DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42816 and Abcg5

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	150/786 - (19%)
Similarity:	274/786 - (34%)	Gaps:	262/786 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 EVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPT---SGTALINGFDIRQERRQAQRCI 413
            :::|:||..:..||...::|.:|:|||||:..::|.:..|   .|...:||.::|  |.|.|.|:
  Rat    68 KILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELR--RDQFQDCV 130

  Fly   414 GLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEV---KSEVQNYLKKLNLQEKKRLAARN-----L 470
            ....|.:|....| :|.....::.:..||.:..   ..:|:..|.:|:|.........|     :
  Rat   131 SYLLQSDVFLSSL-TVRETLRYTAMLALRSSSADFYDKKVEAVLTELSLSHVADQMIGNYNFGGI 194

  Fly   471 SGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILE-AKEGCTILLTTHQLDDGEVL 534
            |.|.:||:|:|..|....||::.|||:||||......:..|::| |:....:::|.|| ...|:.
  Rat   195 SSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQ-PRSELF 258

  Fly   535 G--DRVVIISDGQLRCIGS----LPFLKKQVDASCLITCEARKR-----CDLEKL-TSLISRHVG 587
            .  |::.|::.|:|...|:    |.|..     :|...|.....     .||..: |....|.:.
  Rat   259 HHFDKIAILTYGELVFCGTPEEMLGFFN-----NCGYPCPEHSNPFDFYMDLTSVDTQSREREIE 318

  Fly   588 TIQ-----PFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAE 647
            |.:     ..:.:..|:|:|           :..::|...::..:......:.:...:|...|.
  Rat   319 TYKRVQMLESAFRQSDICHK-----------ILENIERTRHLKTLPMVPFKTKNPPGMFCKLGV- 371

  Fly   648 DLNSRQSGGAEKRDDDDRDDDEENEVQDGNVRSCKKQWRAMMTKK---VMALYDNKVYFLLLLLT 709
                                            ..::..|.:|..|   :|.|..|.:..|.|
  Rat   372 --------------------------------LLRRVTRNLMRNKQVVIMRLVQNLIMGLFL--- 401

  Fly   710 PIVYYITTLMMATKPHHSGRPTFNISDYGV-DKFTILLSVPVSKSYTEERRADSIASLIKGKLKL 773
              ::|:.            |...|:....| |:..:|..:..:..||....|.::..:::.
  Rat   402 --IFYLL------------RVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRA---- 448

  Fly   774 IVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAAPMILNLVYNALAQ 838
             |..::.:|.:..||:                                     |:|..|.:||
  Rat   449 -VSDQESQDGLYQKWQ-------------------------------------MLLAYVLHAL-- 473

  Fly   839 ELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEV 903
                          ||::                       :|.:||||
  Rat   474 --------------PFSI-----------------------VATVIFSS---------------- 485

  Fly   904 SGLEMITYWLSHLAFDMVVFFILVLALLLPLYGYAPWYLLLCVLFFTGLAGLIFIYFLISMLSAT 968
                 :.||...|..::..|.....|||.|                 .|.|......|:.|:...
  Rat   486 -----VCYWTLGLYPEVARFGYFSAALLAP-----------------HLIGEFLTLVLLGMVQNP 528

  Fly   969 FLAVSMI-LLSV---IIGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQK--C------ 1021
            .:..|:: |||:   :|||..:..:..:.:..|              |.||...||  |
  Rat   529 NIVNSIVALLSISGLLIGSGFIRNIEEMPIPLK--------------ILGYFTFQKYCCEILVVN 579

  Fly  1022 -FHYMSL-C-GSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWPDMLVM---LGTAI 1080
             |:.::. | ||..|...||:. ::|..       :.|:|..|.........:.|::   :.|.:
  Rat   580 EFYGLNFTCGGSNTSVPNNPMC-SMTQG-------IQFIEKTCPGATSRFTTNFLILYSFIPTLV 636

  Fly  1081 ILFLLI 1086
            ||.:::
  Rat   637 ILGMVV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	75/319 (24%)
		ABC_subfamily_A	339..556	CDD:213230	63/221 (29%)
		ABC2_membrane_3	<821..1018	CDD:289468	35/200 (18%)
		CcmA	1135..1450	CDD:224054
		ABC_subfamily_A	1136..1354	CDD:213230
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		ABCG_White	50..276	CDD:213201	60/211 (28%)
		3a01204	61..646	CDD:273361	150/786 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000