 433
            |:|.|||||||:||||.|...|||||.:|||.:::.:..:.:..:|:||||::|..:|:...|:.
Human  3873 LLGTNGAGKTTIISMLTGLHPPTSGTIIINGKNLQTDLSRVRMELGVCPQQDILLDNLTVREHLL 3937

  Fly   434 LFSRLRGLRGA--EVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEP 496
            ||:.::..:..  |:..:|...|:.::|.:.:....|.||||.:|:||:..:..|..:.::.|||
Human  3938 LFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEP 4002

  Fly   497 STGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPF-LKKQVD 560
            ::|:||.:|..||.::|:.:||.||:.|||.||:.|.|.|||.::..|:|||.|. || ||:...
Human  4003 TSGVDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGP-PFCLKEAYG 4066

  Fly   561 ASCLIT-------CEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSK-YFSSLFRD 617
            ....:|       .||....|:..:||||..::.........|.::.|.:|....| ....||:.
Human  4067 QGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQA 4131

  Fly   618 LESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQ--SGGAEKRDDDDRDDDEENEVQDGNVRS 680
            |:..::.|.:.|:.:|..:|||:|:.. .:|.|.:.  :.|.|....:.|.....:.......|.
Human  4132 LDENLHQLHLTGYGISDTTLEEVFLML-LQDSNKKSHIALGTESELQNHRPTGHLSGYCGSLARP 4195

  Fly   681 CKKQWRAMMTKKVMALYDNKVYFLLL--------LLTPIVYYITTL--------------MMATK 723
            ...|...::..:|.|:...::...|.        ||.|:::....:              :..|.
Human  4196 ATVQGVQLLRAQVAAILARRLRRTLRAGKSTLADLLLPVLFVALAMGLFMVRPLATEYPPLRLTP 4260

  Fly   724 PHHSGRPTFNISDYGVDKFTI-------------------------------------------L 745
            .|:....|:..|..|.|...:                                           .
Human  4261 GHYQRAETYFFSSSGGDNLDLTRVLLRKFRDQDLPCADLNPRQKNSSCWRTDPFSHPEFQDSCGC 4325

  Fly   746 LSVP---VSKSYTEERRADSIASLIKGKLK--LIVVSEQIKDYVDDKWKSREGRREINFVSMAID 805
            |..|   .|..|.......::.:|....::  |:..||          |.|.|..... :.:..:
Human  4326 LKCPNRSASAPYLTNHLGHTLLNLSGFNMEEYLLAPSE----------KPRLGGWSFG-LKIPSE 4379

  Fly   806 TGDRTGLIG--------WVGPRHYVHAAPMILNLVYNALAQELIGPKI-----SIEVTSVPF--T 855
            .|...|.|.        |...:.: |:.|..||.:.|.:..:.:.|.:     .|.:.|.|:  .
Human  4380 AGGANGNISKPPTLAKVWYNQKGF-HSLPSYLNHLNNLILWQHLPPTVDWRQYGITLYSHPYGGA 4443

  Fly   856 LRKKEDFL--ISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAF 918
            |..::..|  |...|.....|:|: ||......|:|:::||...|.||.:|||....||.::..:
Human  4444 LLNEDKILESIRQCGVALCIVLGF-SILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNFLY 4507

  Fly   919 DMVVFFILV-----------------------LALLLPLYGYA--PWYLLLCVLF------FTGL 952
            ||:.:.:.|                       .||||.|:|||  ||..|:..:|      |...
Human  4508 DMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSSDVAFISY 4572

  Fly   953 AGLIFIYFLISMLSATFLAVSMILLSVIIGSLILMILGALALIFKMVY-VAIYVANMHP-LIAGY 1015
            ..|.||:.|.:||    :.:...||::|          :.|...:.:| |..:|..:.| ...|.
Human  4573 VSLNFIFGLCTML----ITIMPRLLAII----------SKAKNLQNIYDVLKWVFTIFPQFCLGQ 4623

  Fly  1016 NCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWPDMLVMLGT-A 1079
            ..::.|:          ::.:..|:.|...|..  ::|..        :|.:.|  :.|.|.: .
Human  4624 GLVELCY----------NQIKYDLTHNFGIDSY--VSPFE--------MNFLGW--IFVQLASQG 4666

  Fly  1080 IILFLLIMFFEYGSCVWYRCKGCCPYSSKGSIEDPKVSREAEKIRAMDADQIGTRALVVNGVSKK 1144
            .:|.||.:...:....|.|.......:.|.| :|..|.:| || |..:....|. .||:..:||.
Human  4667 TVLLLLRVLLHWDLLRWPRGHSTLQGTVKSS-KDTDVEKE-EK-RVFEGRTNGD-ILVLYNLSKH 4727

  Fly  1145 YG---CDQLAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYI---SGYSMRM- 1202
            |.   .:.:||.:||..:....|.||||.|||||:|||||:.||.|:..|:..|   .|.::.:
Human  4728 YRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSLTSGHAIIRTPMGDAVDLS 4792

  Fly  1203 KRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITY 1267
            ....|...:|||||.|:..|.|||.:.|..:..:.|.|.:.:.:....|..:.....|.||.:..
Human  4793 SAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIPEVAGDLIRRLHLEAHADKPVAT 4857

  Fly  1268 YSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINA 1331
            ||||||||::.|:| .|...::.|||||:|:||.|:|::|..|.:..::|.|.:||||:|:|..|
Human  4858 YSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEA 4922

  Fly  1332 LCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKE 1396
            ||::..|:|:||...:||.||:||:...|.|:|:.:..:.:....    :.|.:.:.:|..:.|.
Human  4923 LCTRLAIMVNGSFKCLGSPQHIKNRFGDGYTVKVWLCKEANQHCT----VSDHLKLYFPGIQFKG 4983

  Fly  1397 KYEFSGRLTFQISKDTSW---SEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRK 1453
            ::  ...|.:.:.|  .|   :::|:.:|.|::..:::.||::|.:||..|...|.|:::
Human  4984 QH--LNLLEYHVPK--RWGCLADLFKVIENNKTFLNIKHYSINQTTLEQVFINFASEQQQ 5039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	110/318 (35%)
		ABC_subfamily_A	339..556	CDD:213230	85/220 (39%)
		ABC2_membrane_3	<821..1018	CDD:289468	60/238 (25%)
		CcmA	1135..1450	CDD:224054	111/325 (34%)
		ABC_subfamily_A	1136..1354	CDD:213230	90/225 (40%)
ABCA13	XP_011513432.1	rim_protein	3068..5049	CDD:130324	413/1555 (27%)
		ABC_subfamily_A	3842..4062	CDD:213230	85/220 (39%)
		ABC_subfamily_A	4719..4945	CDD:213230	90/225 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820