DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and ABCA8

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	NP_001275914.1	Gene:	ABCA8 / 10351	HGNCID:	38	Length:	1621	Species:	Homo sapiens

Alignment Length:	1576	Identity:	381/1576 - (24%)
Similarity:	690/1576 - (43%)	Gaps:	285/1576 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YKTGFLAVQQALS----QVHIKHKCKE--FNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIM 69
            :|.||:|:|.|::    ::...|...|  .:.|..::|....          ...|..:.|:.:.
Human   173 WKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSF----------IGQSGVITDLYLF 227

  Fly    70 IIVI----IIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAW-YIQTFIIFLIGSSIITL 129
            ..:|    .|::..|::|:   |.|  ::|..:.:||:.....|::| .:....||     |:.|
Human   228 SCIISFSSFIYYASVNVTR---ERK--RMKALMTMMGLRDSAFWLSWGLLYAGFIF-----IMAL 282

  Fly   130 FWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIA-TYLP 193
            |..||:.:::...:.......:||:|..||  .:..:||||.|:..::...||.||..:. ..|.
Human   283 FLALVIRSTQFIILSGFMVVFSLFLLYGLS--LVALAFLMSILVKKSFLTGLVVFLLTVFWGCLG 345

  Fly   194 FLILHSKGCSEGLNVFLSL-----FLLSGLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVG 253
            |..|: :.....|...|||     |:|...|:|.:      ||       :|...::|..:....
Human   346 FTSLY-RHLPASLEWILSLLSPFAFMLGMAQLLHL------DY-------DLNSNAFPHPSDGSN 396

  Fly   254 YILLVMILASF---LSLLLCLYLEKIRPGPYGVPQP---------W-HFPCTRCCSTESLLPYSR 305
            .|:....:.:|   |.|.|.:|.|||.|..||..:|         | ....|...:.|..:....
Human   397 LIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADP 461

  Fly   306 LFNRIFGIYSAAPDEERPDLQLIEPDPVDKIAGVQIRGLSKTF----GKMEVVKNVSFDMFEGQI 366
            .|:..|       ::..|:.|..|        .::||.::|.:    .|:|.:|::.||::||||
Human   462 SFHDSF-------EQAPPEFQGKE--------AIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQI 511

  Fly   367 TVLMGHNGAGKTTLISMLAGFISPTSGTALI--NGFDIRQERRQAQRCIGLCPQQNVLFKHLSSV 429
            |.::||:||||:||:::|:|...||.|:..|  |......:.....:..|:|||.||.|..|:..
Human   512 TAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVR 576

  Fly   430 SHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICD 494
            .:::||::::|:...||..|:|..|.:|.::..:.:.|:|||||.:|:|:...::.|..::.:.|
Human   577 ENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLD 641

  Fly   495 EPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQV 559
            ||:.||||.:|.::|.|:.|.|....||.:|..:|:.::|.||.|.:|.|:|:|.||..||||:.
Human   642 EPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKW 706

  Fly   560 DASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFRDLESQMNI 624
            .....::.:..:.|..|.:|||:.:|:...:..:.....:.|.|||.::..|..|::||:|..:
Human   707 GIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDLDSYPD- 770

  Fly   625 LGVRGFSLSSVSLEEIFMSF-GAEDLNSRQSG-----GAEKRDDDDRDDDEENEVQD-------- 675
            ||:..:.:|..:|.|:|:.. |...:|.....     .|||.||.:|..:.|..:..
Human   771 LGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQAEKADDTERLVEMEQVLSSLNKMRKTI 835

  Fly   676 GNVRSCKKQWRAMMTKKVMALYDNKVYFLLLLLTPIVYYITTLMMATKPHHSGRPTFNISDYGVD 740
            |.|...::|..|:...:::.|...:...|.|||..:..:...|:                :|.:.
Human   836 GGVALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLV----------------EYTMV 884

  Fly   741 KFTILLSVPVSKSYTEERRADSIASLIKGK-----LKLIVVSEQIKDYVDDKWKSREGRREINFV 800
            |.       ...|||.| .:..:..|..|:     |..:::..:....:||..:|.|.:.    :
Human   885 KI-------YQNSYTWE-LSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFIQSVEHQN----I 937

