DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42816 and LOC101883122

DIOPT Version :9

Sequence 1:	NP_730301.3	Gene:	CG42816 / 39977	FlyBaseID:	FBgn0261998	Length:	1459	Species:	Drosophila melanogaster
Sequence 2:	XP_021333309.1	Gene:	LOC101883122 / 101883122	-ID:	-	Length:	2391	Species:	Danio rerio

Alignment Length:	1915	Identity:	398/1915 - (20%)
Similarity:	661/1915 - (34%)	Gaps:	725/1915 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GFLAVQQALSQVHIKHKCKEFNKTQGDIKFPPIKDLPSPPIFKSDNSSTLQDVGIMIIVIIIFFV 78
            ||:.:|..:.:..||.: ....:|.|..    .:.:|.|........|.:..:..|.:|:...:.
Zfish   520 GFVYLQDMVDRAIIKLQ-TGVQQTLGVY----AQQMPYPCYMDDAFVSAIGTMLPMFLVLAFNYS 579

  Fly    79 VVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKL--VLPNSEIS 141
            |..:.|.:|.|||.:||..|.:.||.:....:.|:.:..|:.::..::|::..|.  ||..|:.|
Zfish   580 VSEIIKGLVLEKERRLKEVLRVSGVSNSTIRLCWFAENMILLMVPCALISVMVKYGKVLRYSDPS 644

  Fly   142 FMPFTHWSMALFV-LLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFLILHSKGCSEG 205
                     .:|| |||....|:...|.:|...|.....:....|.....|||.::.::.....|
Zfish   645 ---------VIFVFLLVFCLATVMQCFFISVFFSRANLAAACGGLLYFLLYLPHVLCYAWRDVLG 700

  Fly   206 LNVFLSLFLLS------GLQVLVVGICMWEDYGEGLQWGNLFETSWPGGTLSVGYILLVMILASF 264
            ....::..|||      |.:    ....:|..|.|:||.|:..:.......|....:.:|:..:.
Zfish   701 FGAKIATSLLSCVAFGYGCE----NFSTYEAQGVGIQWSNIRSSPQDNDRYSFIVSIFMMLFDAL 761

  Fly   265 LSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTESLLPYSRLFNRIFGIYSAAPDEERPDL---- 325
            :...|..|:|.:.||.||:.:||:||                |...:...|....:..|||
Zfish   762 IYWTLTWYIENVYPGQYGIAKPWYFP----------------FTSSYWCGSRVGSDGHPDLLQDL 810

  Fly   326 ----QLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISML 384
                ..:|..|.....||.||.|.|.:  |....|..:|.|.::..||..:|||||||||.:|:|
Zfish   811 ENQSGFLEKPPSGLKPGVCIRNLVKVYKTGNKLAVDGLSLDFYQDHITSFLGHNGAGKTTTMSIL 875

  Fly   385 AGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSE 449
            .|..:||||||.|||:|||.:....::.:|:|||.||||..|:...||..::||:|....|||.|
Zfish   876 TGLFAPTSGTAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLKGRSSKEVKKE 940

  Fly   450 VQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILE 514
            :...:|.:.|..|::..|:|||||.||:||||.:..||..|:|.|||:.|:||.|||.:|.|:|:
Zfish   941 IDQMIKDVGLPHKRKDLAKNLSGGMQRKLSVAIAFVGGSNVVILDEPTAGVDPYARRGIWELLLK 1005

  Fly   515 AKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGSLPFLKKQVDASCLITC------EARKRC 573
            .|:|.||:|:||.:|:.::|||||.|||.|:::|.||..||||.......:|.      .|..:|
Zfish  1006 YKQGRTIILSTHHMDEADILGDRVAIISHGRVQCCGSSLFLKKTYGRGYYLTIARANQERAPAQC 1070

