Protein Alignment CG42816 and abca5

DIOPT Version :10

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: NP_001135599.1
• Gene: abca5 / 100216156
• XenbaseID: XB-GENE-1012902
• Length: 1639
• Species: Xenopus tropicalis
• Alignment Length: 1555
• Identity: 403/1555 - (25%)
• Similarity: 697/1555 - (44%)
• Gaps: 327/1555 - (21%)

  Fly    68 IMIIVIIIFF--VVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLF 130
            :|.:.:::.|  :..|:...:|.|||.::|..:.|||:.....|:.|      :.|....|:.:
 Frog   222 LMSVFLVMAFSPLGYSVAFYVVFEKEKKVKEFMKLMGLHDTAFWLPW------VLLYTGFILVI- 279

  Fly   131 WKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFL 195
             .||:.....:|.||:.           |:|.:.|      |:...|.||||.|..::|.    |
 Frog   280 -SLVMAVVATTFFPFSK-----------SNCFLIF------LLYALYGISLVLFALMLAP----L 322

  Fly   196 ILHSKGCSEGLNVFLSLFLLSGLQVLVV-----------------------GICM---WEDYGEG 234
            ..:||  ..|..||||...|..:.:.:|                       ||..   .||:..|
 Frog   323 FKNSK--RAGAIVFLSTLALGAVGIFIVLKEDFPKSFVWFFSPFCQCTFMIGIAQVLHLEDFQRG 385

  Fly   235 LQWGNLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQ-PWHFPCTRCCSTE 298
            .|:.:|.:..:|   |.:.:|.||  :.|.:.|||..||:::.||.||:.| |:.|
 Frog   386 AQFTHLKDGPYP---LVITFIFLV--VDSVMYLLLATYLDQVLPGEYGLRQSPFFF--------- 436

  Fly   299 SLLP--YSRLFNRIFGIYSAAPDEERPDL-QLIEPDPVD---KIAGVQIRGLSKTFGKMEVVKN- 356
             |.|  :|:...| :|..:.:..:...|: ::|||...:   |.| ::|..:.|:|.|....:|
 Frog   437 -LKPSYWSKRKKR-YGELNESYFDRAVDMSEVIEPVSAELHGKEA-IRICCICKSFRKNNKPRNA 498

  Fly   357 ---VSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIR--QERRQAQRCIGLC 416
               ::||::|||||.|:||:|.|||||:::|.|...||.|.|.:.|..:.  .|.::|.:..|:|
 Frog   499 LQGLTFDIYEGQITALVGHSGTGKTTLMNILCGLCPPTEGFATVYGHRVTDIDEIQEASKMTGIC 563

  Fly   417 PQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVA 481
            .|.::.|..|:...::.:|:.|||:.....:.|:...|..|::|..|...||.||.|.:|:||||
 Frog   564 QQTDIFFDVLTVEENLHIFASLRGIDEKTKEQEINKILFDLDMQALKHNHARTLSIGQKRKLSVA 628

  Fly   482 CSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQL 546
            .::.|..|||:.|||:.|:|..:|..:|.|:.:.|.....:.:||.:::.::|.||..:||.|.|
 Frog   629 IAVLGNPKVLLLDEPTAGMDSCSRHTVWDLLKKRKGKHVTVFSTHCMEEADILADRKAVISQGSL 693

  Fly   547 RCIGSLPFLKKQVDASCLITCEARKRCDLEKLTSLISRHVGTIQPFSIKGRDVCYKLPLSKSKYF 611
            :||||..|||.:......::.:.:|.||::.|:|||::|:............:.|.|||.....|
 Frog   694 KCIGSSLFLKSKWGVGYRLSMDIKKPCDVDALSSLITQHISGASLMQQSENSLLYSLPLKDVSKF 758

  Fly   612 SSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLNSRQSGGAEKRDDDDRD-----DDEEN 671
            ..||..|:|..: ||:..:.:|:.:||::|.....|....:..|...:|:.:|..     :|.|.
 Frog   759 PGLFSALDSGSD-LGIITYGVSATTLEDVFFKLETEAEIDQTDGIFNQRNLEDEGKWKSMEDIEQ 822

  Fly   672 EVQDGNVRS--CKKQWRAMMTKKVMALYDNKVYF-------------LLLLLTPIVYYITTLMMA 721
            .:.:.::.|  |.....|:..::|.|:  .|::|             .|.||..:|..:|...:.
 Frog   823 GLLELSLESSPCSVTGSALWKQQVAAV--AKLHFRNLHRESKSFRCVCLCLLFFLVPQLTLYFLG 885

  Fly   722 TKPHHSGRPTFNISDYGVDKFTILLSVPVSKSYTEERRADSIASL------------IKGKLKLI 774
            ...|.|..|             |.||..:..|:.:::....:.||            :.|.|.
 Frog   886 LSYHQSLAP-------------IRLSADMYFSHPKQKSHKFLTSLLLQNSTGTNLDELLGNLN-- 935

