Protein Alignment CG42816 and abca2

DIOPT Version :9

• Sequence 1: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Sequence 2: XP_005165286.1
• Gene: abca2 / 100006090
• ZFINID: ZDB-GENE-050517-1
• Length: 2504
• Species: Danio rerio
• Alignment Length: 1824
• Identity: 441/1824 - (24%)
• Similarity: 771/1824 - (42%)
• Gaps: 471/1824 - (25%)

  Fly     8 YPLYKTGFLAVQQALSQVHIKHKCKEFNKTQG-DIKFPP--IKDLPSPPIFKSDNSSTLQDVGIM 69
            |.||  ||:.:|..:.:..|       |...| |:..|.  ::..|.|...:.|....::.:..:
Zfish   708 YFLY--GFVWIQDMIERAII-------NTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPL 763

  Fly    70 IIVIIIFFVVVSLTKSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQTFIIFLIGSSIITLFWKL- 133
            .:||...:.|..:.:.||.|||.:||..:.:||:.:.:.||||:|..|:...|..:.:|...|.
Zfish   764 CMVISWVYSVAMMIQHIVAEKEQRLKEVMKMMGLNNAVHWVAWFITGFVQLSISVTALTAILKYG 828

  Fly   134 -VLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISLVTFLALIATYLPFL-- 195
             ||.:|:    ||..|   || |.:.:..||.|.||:|.|.|.....|....:....:|:|::
Zfish   829 KVLLHSD----PFIIW---LF-LTIYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYV 885

  Fly   196 -----ILHSKGCSEGLNVFLSLF---LLSGLQVLVVGI-----CMWEDYGEGLQWGNLFETSWPG 247
                 :.|.|         ::.|   :.|.:.....|:     .::|..|.|:||..:.::...|
Zfish   886 AIREEVAHDK---------ITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWRTINQSPVEG 941

  Fly   248 GTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTR------------------- 293
            ...::...::::.:.:.:..:|..|:|.:.||.||:|:||:||..:
Zfish   942 DDFNLLLSMVMLTIDAIVYGVLTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRIETWEWPWGGG 1006

  Fly   294 ----------CCSTESLLPYSRLFNRIFGIYSAAPDEERPD-LQLIEPDPVDKIAGVQIRGLSKT 347
                      .|:.|     .|......||      ||.|: |.|:.  .:||:..|.     ||
Zfish  1007 TRLSVMEEDQACAME-----HRRSEETRGI------EEEPNHLPLVV--CIDKLTKVY-----KT 1053

  Fly   348 FGKMEVVKNVSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRC 412
            ..|:.:.| :|.::.|.|:...:|||||||||.:|:|.|...||||:|.|.|.|||.|..:.::.
Zfish  1054 GSKLALNK-LSLNLHENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMERIRQN 1117

  Fly   413 IGLCPQQNVLFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRR 477
            :|:|||.||||..||...|:..:|||:|:...:::.|:...::.|.|..|:....:.||||.:|:
Zfish  1118 LGMCPQHNVLFDKLSVEEHLWFYSRLKGMAEEDIRKEMDKMIEDLELSNKRHSLVQTLSGGMKRK 1182

  Fly   478 LSVACSLCGGVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIIS 542
            ||||.:..||.:.:|.|||:.|:||.|||.:|.|||:.|:|.||||:||.:|:.::||||:.|||
Zfish  1183 LSVAIAFVGGSRAVILDEPTAGVDPYARRAIWDLILKYKQGRTILLSTHHMDEADLLGDRIAIIS 1247

  Fly   543 DGQLRCIGS-------------LPFLKKQ-----VDASCLITCEARKRCDLEKLTSLISRHVGTI 589
            .|:|:|.||             |..:|||     .|.|......:...|...::|..|.::|.:.
Zfish  1248 HGKLKCCGSPLFLKSTYGDGYKLTLVKKQSDSHTADQSSQSPSSSISPCSENRVTQFIRQYVASC 1312

  Fly   590 QPFSIKGRDVCYKLPLS--KSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSFGAEDLN-- 650
            ...|....::.|.||..  |...|..||:.||..::.|.:..|.:...:|||:|:....|||:
Zfish  1313 LLVSDSNTELSYVLPSEAVKKGCFERLFQALEQSLDSLALTSFGVMDTTLEEVFLKVSEEDLSLE 1377

  Fly   651 --------------------------------------------------------SRQSG---G 656
                                                                    |.|||   |
Zfish  1378 NSDADMKDSPGGASAGKPSGLLGGPQCEGAPAAAVMRPEVELSNLMMCSRLSPSQASLQSGSSLG 1442

  Fly   657 AEKRDD---------------DDRDD-------DEENEVQ------------DG----------- 676
            :.:.|:               |:..|       |||:..|            ||
Zfish  1443 SVRGDEGGPYSEFYGDYCPLFDNGQDLDSASLRDEESSPQPTVLEGQGSFKLDGWWLKLRQFHGL 1507

  Fly   677 ---NVRSCKKQWRAMMTKKVMALYDNKVYFLLLLLTPIVYYITTLMMATKPHHS-GRPTFNISDY 737
               .....|:..:.:.::.::..:...|...:.|..|.:..:..|:::...:|: .:|..|...|
Zfish  1508 IVKRFHCAKRNTKGIFSQILLPAFFVCVAMTVALSVPEIGDLPPLILSPSQYHNYTQPRGNFIPY 1572

  Fly   738 GVD-------KF---------------------TILLSVPVSKS--------------------- 753
            ..:       ||                     |.:|..|.:.:
Zfish  1573 ANEDRSQYRTKFSPDAGPQRIVNTLRLPSGVGATCILKTPFNSTLDQLAQTLNPYANNSKTLAAR 1637

