DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and Abca4

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_031404.1	Gene:	Abca4 / 11304	MGIID:	109424	Length:	2310	Species:	Mus musculus

Alignment Length:	1721	Identity:	455/1721 - (26%)
Similarity:	763/1721 - (44%)	Gaps:	359/1721 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPI----KDLPSPPIFKSDNSSTLQDVGIMIIVII 74
            ||..:|..:.|..:|      ::.|.:   |||    :.:|. |.|..|:...:.:....|.:::
Mouse   607 GFAYLQDMVEQGIVK------SQMQAE---PPIGVYLQQMPY-PCFVDDSFMIILNRCFPIFMVL 661

  Fly    75 IFFVVVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNS 138
            .:...||:| |.||.||||:||.||...||.:.:.|..|::.:|.|..:...::|||
Mouse   662 AWIYSVSMTVKGIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMALSIFLLTLF-------- 718

  Fly   139 EISFMPFTHWS--MALFV-LLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSK 200
             |......|:|  ..||: ||..:..||..|||:|:|.|.....:..:.:.....|||.::..:.
Mouse   719 -IMHGRILHYSDPFILFLFLLAFATATIMQSFLLSTLFSKASLAAACSGVIYFTLYLPHVLCFAW 782

  Fly   201 GCSEGLNVFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVM 259
            ......::..::.|||      |.:.||    .:|:.|.||||.|:.::...|...|....:.:|
Mouse   783 QDRMTADLKTTVSLLSSVAFGFGTEYLV----RFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMM 843

  Fly   260 ILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRC-------CSTESLLPYSRLFNRIFGIYSAA 317
            :|.:.|..||..||:::.||.||.|.||:|.....       |||..    .|...:...:....
Mouse   844 LLDAALYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTRE----ERALEKTEPLTEEM 904

  Fly   318 PDEERPD---LQLIEPDPVDKIAGVQIRGLSKTF---GKMEVVK-NVSFDMFEGQITVLMGHNGA 375
            .|.|.|:   ....|.:....:.||.::.|.|.|   |:..|.: |::|  :|.|||..:|||||
Mouse   905 EDPEHPEGMNDSFFERELPGLVPGVCVKNLVKVFEPSGRPAVDRLNITF--YENQITAFLGHNGA 967

  Fly   376 GKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRG 440
            ||||.:|:|.|.:.|||||.||.|.||.......::.:|:|||.|:||.||:...||..:::|:|
Mouse   968 GKTTTLSILTGLLPPTSGTVLIGGKDIETNLDVVRQSLGMCPQHNILFHHLTVAEHILFYAQLKG 1032

  Fly   441 LRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSAR 505
            ....|.:.|::..|:...|..|:...|::||||.||:||||.:..|..||::.|||::|:||.:|
Mouse  1033 RSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSR 1097

  Fly   506 RELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLIT---- 566
            |.:|.|:|:.:.|.||:::||.:|:.::||||:.|||.|:|.|.|:..|||........:|
Mouse  1098 RSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRK 1162

  Fly   567 ----------CEA---------RKRC---------------DLEKLTSLISRHVGTIQPFSIKGR 597
                      ||.         ..||               |:::|..|:..||...:.....|:
Mouse  1163 MKNIQSQRGGCEGVCSCTSKGFSTRCPTRVDEITEEQVLDGDVQELMDLVYHHVPEAKLVECIGQ 1227

  Fly   598 DVCYKLPLS--KSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED--LNSRQSGGAE 658
            ::.:.||..  |.:.::||||:||..:..||:..|.:|...|||||:.. .||  ..|...|||:
Mouse  1228 ELIFLLPNKNFKQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKV-TEDAGAGSMFVGGAQ 1291

  Fly   659 KRDD------------------------------DDRDDDEENEVQDGNV------RSCKKQWRA 687
            ::.:                              |........|.:|..|      |...:..:|
Mouse  1292 QKREQAGLRHPCSAPTEKLRQYAQAPHTCSPGQVDPPKGQPSPEPEDPGVPFNTGARLILQHVQA 1356

  Fly   688 MMTKKVMALYDNKVYFLLLLLTPIVYYITTLMMA----------------------------TKP 724
            ::.|:......::..|:..::.|..:....||::                            .:|
Mouse  1357 LLVKRFHHTIRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQYTFFSMDEP 1421

  Fly   725 HHS----------GRPTF----------------------------------------------- 732
            ::.          .||.|
Mouse  1422 NNEHLEVLADVLLNRPGFGNRCLKEEWLPEYPCINATSWKTPSVSPNITHLFQKQKWTAAHPSPS 1486