  Fly   574 ---------------------------DLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLS--KSK 609
                                       |:..::.|:.|||...:.....|:::.|.||.|  .:.
Zfish  1071 VPSPEEFDQSSLDEGICSDSISSLDPPDVSDVSRLVRRHVPEAEFLEAVGQELVYVLPYSGATNG 1135

  Fly   610 YFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDL----------------NSRQSG--- 655
            .|::||::|:.:.|.|||..:.:|..||||||:.. |||.                :||.||
Zfish  1136 SFATLFKELDLEKNTLGVTSYGISDTSLEEIFLKV-AEDTGVDVESHDKPKQKPRSSSRISGKQS 1199

  Fly   656 ---GAEKRDDDDRDDDEE----NEVQDGNVRSC---------------KKQWRAMMTKK------ 692
               ..|.||.....::.:    :.|:|.:...|               ::|:.|:..|:
Zfish  1200 ISSALECRDAKTVKNEAKVRFASRVEDTHRPMCANGKGSDVINGWSLIRQQFLALFIKRFHHARR 1264

  Fly   693 ----VMALYDNKVYFLLLL-----------------LTPIVY-------------------YIT- 716
                ::|......:|:.|.                 |.|.:|                   .:|
Zfish  1265 SRKGIIAQVVMPAFFVCLALIFSLIVPPFNEYPSLELQPWMYGAPQNTFYSFDGPGVVQVEKVTN 1329

  Fly   717 ---------TLMMATKP------HHSGRPTF-------NISD-YGVDKFTILLSVPVSKSYTEER 758
                     |..|:|.|      ..:|...:       :||| :....:|:....|..:..|.||
Zfish  1330 ALLNSPGFGTRCMSTNPIPRLPCVSTGSTNWFTPAVDPSISDIFDKGNWTMQNPSPACQCSTAER 1394

  Fly   759 ------------------RADSIASLIKGKLKLIVVSEQIKDYV----DDKWKSREGRREINFVS 801
                              |..:....::.     |....:.|::    ....|.|.|...:..|:
Zfish  1395 SFMLPDCPPGAGGLPPPQRTQNTTDTLQN-----VTGRNMTDFLLKTYQKSGKIRYGGFSVGGVN 1454

  Fly   802 --MAIDTGDRTGLI------------------------------------------GWVGPRHYV 822
              :.::..|.|.|:                                          ||
Zfish  1455 SQVRLNESDITTLVSDLRSVFNVSQFKQSEDIFQAIRLFLLELGTRDNMKVWFYNPGW------- 1512

  Fly   823 HAAPMILNLVYN-ALAQELIGPK----ISIEVTSVPFTLRKKE---DFLISNNGDI-----PIYV 874
            |:....||:..| ||...|...:    ..|...:.|..|.:::   ..|.|::.|:     .|:.
Zfish  1513 HSLVSFLNVASNGALRGNLPAGRRPEDYGITTFNHPLNLTREQLSTAALASSSTDVVVAICVIFA 1577

  Fly   875 IGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDM----------VVFFIL--- 926
            :.::..:.::|   :|||||:..|.||.|||:....|||::.|:||          ::.|:.
Zfish  1578 MSFIPASFVLF---LIQERVTKAKHLQFVSGVNPTIYWLANFAWDMCNYIVPCVIVIIIFLCFQQ 1639

  Fly   927 ----------VLALLLPLYGYA-----------------PWYLLLCVLFFTGLAG---------- 954
                      .|.|||.|||::                 .:.:|.|:..|.|:.|
Zfish  1640 KSYVSPPNLPALILLLALYGWSITPMMYPFSFVFSVPSTAYVVLTCINLFIGINGSVATFVMELF 1704

  Fly   955 ----------------LIFIYFLI----------------------------------------- 962
                            |:|.:|.:
Zfish  1705 DDPNITRINDIVKQALLVFPHFCLGRGLMDMAKNQAVATLYQNLGEDRFVNPLTWNMVGKNLFAM 1769

