Protein Alignment CG42816 and ABCA7

DIOPT Version :10

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Alignment Length: 1667
• Identity: 428/1667 - (25%)
• Similarity: 728/1667 - (43%)
• Gaps: 351/1667 - (21%)

  Fly    53 PIFKSDNSSTLQDVGIMIIVIIIFFVVVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQT 116
            |.:..|....:....:.:.:.:.:...|:|| |::|.|||.:|:.|:..||:...:.|:.|::..
Human   535 PCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSC 599

  Fly   117 FIIFLIGSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISL 181
            ...||:.::::.|..||.      ..:|::|..:....|...:..|:..|||:|:..|.....:.
Human   600 LGPFLLSAALLVLVLKLG------DILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAA 658

  Fly   182 VTFLALIATYLPFLILHSKGC-------SEGLNVFLSLFLLSGLQVLVVG-----ICMWEDYGEG 234
            ...||..:.|||:::     |       ..|..|..||     |..:..|     :.:.|:.|||
Human   659 CGGLAYFSLYLPYVL-----CVAWRDRLPAGGRVAASL-----LSPVAFGFGCESLALLEEQGEG 713

  Fly   235 LQWGNLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTES 299
            .||.|: .|.......|:..:..:::|.:.|..|...|||.:.||.||:|:||:||
Human   714 AQWHNV-GTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFP--------- 768

  Fly   300 LLPYSRLFNRIFGIYSAAPDEERP------DLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKN 356
                   |.|.:......|....|      ...|:|..|.....||.:|.|.|.|  .....::.
Human   769 -------FRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRG 826

  Fly   357 VSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNV 421
            :|.|.::|.||..:|||||||||.:|:|:|...|:.|:|.|.|.|:|......:..:|:|||.||
Human   827 LSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNV 891

  Fly   422 LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCG 486
            ||..|:...|:..:.||:||..|.|..|....|:.:.|..|:.:..|:||||.||:||||.:..|
Human   892 LFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVG 956

  Fly   487 GVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGS 551
            |.:|:|.|||:.|:||::||.:|.|:|:.:||.|::|:||.||:.|:|||||.:::.|:|.|.||
Human   957 GSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGS 1021

  Fly   552 LPFLKKQVDASCLIT-CEAR------KRCDLEKLTSLISR----------HVGTIQPFS-----I 594
            ..||::.:.:...:| .:||      ::.|.:...|:.:|          .|||.|..:     :
Human  1022 PLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWV 1086

  Fly   595 KGRDVCYKLPL----------SKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSF----- 644
            .|..:..:||.          :....|::|||:|::::..|.:.|:.:|..||||||:..
Human  1087 PGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECA 1151

  Fly   645 ---GAED----------------------------LNSRQSGGAEKRDDDDRDDDEENEVQDGNV 678
               ..||                            |.:.:..|:....|.....|....||...:
Human  1152 ADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWAL 1216

  Fly   679 RSCKKQWRAMMTKKVM----------------ALYDNKVYFLLLLLTPIVYYITTLMMAT----- 722
              .::|.:|::.|:.:                ||:........|::.|..:|....:..|
Human  1217 --TRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQ 1279

  Fly   723 -------KPHHSGRPTF---NISDYGVDKFTI---------------LLSVPVSKSYTEERRADS 762
                   .|...||...   .:.:.|:::..:               :..|..|.::|.|..:.:
Human  1280 VSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPA 1344

  Fly   763 IASLIKGKLKLI-------------------------VVSEQIKDY--------VDDKWKSREGR 794
            ......|..:|:                         :....:.|:        |....|:::..
Human  1345 CQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWV 1409

  Fly   795 REINFVSMAI---DTG--------------------------DRT--GLIGWVGPRHYV------ 822
            .|:.:...::   |.|                          ||.  .|..|.   |.:
Human  1410 NEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWA---HSLDAQDSL 1471

  Fly   823 ---------HAAPMILNLVYNALAQELIGP-----KISIEVTSVPFTLRKK---EDFLISNNGD- 869
                     |:....:|...||:.:..:.|     ..||...:.|..|.|:   |..|::::.|
Human  1472 KIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDV 1536

  Fly   870 -IPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFI---LVLAL 930
             :.|.|:..:|.....|:..:|:|||:..|.||.:.||....|||.:..:||..:.:   :|:.:
Human  1537 LVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLI 1601

  Fly   931 LLPLYGYA-------PWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAVSMILLSV-IIGSLIL 986
            .|.....|       |..|||.:|:...:..|:: ..|..|:.|..::.::.|.|.: |.||:..
Human  1602 FLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMAT 1666

  Fly   987 MI--------LGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENL 1043
            .:        |..::.|.|.|:          ||..:.|:.:     .|.....::|.....|.|
Human  1667 FVLELFSDQKLQEVSRILKQVF----------LIFPHFCLGR-----GLIDMVRNQAMADAFERL 1716

  Fly  1044 TSDEMYCINPLAFLEPRCVCVNPMTW----PDMLVML--GTAIILFLLIMFFEYGSCVWYRCKGC 1102
             .|..:              .:|:.|    .::|.|:  |...:||.|::        .:|.: .
Human  1717 -GDRQF--------------QSPLRWEVVGKNLLAMVIQGPLFLLFTLLL--------QHRSQ-L 1757

  Fly  1103 CPYSSKGSI-----EDPKVSREAEKI--RAMDADQIGTRALVVNGVSKKY-GCDQLAVNNISFAL 1159
            .|.....|:     ||..|:||.|::  .|...|     .||:..::|.| |....||:.:...:
Human  1758 LPQPRVRSLPLLGEEDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMPAVDRLCLGI 1817

  Fly  1160 KPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFL 1224
            .|..|.||||.||||||:||:|:.|:....:|...::|:|:..:.:.|...:|||||||:.||.|
Human  1818 PPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882

  Fly  1225 TGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLI 1288
            |||:.|::...:.|.|...:.:.......:.|...:.|:....||||.|||:..|:| .|..:::
Human  1883 TGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVV 1947

  Fly  1289 CLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHV 1353
            .||||:.|:||::||.:|..:..|.::|::|:||||:|:|..||||:..|:|:|....:||.||:
Human  1948 FLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHL 2012

  Fly  1354 KNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKD--TSWSE 1416
            |.:.|.|.||.|.|........|.....|      :|.|||:|.:  .|||.||:...  .:.:.
Human  2013 KGRFAAGHTLTLRVPAARSQPAAAFVAAE------FPGAELREAH--GGRLRFQLPPGGRCALAR 2069

  Fly  1417 IFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKSNQ 1458
            :|..:..:.:...:||:|:||..||:.|...::::.|.:..:
Human  2070 VFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTE 2111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	424/1630 (26%)
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	428/1663 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		1/8 (13%)