DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42816 and Abca1

DIOPT Version :10

Sequence 1:NP_730301.3 Gene:CG42816 / 39977 FlyBaseID:FBgn0261998 Length:1459 Species:Drosophila melanogaster
Sequence 2:XP_006537617.1 Gene:Abca1 / 11303 MGIID:99607 Length:2263 Species:Mus musculus


Alignment Length:1743 Identity:454/1743 - (26%)
Similarity:776/1743 - (44%) Gaps:413/1743 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSP----PIFKSDNSSTLQDVGIMIIVII 74
            ||..:|..:.|..|:.......||.     ..::.:|.|    .||....|.::.    :.:.:.
Mouse   592 GFAYLQDVVEQAIIRVLTGSEKKTG-----VYVQQMPYPCYVDDIFLRVMSRSMP----LFMTLA 647

  Fly    75 IFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSE 139
            ..:.|..:.||||.|||.:||.|:.:||:.:.:.|.:|::.:.|..|:.:.::.:..||.     
Mouse   648 WIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLG----- 707

  Fly   140 ISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGC-- 202
             :.:|::..|:....|.|.:..||...||:|:|.|.....:....:.....|||:::     |  
Mouse   708 -NLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVL-----CVA 766

  Fly   203 -----SEGLNVFLSLFLLSGLQVLVVG-----ICMWEDYGEGLQWGNLFETSWPGGTLSVGYILL 257
                 ...:.:|.||     |..:..|     ..::|:.|.|:||.||||:.......::...:.
Mouse   767 WQDYVGFSIKIFASL-----LSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVS 826

  Fly   258 VMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRC-CSTESLLPYSRLFNRIFGIYSAAPDEE 321
            :|:..:||..::..|:|.:.||.||:|:||:||||:. ...|.:...|...:...|:.....:||
Mouse   827 MMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEE 891

  Fly   322 RPDLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISML 384
            ...|:|          ||.|:.|.|.:  |....|..::.:.:|||||..:|||||||||.:|:|
Mouse   892 PTHLRL----------GVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSIL 946

  Fly   385 AGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSE 449
            .|...||||||.|.|.|||.|....::.:|:|||.||||..|:...||..::||:||....||:|
Mouse   947 TGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAE 1011

  Fly   450 VQNYLKKLNLQEKK-RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLIL 513
            ::.....:.|...| :.....||||.||:||||.:..||.||:|.|||:.|:||.:||.:|.|:|
Mouse  1012 MEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLL 1076

  Fly   514 EAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV------------------- 559
            :.::|.||:|:||.:|:.::||||:.|||.|:|.|:||..|||.|:                   
Mouse  1077 KYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSS 1141

  Fly   560 --DASCLITC-------------------EARKRC----DLEKLTSLISRHVGTIQPFSIKGRDV 599
              ::|..::|                   |.::..    |:..:::||.:||...:.....|.::
Mouse  1142 CRNSSSTVSCLKKVVPGLPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHEL 1206

  Fly   600 CYKLPLSKSK--YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED-LNSRQSGG----- 656
            .|.||...:|  .|..||.:::.:::.||:..:.:|..:|||||:....|. :::..|.|     
Mouse  1207 TYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPAR 1271

  Fly   657 ------AEKR------------DDDDRDDDEENEV------QDGNVRSCKKQWR-------AMMT 690
                  .:|:            |.:|.|.|.|:..      .||......|.|:       |::.
Mouse  1272 RNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLW 1336

  Fly   691 KKVMALYDNKVYFLLLLLTPIVYYITTLMMA---------------------------------- 721
            |:::....::..|...::.|.|:....|:.:                                  
Mouse  1337 KRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDM 1401

  Fly   722 ---------TK------------------------------------------------------ 723
                     ||                                                      
Mouse  1402 GTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQ 1466

  Fly   724 --------------PHHSGRPT----------------FNISDYGVDKFTILLSVPV-SKSYTEE 757
                          |...|.|.                .|||||.|..:..:::..: :|.:..|
Mouse  1467 CSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNE 1531

  Fly   758 RR----------------ADSIASLIKGKLKLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDT 806
            .|                :..:...||...||:.::   ||...|::.|..||    |:: .:||
Mouse  1532 FRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLT---KDSSADRFLSSLGR----FMA-GLDT 1588

  Fly   807 GDRTGLIGWVGPRHYVHAAPMILNLVYNAL----AQELIGP-KISIEVTSVPFTLRKK---EDFL 863
            .:...:  |...:.: ||....||::.||:    .|:...| :..|...:.|..|.|:   |..|
Mouse  1589 KNNVKV--WFNNKGW-HAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVAL 1650

  Fly   864 ISNNGDI-----PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM--- 920
            ::.:.|:     .|:.:.:|..:.::|   :||||||..|.||.:||::.:.||||:..:||   
Mouse  1651 MTTSVDVLVSICVIFAMSFVPASFVVF---LIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNY 1712

  Fly   921 -------VVFFIL-------------VLALLLPLYGYAPWYLLLCVLFFTGLAGLIF-IYFLISM 964
                   ::.||.             ||||||.|||::             :..|:: ..|:..:
Mouse  1713 VVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWS-------------ITPLMYPASFVFKI 1764

  Fly   965 LSATFLAVSMILLSV-IIGSLILMI--------LGALALIFKMVYVAIYVANMHPLIAGYNCIQK 1020
            .|..::.::.:.|.: |.||:...:        |..:..|.|.|:          ||..:.|:.:
Mouse  1765 PSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVF----------LIFPHFCLGR 1819

  Fly  1021 CFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAII 1081
            ....| :....:::|.....||.                   .|:|::|.    ::..|....::
Mouse  1820 GLIDM-VKNQAMADALERFGENR-------------------FVSPLSWDLVGRNLFAMAVEGVV 1864

  Fly  1082 LFLLIMFFEYGSCVWYRCKGCCPYSSK---GSIEDPKVSREAEKIRAMDADQIGTR-ALVVNGVS 1142
            .||:.:..:|...:..|     |..:|   .:.||..|.||.::|    .|..|.. .|.:..::
Mouse  1865 FFLITVLIQYRFFIRPR-----PVKAKLPPLNDEDEDVRRERQRI----LDGGGQNDILEIKELT 1920

  Fly  1143 KKYGCDQL-AVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNK 1206
            |.|...:. ||:.|...:.|..|.||||.|||||:|||||:.|:..:.:|:.:::..|:....::
Mouse  1921 KIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHE 1985

  Fly  1207 AMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGG 1271
            ..:.:|||||.|:..|.||||:.::.|.|:.|.|.|::.|..|....:.|..|:.:|..:.||||
Mouse  1986 VHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGG 2050

  Fly  1272 TKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSK 1335
            .|||::.|:| .|...::.||||:.|:||.:||.:|.....:.::|::|:||||:|:|..|||::
Mouse  2051 NKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTR 2115

  Fly  1336 SVILVDGSIYAMGSVQHVKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYE 1399
            ..|:|:|....:|||||:||:...|.|:.: :....||     |..:::...:.:|.:.||||:.
Mouse  2116 MAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPD-----LKPVQEFFGLAFPGSVLKEKHR 2175

  Fly  1400 FSGRLTFQI-SKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
              ..|.:|: |..:|.:.||..:..::...|:||||:||.:|:..|...|:::
Mouse  2176 --NMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42816NP_730301.3 rim_protein <81..1451 CDD:130324 441/1670 (26%)
Abca1XP_006537617.1 rim_protein 6..2238 CDD:130324 454/1743 (26%)

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