  Fly   801 SMAIDT-GDRTG---------LIGWVGPRHY----------VHAAPMILNLVYNALAQELIGPKI 845
            ::.:|. |.|.|         :......::|          ::..|:::::|.|.|. .::.|.:
Human   938 ALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIVSNGLL-GMVKPSV 1001

  Fly   846 SIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSS-------AVIQERVSHMKMLQEV 903
            .|         |.:....:.|..|.||..:.|:...:::.||       :.|.:..:..:....:
Human  1002 HI---------RTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRI 1057

  Fly   904 SGLEMITYWLSHLAFDMVVFFILVLALLLPLYGYAPWYLLLCVLFFTGLAGLIFIYFLISMLSAT 968
            |||....||......|:.::|::.:.:          ||:..:..|..:  |:.|..:|.:..|.
Human  1058 SGLSPSAYWFGQALVDVSLYFLVFVFI----------YLMSYISNFEDM--LLTIIHIIQIPCAV 1110

  Fly   969 FLAVSMILLSVIIGSL-------------------ILMILGALALIFKMVYVAIYVANMHPLIAG 1014
            ..:.|:|.::.:|..:                   :..:.|....||:.....|:...:.|...
Human  1111 GYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATM- 1174

  Fly  1015 YNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINP-LAFLEPRCVCVNPMTWPDMLVMLGT 1078
            ..|:....|.              |..:|.|:|...:.| |.||.|
Human  1175 IGCLFLSSHL--------------LFSSLFSEERMDVQPFLVFLIP------------------- 1206

  Fly  1079 AIILFLLIMFFEYGSCVWY----------------RCKGCC--PYSSKGSIEDPKVSREAEKIRA 1125
              .|..:|..|......|.                |....|  |...:|..||.::.| .....|
Human  1207 --FLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQMER-VRTANA 1268

  Fly  1126 MDADQIGTRALVVNG------VSKKYGC-----DQLAVNNISFALKPSHCVGLLGPNGAGKTTTF 1179
            :::.....:.:::..      ..|:.||     :::|..|:||.::....:||||.|||||:|:.
Human  1269 LNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSI 1333

  Fly  1180 KMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDL 1244
            |:|.|:.....|.:.:.|..    ...|::.||||||.::.:..||.||.|:|:..:.|....|.
Human  1334 KVITGDTKPTAGQVLLKGSG----GGDALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDA 1394

  Fly  1245 NKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTI 1308
            .....:|.|....:..|...:...|.|.|||:...:: .|..|::.|||||.|:||..::.:|..
Human  1395 EVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQA 1459

  Fly  1309 INEVAQQ-GKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHVKNKIAKGMTLKLVVNVQPD 1372
            |....:. .:..|||:|.|.|..|:|.:..|:|.|.:..:||:||:|:|..|...|::.|
Human  1460 IRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKV----- 1519

  Fly  1373 NMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKD--TSWSEIFEYVEGNRSSWHLEDYSL 1435
            ..:|.:..:..:|...:|.|..:|:|  |..:.:::..:  ...::.|..:|..:.|:.||:|||
Human  1520 KNLAQVEPLHAEILRLFPQAARQERY--SSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLEEYSL 1582

  Fly  1436 SQPSLEDAFEEIAEER 1451
            ||.:||..|.|:::|:
Human  1583 SQSTLEQVFLELSKEQ 1598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	105/312 (34%)
		ABC_subfamily_A	339..556	CDD:213230	81/222 (36%)
		ABC2_membrane_3	<821..1018	CDD:289468	38/232 (16%)
		CcmA	1135..1450	CDD:224054	98/329 (30%)
		ABC_subfamily_A	1136..1354	CDD:213230	72/230 (31%)
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324	172/596 (29%)
		ABC_subfamily_A	480..703	CDD:213230	81/222 (36%)
		rim_protein	<1033..1598	CDD:130324	146/624 (23%)
		ABC_subfamily_A	1285..1506	CDD:213230	72/224 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720