  Fly   775 VVSEQIKDYVDDKWKSREGRREINFVSMAIDTGDRTGLIGWVGPRHY----------VHAAPMIL 829
              |::||  ||          .||.......:.....|..::..:||          ||:.|:::
 Frog   936 --SQKIK--VD----------LINGSDYMSASPHNAALNVFLSGKHYTYEAIFNSSMVHSLPVLI 986

  Fly   830 NLVYNALAQELIGPKISIEVTSVPFTLRKKEDFLISNNGDIPIYVIGYVSIAMIIFSSAVIQERV 894
            |.:.|:|.::| |...||||.:.||    .:|||.::.|....::|.|:.|...:.....::...
 Frog   987 NTISNSLLRQL-GVNESIEVWNSPF----YQDFLHTSYGLDFYFLIAYLGIMTGMLPYIAMENAY 1046

  Fly   895 SH-------MKMLQEVSGLEMITYWLSHLAFDMVVFFIL---------------------VLALL 931
            :|       :||    :||....||:.....|:.:||::                     |||::
 Frog  1047 NHKVKAYSQLKM----AGLYPSAYWVGQAVVDIPLFFLMLLFMVGSMLAFKSGIDLHAGTVLAMI 1107

  Fly   932 LPLYGYAPWYLLLCVLFFTGLAGLIFIYFLI-------SMLSATFLAVSMILLSVII---GSLIL 986
            ..|.||.|..:||..:       :.|.|.||       |::.|...::|:|::...|   .|:.:
 Frog  1108 FCLIGYVPAVVLLTYV-------VSFTYKLINDTRQWWSLIFAVTASISIIIIEAAIFFASSVTV 1165

  Fly   987 MILGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCI 1051
            ..|.....||..||         ||:....|..|                  :|.||...::..:
 Frog  1166 TRLHVFFSIFFPVY---------PLLGCLTCFIK------------------MSRNLAHSDVKGL 1203

  Fly  1052 NPLAFLEPRCVCVNPMTWPDMLVMLGTA----IILFLLIMFFEYGSCVWYRCKGCCPYSSKGSIE 1112
            ..|..|               ||.:...    :|.||::.:.|            ..|..:...:
 Frog  1204 TQLGRL---------------LVAVFAPYVHFLIFFLILRYLE------------MKYGGRSIRK 1241

  Fly  1113 DPKVSREAEKIRAM---------DADQIGTRA---------------LVVNGVSKKYGCDQ---- 1149
            ||....:.:|.:..         |.|....||               ::|:|:.|:.  ||
 Frog  1242 DPVFRSQTKKTKPWKFAEVPEDEDEDVKVERARVGEYMAPDCNEKPMVLVSGLHKEQ--DQTGKT 1304

  Fly  1150 --------LAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNK 1206
                    |.|||:||.::....|||:|||||||:|...|:||:..::.|.|.:...:.......
 Frog  1305 ILGKAMRKLVVNNVSFCVRKGETVGLVGPNGAGKSTLLNMMVGQSELNAGQILMGDPAAGEPGLS 1369

  Fly  1207 AMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGG 1271
            ..:.|||.||::.|:..:..::.|:.:..|.|..|..|.:...::.:....:.||.:.....|.|
 Frog  1370 PPRFLGYSPQTNYFWPEIKLQEHLETYGAIKGMGSNVLKEVTRRIVETLDLKDHLQEPAKKLSVG 1434

  Fly  1272 TKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGK--AVLLTSHNMDEINALC 1333
            .:||::.|:: .|...::.|:|||.|:||.:::.:|.:| ....:||  |.::|:|:|:|..|:|
 Frog  1435 NQRKLSFALSMLGNPDIVLLEEPSTGMDPKNKQIMWKVI-RTTLKGKEQAAVITTHSMEEAEAIC 1498

  Fly  1334 SKSVILVDGSIYAMGSVQHVKNKIAK--GMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKE 1396
            .:..|:|.|.:..:|||||:|:|..:  .:.|||....:..| |..|.|   :|...:|||..:|
 Frog  1499 DRVAIMVSGQLRYIGSVQHLKSKFGRYFSLELKLDTRARSQN-VEFLHK---EILQIFPNASHQE 1559

  Fly  1397 KYEFSGRLTFQISKD--TSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKK 1454
              .||..:::::.|:  .|.|:.|..:|..:..:::|:|..||.:||..|.|:|:|:.::
 Frog  1560 --SFSSLMSYKVPKEDVESLSQTFSKLEQVKQMYNIEEYIFSQATLEQVFIELAKEQEEE 1617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	400/1535 (26%)
abca5	NP_001135599.1	rim_protein	<87..1616	CDD:130324	403/1552 (26%)