  Fly   963 SMLSATFLAVSMI-----------------------------------------LLSVIIGSLIL 986
            |:..|...||:::                                         ||.:...:.:|
Zfish  1770 SIQGAVMFAVTLLIQYKFFCKPRSVKSPFTSSAEEDEDVARERERVYNGGAQKDLLHICDLTKVL 1834

  Fly   987 MILGALALI---------FKMVYVAIYVAN----MHPLIAG---------YNC-----------I 1018
            :....||::         |....::.::.|    ..|  ||         :|.           :
Zfish  1835 LKNPVLAVVLDQTLENTGFSSAVISNFLFNGPESERP--AGMPSFDWRNVFNATSQSAQQLTQIL 1897

  Fly  1019 QKCFHYMSLCGSYISEAQNPLS-ENLTSDEMYCINPLAFLEPRC----------------VCVNP 1066
            :.|.|.:    ..::::.:|.: :|..:|..|......:|:...                |....
Zfish  1898 KVCLHLL----KGVTKSWSPTARDNPLNDLRYVRGGFVYLQDMVDRAIIKLQTGVQQTLGVYAQQ 1958

  Fly  1067 MTWP-------------------------------------------DMLVMLG----------- 1077
            |.:|                                           :.:.|:|
Zfish  1959 MPYPCYMDDAFLRSLTRSLPLYMTLAWIFSVALIVKGVVQEKEARLKETVRMMGLKSSTYWLSWA 2023

  Fly  1078 -----------------------------TAIILFLLI-------------MFFE---------- 1090
                                         :.|.:|||:             :||.
Zfish  2024 ISSTLPLAVSAALLTLILKYGKVLRYSDPSVIFVFLLVFCLATVMQCFFISVFFSRANLAAACGG 2088

  Fly  1091 ---------------------YG--------SCV--WYRCKGCCPYSSKGSIEDPKVSREAEKIR 1124
                                 :|        |||  .|.|:....|.::|      |..:...||
Zfish  2089 LLYFLLYLPHVLCYAWRDVLGFGAKIATSLLSCVAFGYGCENFSTYEAQG------VGIQWSNIR 2147

  Fly  1125 AMDADQIGTRALVVN--------------------------GVSK--------KYGC-------- 1147
            :...|. ...:.:|:                          |::|        .|.|
Zfish  2148 SSPQDN-DRYSFIVSIFMMLFDALIYWTLTWYIENVYPGQYGIAKPWYFPFTSSYWCGSRVGSDG 2211

  Fly  1148 --------------------------------------DQLAVNNISFALKPSHCVGLLGPNGAG 1174
                                                  ::|||:.:|......|....||.||||
Zfish  2212 HPDLLQDLENQSGFLEKPPSGLKPGVCIRNLVKVYKTGNKLAVDGLSLDFYQDHITSFLGHNGAG 2276

  Fly  1175 KTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGF 1239
            ||||..::.|..:...|..||:||.:|...:...|:||.|||.:..|:.||..:.:..:..:.|.
Zfish  2277 KTTTMSILTGLFAPTSGTAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLKGR 2341

  Fly  1240 PSKDLNKRCEKLADQFGF---RKHLDKKIT 1266
            .||::.|..:::....|.   ||.|.|.::
Zfish  2342 SSKEVKKEIDQMIKDVGLPHKRKDLAKNLS 2371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	137/343 (40%)
		ABC_subfamily_A	339..556	CDD:213230	105/218 (48%)
		ABC2_membrane_3	<821..1018	CDD:289468	63/390 (16%)
		CcmA	1135..1450	CDD:224054	45/215 (21%)
		ABC_subfamily_A	1136..1354	CDD:213230	45/214 (21%)
LOC101883122	XP_021333309.1	AAA	1..1833	CDD:333001	314/1362 (23%)
LOC101883122	XP_021333309.1	AAA	1835..>2372	CDD:333001	83/550 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010