DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42816 and ABCA9

DIOPT Version :9

Sequence 1:NP_730301.3 Gene:CG42816 / 39977 FlyBaseID:FBgn0261998 Length:1459 Species:Drosophila melanogaster
Sequence 2:XP_024306297.1 Gene:ABCA9 / 10350 HGNCID:39 Length:1634 Species:Homo sapiens


Alignment Length:1608 Identity:406/1608 - (25%)
Similarity:703/1608 - (43%) Gaps:336/1608 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 DGSYPLYKTGFLAVQQALS----QVHIKHKCKE--FNKTQGDIKFPPIKDLPSPPIFKSDNSSTL 63
            :|| ..::.||:|.|.|::    ::...|...|  .:.|...:|..|         |.:.     
Human   177 EGS-EFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVHMKILP---------FVAQ----- 226

  Fly    64 QDVGIMIIVIIIFFVVVSLTKSI------VEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLI 122
               |.:.....|||.::|.:..|      |.::...:...:.:||:.....|::|.:......||
Human   227 ---GGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLSWGLMYAGFILI 288

  Fly   123 GSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLAL 187
            .::::.    |::.:::|..:........||:|..||..|:  :||||.||...:...||.||.:
Human   289 MATLMA----LIVKSAQIVVLTGFVMVFTLFLLYGLSLITL--AFLMSVLIKKPFLTGLVVFLLI 347

  Fly   188 IA-TYLPFLILHSKGCSEGLNVFL--SLFLLSGLQVLVVGIC--MWEDYGEGLQWGNLFETSWPG 247
            :. ..|.|..|:::     |..||  :|.|||.. ...||:.  :..||...   .|....|...
Human   348 VFWGILGFPALYTR-----LPAFLEWTLCLLSPF-AFTVGMAQLIHLDYDVN---SNAHLDSSQN 403

  Fly   248 GTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLF----- 307
            ..|.:. .|.:::..:.|.|:|.||.:||.|..||     |    ||         |.||     
Human   404 PYLIIA-TLFMLVFDTLLYLVLTLYFDKILPAEYG-----H----RC---------SPLFFLKSC 449

  Fly   308 --------NRIFGIYSAAPDEERPD--LQLIEPDPVDKIAGVQIRGLSKTFG----KMEVVKNVS 358
                    |.:. :.:....:..|:  .:.:.|:...|.| ::|:.|.|.:.    ::|.:|.|.
Human   450 FWFQHGRANHVV-LENETDSDPTPNDCFEPVSPEFCGKEA-IRIKNLKKEYAGKCERVEALKGVV 512

  Fly   359 FDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQ--ERRQAQRCIGLCPQQNV 421
            ||::|||||.|:||:|||||||:::|:|...||||:..:....:.:  :.....:..|.|||.||
Human   513 FDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNV 577

  Fly   422 LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCG 486
            .|..|:...:::||::::|:...||:.|||..:::|.::..:.:.|:|||||..|:|:...::.|
Human   578 QFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFGIAILG 642

  Fly   487 GVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGS 551
            ..:||:.|||:.||||.:|..:|.|:.|.|....||.:|..:|:.::|.||.|.||:|:|:|.||
Human   643 DPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFISNGKLKCAGS 707

  Fly   552 LPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYFSSLFR 616
            ..||||:......::....:|||.|.:|||:.:|:...:..:.....:.|.|||.::..|..|:|
Human   708 SLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYR 772

  Fly   617 DLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRDDDEENEVQDGNVRSC 681
            ||:...| .|:..:.:|..:|.|:|:....:........|...:...|...|..:.|:...|.|.
Human   773 DLDRCSN-QGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQTDGAKDIGSLVELEQVLSS 836

  Fly   682 KKQWR------AMMTKKVMALYDNKVYFLLL----------LLTPIVYYITTLM--------MAT 722
            ..:.|      |:..::|.|:  .||.||.|          ||...:.:|..|:        ..:
Human   837 FHETRKTISGVALWRQQVCAI--AKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFYESYQKS 899

  Fly   723 KPHHSGRPTFNIS--DYGVDKFTILLSVPVSKSYTEERRADSIASLIKGKLKLIVVSEQIKDYVD 785
            .|......|:.:|  ....|..|.||.:..:.|..:    :.:.||.:..:.:.|          
Human   900 YPWELSPNTYFLSPGQQPQDPLTHLLVINKTGSTID----NFLHSLRRQNIAIEV---------- 950