  Fly   733 -----------------------------------------NISDYGVDKFTILL-SVPVSKSYT 755
                                                     |||||.|..:..|: |...||.:.
Mouse  1487 CKCSTREKLTMLPECPEGAGGLPPPQRTQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWV 1551

  Fly   756 EERRADSIASLIKGKLKLIVVS-EQIKDYVDDKWK---------SREGRREINFVSMAIDTGDRT 810
            .|:|...|:  |.|||..|.:| |.:..::....:         :||..:|:......::|.|..
Mouse  1552 NEQRYGGIS--IGGKLPAIPISGEALVGFLSGLGQMMNVSGGPVTREASKEMLDFLKHLETTDNI 1614

  Fly   811 GLIGWVGPRHYVHAAPMILNLVYNALAQELIGPK------ISIEVTSVPFTLRKKE--DFLI--- 864
            .:  |...:.: ||....||:.:||:.:..: |:      ..|.|.|.|..|.|::  |..:
Mouse  1615 KV--WFNNKGW-HALVSFLNVAHNAILRASL-PRDRDPEEYGITVISQPLNLTKEQLSDITVLTT 1675

  Fly   865 SNNGDIPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFI---L 926
            |.:..:.|.||..:|.....|...:|||||:..|.||.:||:...||||::..:|::.:.:   |
Mouse  1676 SVDAVVAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWLTNFLWDIMNYAVSAGL 1740

  Fly   927 VLALLLPLYGY------APWYL--LLCVLFFTGLAGLIFIY---FLISMLSATFLAVSMILLSVI 980
            |:.:.:   |:      :|..|  |:.:|...|.|.:..:|   ||..:.|..::|:|...|.:.
Mouse  1741 VVGIFI---GFQKKAYTSPDNLPALVSLLMLYGWAVIPMMYPASFLFEVPSTAYVALSCANLFIG 1802

  Fly   981 IGSLILMILGALALIFKMVYVAIYVANMHPLIAGYNCIQK---CFHYMSLCGSYISEAQNPLSEN 1042
            |.|      .|:..:.::      ..|...|:.....::|   .|.:..|....|..|   ||:.
Mouse  1803 INS------SAITFVLEL------FENNRTLLRFNAMLRKLLIVFPHFCLGRGLIDLA---LSQA 1852

  Fly  1043 LTS-----DEMYCINPLAFLEPRCVCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCV--WYRCK 1100
            :|.     .|.|..||..:         .:...:::.|....::.|||.:..::...:  |.
Mouse  1853 VTDVYAQFGEEYSANPFQW---------DLIGKNLVAMAIEGVVYFLLTLLIQHHFFLTRWI--- 1905

  Fly  1101 GCCPYSSKGSIEDPKVSREAEKIRAMDADQIG---TRALVVNGVSKKY-GCDQLAVNNISFALKP 1161
             ..|.......||..|:.|.:::.:      |   |..|.:|.::|.| |....||:.:...::|
Mouse  1906 -AEPAREPVFDEDDDVAEERQRVMS------GGNKTDILKLNELTKVYSGSSSPAVDRLCVGVRP 1963

  Fly  1162 SHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTG 1226
            ..|.||||.|||||||||||:.|:.::..|:..::|.|:....:...:.:|||||.|:..:.|||
Mouse  1964 GECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTSISDVHQNMGYCPQFDAIDDLLTG 2028

  Fly  1227 RQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICL 1290
            |:.|.::..:.|.|||::.|.........|...:.|:....||||.|||::.|:| .|...|:.|
Mouse  2029 REHLYLYARLRGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTAIALTGCPPLLLL 2093

  Fly  1291 DEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKN 1355
            |||:.|:||.:||.:|..|..:.::|:||:||||:|:|..|||::..|:|.|:...:|::||:|.
Mouse  2094 DEPTTGMDPQARRMLWNTIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGTFQCLGTIQHLKY 2158

  Fly  1356 KIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKDTSWSEIFEY 1420
            |...|..:.:.:....|:::..|..:|......:|.:..:|::.  ..|.||: ..:|.:.||:.
Mouse  2159 KFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHH--SMLQFQV-PSSSLARIFQL 2220

  Fly  1421 VEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            :..::.|..:|:||::|.:|:..|...|:::
Mouse  2221 LISHKDSLLIEEYSVTQTTLDQVFVNFAKQQ 2251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	127/350 (36%)
		ABC_subfamily_A	339..556	CDD:213230	95/220 (43%)
		ABC2_membrane_3	<821..1018	CDD:289468	56/221 (25%)
		CcmA	1135..1450	CDD:224054	108/316 (34%)
		ABC_subfamily_A	1136..1354	CDD:213230	86/219 (39%)
Abca4	NP_031404.1	rim_protein	1..2271	CDD:130324	455/1721 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..910		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1344		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2266..2310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730