DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42816 and Abca1

DIOPT Version :9

Sequence 1:NP_730301.3 Gene:CG42816 / 39977 FlyBaseID:FBgn0261998 Length:1459 Species:Drosophila melanogaster
Sequence 2:XP_006537617.1 Gene:Abca1 / 11303 MGIID:99607 Length:2263 Species:Mus musculus


Alignment Length:1737 Identity:453/1737 - (26%)
Similarity:777/1737 - (44%) Gaps:401/1737 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSP----PIFKSDNSSTLQDVGIMIIVII 74
            ||..:|..:.|..|:.......||.     ..::.:|.|    .||....|.::.    :.:.:.
Mouse   592 GFAYLQDVVEQAIIRVLTGSEKKTG-----VYVQQMPYPCYVDDIFLRVMSRSMP----LFMTLA 647

  Fly    75 IFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKLVLPNSE 139
            ..:.|..:.||||.|||.:||.|:.:||:.:.:.|.:|::.:.|..|:.:.::.:..||.     
Mouse   648 WIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLG----- 707

  Fly   140 ISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSE 204
             :.:|::..|:....|.|.:..||...||:|:|.|.....:....:.....|||:::..:.....
Mouse   708 -NLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYV 771

  Fly   205 GLNVFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILAS 263
            |.::.:...|||      |.:.    ..::|:.|.|:||.||||:.......::...:.:|:..:
Mouse   772 GFSIKIFASLLSPVAFGFGCEY----FALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDT 832

  Fly   264 FLSLLLCLYLEKIRPGPYGVPQPWHFPCTRC-CSTESLLPYSRLFNRIFGIYSAAPDEERPDLQL 327
            ||..::..|:|.:.||.||:|:||:||||:. ...|.:...|...:...|:.....:||...|:|
Mouse   833 FLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEEPTHLRL 897

  Fly   328 IEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISP 390
                      ||.|:.|.|.:  |....|..::.:.:|||||..:|||||||||.:|:|.|...|
Mouse   898 ----------GVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPP 952

  Fly   391 TSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLK 455
            |||||.|.|.|||.|....::.:|:|||.||||..|:...||..::||:||....||:|::....
Mouse   953 TSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMAL 1017

  Fly   456 KLNLQEKK-RLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGC 519
            .:.|...| :.....||||.||:||||.:..||.||:|.|||:.|:||.:||.:|.|:|:.::|.
Mouse  1018 DVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGR 1082

  Fly   520 TILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV---------------------DASC 563
            ||:|:||.:|:.::||||:.|||.|:|.|:||..|||.|:                     ::|.
Mouse  1083 TIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSS 1147

  Fly   564 LITC-------------------EARKRC----DLEKLTSLISRHVGTIQPFSIKGRDVCYKLPL 605
            .::|                   |.::..    |:..:::||.:||...:.....|.::.|.||.
Mouse  1148 TVSCLKKVVPGLPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPY 1212

  Fly   606 SKSK--YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAED-LNSRQSGG----------- 656
            ..:|  .|..||.:::.:::.||:..:.:|..:|||||:....|. :::..|.|           
Mouse  1213 EAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAF 1277

  Fly   657 AEKR------------DDDDRDDDEENEV------QDGNVRSCKKQWR-------AMMTKKVMAL 696
            .:|:            |.:|.|.|.|:..      .||......|.|:       |::.|:::..
Mouse  1278 GDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIA 1342

  Fly   697 YDNKVYFLLLLLTPIVYYITTLMMA---------------------------------------- 721
            ..::..|...::.|.|:....|:.:                                        
Mouse  1343 RRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELL 1407

  Fly   722 ---TK------------------------------------------------------------ 723
               ||                                                            
Mouse  1408 NALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKI 1472

  Fly   724 --------PHHSGRPT----------------FNISDYGVDKFTILLSVPV-SKSYTEERR---- 759
                    |...|.|.                .|||||.|..:..:::..: :|.:..|.|    
Mouse  1473 KKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGF 1537

