DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42816 and ABCA7

DIOPT Version :9

Sequence 1:NP_730301.3 Gene:CG42816 / 39977 FlyBaseID:FBgn0261998 Length:1459 Species:Drosophila melanogaster
Sequence 2:XP_024307083.1 Gene:ABCA7 / 10347 HGNCID:37 Length:2151 Species:Homo sapiens


Alignment Length:1672 Identity:429/1672 - (25%)
Similarity:728/1672 - (43%) Gaps:356/1672 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 PIFKSDNSSTLQDVGIMIIVIIIFFVVVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQT 116
            |.:..|....:....:.:.:.:.:...|:|| |::|.|||.:|:.|:..||:...:.|:.|::..
Human   535 PCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSC 599

  Fly   117 FIIFLIGSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISL 181
            ...||:.::::.|..||.      ..:|::|..:....|...:..|:..|||:|:..|.....:.
Human   600 LGPFLLSAALLVLVLKLG------DILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAA 658

  Fly   182 VTFLALIATYLPFLILHSKGC-------SEGLNVFLSLFLLSGLQVLVVG-----ICMWEDYGEG 234
            ...||..:.|||:::     |       ..|..|..||     |..:..|     :.:.|:.|||
Human   659 CGGLAYFSLYLPYVL-----CVAWRDRLPAGGRVAASL-----LSPVAFGFGCESLALLEEQGEG 713

  Fly   235 LQWGNLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTES 299
            .||.|: .|.......|:..:..:::|.:.|..|...|||.:.||.||:|:||:||         
Human   714 AQWHNV-GTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFP--------- 768

  Fly   300 LLPYSRLFNRIFGIYSAAPDEERP------DLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKN 356
                   |.|.:......|....|      ...|:|..|.....||.:|.|.|.|  .....::.
Human   769 -------FRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRG 826

  Fly   357 VSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNV 421
            :|.|.::|.||..:|||||||||.:|:|:|...|:.|:|.|.|.|:|......:..:|:|||.||
Human   827 LSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNV 891

  Fly   422 LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCG 486
            ||..|:...|:..:.||:||..|.|..|....|:.:.|..|:.:..|:||||.||:||||.:..|
Human   892 LFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVG 956

  Fly   487 GVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGS 551
            |.:|:|.|||:.|:||::||.:|.|:|:.:||.|::|:||.||:.|:|||||.:::.|:|.|.||
Human   957 GSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGS 1021

  Fly   552 LPFLKKQVDASCLIT-CEAR------KRCDLEKLTSLISR----------HVGTIQPFS-----I 594
            ..||::.:.:...:| .:||      ::.|.:...|:.:|          .|||.|..:     :
Human  1022 PLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWV 1086

  Fly   595 KGRDVCYKLPL----------SKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSF----- 644
            .|..:..:||.          :....|::|||:|::::..|.:.|:.:|..||||||:..     
Human  1087 PGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECA 1151

  Fly   645 ---GAED----------------------------LNSRQSGGAEKRDDDDRDDDEENEVQDGNV 678
               ..||                            |.:.:..|:....|.....|....||...:
Human  1152 ADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWAL 1216

  Fly   679 RSCKKQWRAMMTKKVM----------------ALYDNKVYFLLLLLTPIVYYITTLMMAT----- 722
              .::|.:|::.|:.:                ||:........|::.|..:|....:..|     
Human  1217 --TRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQ 1279

  Fly   723 -------KPHHSGRPTF---NISDYGVDKFTI---------------LLSVPVSKSYTEERRADS 762
                   .|...||...   .:.:.|:::..:               :..|..|.::|.|..:.:
Human  1280 VSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPA 1344

  Fly   763 IASLIKGKLKLI-------------------------VVSEQIKDY--------VDDKWKSREGR 794
            ......|..:|:                         :....:.|:        |....|:::..
Human  1345 CQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWV 1409

  Fly   795 REINFVSMAI---DTG--------------------------DRT--GLIGWVGPRHYV------ 822
            .|:.:...::   |.|                          ||.  .|..|.   |.:      
Human  1410 NEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWA---HSLDAQDSL 1471

  Fly   823 ---------HAAPMILNLVYNALAQELIGP-----KISIEVTSVPFTLRKK---EDFLISNNGD- 869
                     |:....:|...||:.:..:.|     ..||...:.|..|.|:   |..|::::.| 
Human  1472 KIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDV 1536

  Fly   870 -IPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFI---LVLAL 930
             :.|.|:..:|.....|:..:|:|||:..|.||.:.||....|||.:..:||..:.:   :|:.:
Human  1537 LVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLI 1601

  Fly   931 LLPLYGYA-------PWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAVSMILLSV-IIGSLIL 986
            .|.....|       |..|||.:|:...:..|:: ..|..|:.|..::.::.|.|.: |.||:..
Human  1602 FLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMAT 1666

  Fly   987 MI--------LGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENL 1043
            .:        |..::.|.|.|:          ||..:.|:.:     .|.....::|.....|.|
Human  1667 FVLELFSDQKLQEVSRILKQVF----------LIFPHFCLGR-----GLIDMVRNQAMADAFERL 1716

  Fly  1044 TSDEMYCINPLAFLEPRCVCVNPMTW----PDMLVML--GTAIILFLLIMFFEYGSCVWYRCKGC 1102
             .|..:              .:|:.|    .::|.|:  |...:||.|::        .:|.:..
Human  1717 -GDRQF--------------QSPLRWEVVGKNLLAMVIQGPLFLLFTLLL--------QHRSQLL 1758

  Fly  1103 CPYSSK----------GSIEDPKVSREAEKI--RAMDADQIGTRALVVNGVSKKY-GCDQLAVNN 1154
            ..||..          |. ||..|:||.|::  .|...|     .||:..::|.| |....||:.
Human  1759 PQYSVPRPRVRSLPLLGE-EDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMPAVDR 1817

  Fly  1155 ISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDS 1219
            :...:.|..|.||||.||||||:||:|:.|:....:|...::|:|:..:.:.|...:|||||||:
Human  1818 LCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDA 1882

  Fly  1220 FFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CG 1283
            .||.||||:.|::...:.|.|...:.:.......:.|...:.|:....||||.|||:..|:| .|
Human  1883 IFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVG 1947

  Fly  1284 ANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMG 1348
            ..:::.||||:.|:||::||.:|..:..|.::|::|:||||:|:|..||||:..|:|:|....:|
Human  1948 DPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLG 2012

  Fly  1349 SVQHVKNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKD-- 1411
            |.||:|.:.|.|.||.|.|........|.....|      :|.|||:|.:  .|||.||:...  
Human  2013 SPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAE------FPGAELREAH--GGRLRFQLPPGGR 2069

  Fly  1412 TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKSNQ 1458
            .:.:.:|..:..:.:...:||:|:||..||:.|...::::.|.:..:
Human  2070 CALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTE 2116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42816NP_730301.3 CcmA 336..643 CDD:224054 124/340 (36%)
ABC_subfamily_A 339..556 CDD:213230 95/218 (44%)
ABC2_membrane_3 <821..1018 CDD:289468 54/241 (22%)
CcmA 1135..1450 CDD:224054 113/318 (36%)
ABC_subfamily_A 1136..1354 CDD:213230 85/219 (39%)
ABCA7XP_024307083.1 rim_protein 1..2114 CDD:130324 429/1668 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.730

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