  Fly   786 DKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHYVHAA---------PMILNLVYNALAQELI 841
            |.:.:|.|..:.::....|.:||...        |....|         |::|:::.|.    |:
Human   951 DAFGTRNGTDDPSYNGAIIVSGDEKD--------HRFSIACNTKRLNCFPVLLDVISNG----LL 1003

  Fly   842 GPKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVS-----IAM-------IIFSSAVIQERV 894
            |...|.|      .::.........:.|   |..||.|     |.|       |..||....::.
Human  1004 GIFNSSE------HIQTDRSTFFEEHMD---YEYGYRSNTFFWIPMAASFTPYIAMSSIGDYKKK 1059

  Fly   895 SHMKMLQEVSGLEMITYWLSHLAFDMVVFFILVLALLLPLYGYAP-------WYLLLCVLFFTG- 951
            :|.::  .:|||....||......|:.::|:::|.:.:..|.::|       ..||:.:|...| 
Human  1060 AHSQL--RISGLYPSAYWFGQALVDVSLYFLILLLMQIMDYIFSPEEIIFIIQNLLIQILCSIGY 1122

  Fly   952 LAGLIFIYFLISML-----------SATFLAVSMI-----------LLSVIIGSLIL---MILGA 991
            ::.|:|:.::||.:           |..||.|.:.           .|.:..|::::   .::|:
Human  1123 VSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGTMLIPPFTLIGS 1187

  Fly   992 LALIF----------------KMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLS 1040
            | .||                ::||:|:.:..:|.||  :..|.:|.                  
Human  1188 L-FIFSEISPDSMDYLGASESEIVYLALLIPYLHFLI--FLFILRCL------------------ 1231

  Fly  1041 ENLTSDEMYC------INPLAFLEPRCVCVNPMTWPDMLVMLGTAIILFLLIMFFEYGSCVWYRC 1099
                  ||.|      .:|:..:.||...:.|.                                
Human  1232 ------EMNCRKKLMRKDPVFRISPRSNAIFPN-------------------------------- 1258

  Fly  1100 KGCCPYSSKGSIEDPKVSREAEKIRAM---DADQIGTRALVVNGVSKKY-----GC-----DQLA 1151
                |...:|..||.::.| ...:.||   |.|:  |..::.:.:.|:|     .|     .::|
Human  1259 ----PEEPEGEEEDIQMER-MRTVNAMAVRDFDE--TPVIIASCLRKEYAGKKKNCFSKRKKKIA 1316

  Fly  1152 VNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQ 1216
            ..|:||.:|....:||||.|||||:||.|||.|:.....|.:.:.|..    ..:.:..||||||
Human  1317 TRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSG----GGEPLGFLGYCPQ 1377

  Fly  1217 SDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA 1281
            .::.:..||.||.|:|:..:.|....|......:|.|....:..|...:...|.|.|||:...::
Human  1378 ENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLS 1442

  Fly  1282 -CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQ-GKAVLLTSHNMDEINALCSKSVILVDGSI 1344
             .|..|::.|||||.|:||..::.:|.:|....:. .:..|||:|.|.|..|:|.:..|:|.|.:
Human  1443 ILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRL 1507

  Fly  1345 YAMGSVQHVKNKIAKG----MTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLT 1405
            ..:||:||:|:|..|.    |.||.:..::|         :..:|...:|.|..:|:  ||..:.
Human  1508 RCIGSIQHLKSKFGKDYLLEMKLKNLAQMEP---------LHAEILRLFPQAAQQER--FSSLMV 1561

  Fly  1406 FQISKD--TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEER 1451
            :::..:  ...|:.|..:|..:.|:.||:|||||.:||..|.|:::|:
Human  1562 YKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQ 1609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42816NP_730301.3 CcmA 336..643 CDD:224054 112/312 (36%)
ABC_subfamily_A 339..556 CDD:213230 85/222 (38%)
ABC2_membrane_3 <821..1018 CDD:289468 53/266 (20%)
CcmA 1135..1450 CDD:224054 102/332 (31%)
ABC_subfamily_A 1136..1354 CDD:213230 74/229 (32%)
ABCA9XP_024306297.1 ABC2_membrane_3 53..416 CDD:315386 62/272 (23%)
AAA <245..1609 CDD:333001 387/1520 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.720

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