  Fly   760 ------------ADSIASLIKGKLKLIVVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGL 812
                        :..:...||...||:.::   ||...|::.|..||    |:: .:||.:...:
Mouse  1538 SLGVSNSQALPPSHEVNDAIKQMKKLLKLT---KDSSADRFLSSLGR----FMA-GLDTKNNVKV 1594

  Fly   813 IGWVGPRHYVHAAPMILNLVYNAL----AQELIGP-KISIEVTSVPFTLRKK---EDFLISNNGD 869
              |...:.: ||....||::.||:    .|:...| :..|...:.|..|.|:   |..|::.:.|
Mouse  1595 --WFNNKGW-HAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVD 1656

  Fly   870 I-----PIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM--------- 920
            :     .|:.:.:|..:.::|   :||||||..|.||.:||::.:.||||:..:||         
Mouse  1657 VLVSICVIFAMSFVPASFVVF---LIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATL 1718

  Fly   921 -VVFFIL-------------VLALLLPLYGYAPWYLLLCVLFFTGLAGLIF-IYFLISMLSATFL 970
             ::.||.             ||||||.|||::             :..|:: ..|:..:.|..::
Mouse  1719 VIIIFICFQQKSYVSSTNLPVLALLLLLYGWS-------------ITPLMYPASFVFKIPSTAYV 1770

  Fly   971 AVSMILLSV-IIGSLILMI--------LGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMS 1026
            .::.:.|.: |.||:...:        |..:..|.|.|:          ||..:.|:.:....| 
Mouse  1771 VLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVF----------LIFPHFCLGRGLIDM- 1824

  Fly  1027 LCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DMLVMLGTAIILFLLIM 1087
            :....:::|.....||.                   .|:|::|.    ::..|....::.||:.:
Mouse  1825 VKNQAMADALERFGENR-------------------FVSPLSWDLVGRNLFAMAVEGVVFFLITV 1870

  Fly  1088 FFEYGSCVWYRCKGCCPYSSK---GSIEDPKVSREAEKIRAMDADQIGTR-ALVVNGVSKKYGCD 1148
            ..:|...:..|     |..:|   .:.||..|.||.::|    .|..|.. .|.:..::|.|...
Mouse  1871 LIQYRFFIRPR-----PVKAKLPPLNDEDEDVRRERQRI----LDGGGQNDILEIKELTKIYRRK 1926

  Fly  1149 QL-AVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELG 1212
            :. ||:.|...:.|..|.||||.|||||:|||||:.|:..:.:|:.:::..|:....::..:.:|
Mouse  1927 RKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMG 1991

  Fly  1213 YCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKIN 1277
            ||||.|:..|.||||:.::.|.|:.|.|.|::.|..|....:.|..|:.:|..:.||||.|||::
Mouse  1992 YCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLS 2056

  Fly  1278 AAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVD 1341
            .|:| .|...::.||||:.|:||.:||.:|.....:.::|::|:||||:|:|..|||::..|:|:
Mouse  2057 TAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVN 2121

  Fly  1342 GSIYAMGSVQHVKNKIAKGMTLKL-VVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLT 1405
            |....:|||||:||:...|.|:.: :....||     |..:::...:.:|.:.||||:.  ..|.
Mouse  2122 GRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPD-----LKPVQEFFGLAFPGSVLKEKHR--NMLQ 2179

  Fly  1406 FQI-SKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            :|: |..:|.:.||..:..::...|:||||:||.:|:..|...|:::
Mouse  2180 YQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQ 2226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42816NP_730301.3 CcmA 336..643 CDD:224054 129/355 (36%)
ABC_subfamily_A 339..556 CDD:213230 101/219 (46%)
ABC2_membrane_3 <821..1018 CDD:289468 59/242 (24%)
CcmA 1135..1450 CDD:224054 113/318 (36%)
ABC_subfamily_A 1136..1354 CDD:213230 85/219 (39%)
Abca1XP_006537617.1 rim_protein 6..2238 CDD:130324 453/1737 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 159 1.000 Domainoid score I4067
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.730

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