  Fly   754 YTEERRADS-------------------------------------------------------- 762
            |.:....||
Zfish  1638 YFDSMCLDSFTQGVPLSNFVPPPPSPAPSDDPEAHFEDGLWNYTAAPTTVREMATSPPTLPLSIH 1702

  Fly   763 -------------------------IASLIKGKLKLIVVSEQIKDYV---DDKWK-SREGRREIN 798
                                     :..::.|.:.:.:....:.:|:   .|:.: .|.|...:.
Zfish  1703 EPVRCICSMQGTGFSCPSGVGGRPPLMKVVTGDILVDITGRNVSEYLLYTSDRLRLHRYGGFTVG 1767

  Fly   799 FVSMAIDT--GDRT-GLIGWVGPRHY---------VHAAPMILNLVYNALAQELI-----GPK-I 845
            .:..::..  |.:| .::..:..|..         .|:.|..||::.||:.:..:     .|. .
Zfish  1768 NIQKSVPASFGRKTPPMVRKIAVRRSSQVLYNNKGYHSMPTYLNVLNNAILRANLPSSKGNPSAY 1832

  Fly   846 SIEVTSVPFTLRKKE---DFLISNNG-DIPIYVI---GYVSIAMIIFSSAVIQERVSHMKMLQEV 903
            .|.||:.|.......   |:|:.... .|.|::|   .:|..:.::|   ::.|:.:..|.||.|
Zfish  1833 GITVTNHPMNRTSASLSLDYLLQGTDVVIAIFIIVAMSFVPASFVVF---LVAEKSTKAKHLQFV 1894

  Fly   904 SGLEMITYWLSHLAFDMVVFF------ILVLALL-LPLYGYA---PWYLLLCVLFFTGLAGLIF- 957
            ||.:.:||||::..:||:.:.      :|:|.:. ||.|...   |..|.|.:|:...:..:::
Zfish  1895 SGCDPVTYWLANYIWDMLNYLVPATCCVLILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYP 1959

  Fly   958 --IYFLISMLSATFLAVSMILLSVIIGSLILMILGALALIFK----MVYVAIYVANMHPLIAGYN 1016
              .:|.:...:..||    |::::.|| :...:...|..:|:    :..|..|:.:...:...||
Zfish  1960 ASFWFEVPSTAYVFL----IVINLFIG-ITATVATFLLQLFERDKDLKLVNSYLKSCFLIFPNYN 2019

  Fly  1017 ----CIQKCFHYMSLCGSYISEAQNPLSENLTSDEMYCINPLAFLEPRCVCVNPMTWP----DML 1073
                .::..::      .||:|....:.:   .|::               .:|..|.    .::
Zfish  2020 LGHGLMEMAYN------EYINEYYAKIGQ---FDKV---------------KSPFEWDIVTRGLV 2060

  Fly  1074 VMLGTAIILFLLIMFFEYGSCVWYRCKGCCPYSSKGSIEDPKVSREAEKIRAM--DADQIGTRAL 1136
            .|.....:.||:.:..:|.   :.|.....|.:|: .:||..|....|:.|.:  |||   ...|
Zfish  2061 AMTIEGFVGFLITILCQYN---FLRKAQRVPVNSQ-PVEDDDVDVACERRRVLRGDAD---NDML 2118

  Fly  1137 VVNGVSKKYGCDQ----LAVNNISFALKPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISG 1197
            .::.::|.|...:    |||:.:...::|..|.||||.|||||||||||:.|:.|...|..:|..
Zfish  2119 KIDNLTKVYKSRKMGRILAVDRLCLGVRPGECFGLLGVNGAGKTTTFKMLTGDESTTGGEAFIQE 2183

  Fly  1198 YSMRMKRNKAMKELGYCPQSDSFFEFLTGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLD 1262
            :|:..:..:..:.:|||||.|:.|:.||.|:.|:::..:.|.|.||..:..:...::....|:.|
Zfish  2184 HSILRELLRVQQSIGYCPQFDALFDDLTAREHLELYTRLRGIPWKDEERVVQWALEKLELSKYAD 2248

  Fly  1263 KKITYYSGGTKRKINAAVA-CGANSLICLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNM 1326
            |....||||.|||::.|:| .|..|||.||||:.|:||.:||.:|.:|.::.:.|::|:||||:|
Zfish  2249 KPAGTYSGGNKRKLSTAIALIGYPSLIFLDEPTTGMDPKARRFLWNLILDIIKTGRSVVLTSHSM 2313

  Fly  1327 DEINALCSKSVILVDGSIYAMGSVQHVKNKIAKG--MTLKLVVNVQPDNMVAMLTKIEDDIYMTY 1389
            :|..|||::..|:|:|....:||:||:||:...|  :|::.........::....:       .:
Zfish  2314 EECEALCTRLGIMVNGRFKCLGSIQHLKNRFGDGYMITVRTKTTASVKEVIRFFNR-------NF 2371

  Fly  1390 PNAELKEKYEFSGRLTFQI-SKDTSWSEIFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRK 1453
            |.|.|||::.  .::.:|: |::.|.:::|..:|.......:||||:||.:|::.|...|    |
Zfish  2372 PEAILKERHH--TKIQYQLKSENISLAQVFSKMEQVVEVLSIEDYSVSQTTLDNVFVNFA----K 2430

  Fly  1454 KKSN 1457
            |:|:
Zfish  2431 KQSD 2434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42816	NP_730301.3	CcmA	336..643	CDD:224054	122/326 (37%)
		ABC_subfamily_A	339..556	CDD:213230	97/229 (42%)
		ABC2_membrane_3	<821..1018	CDD:289468	52/239 (22%)
		CcmA	1135..1450	CDD:224054	111/322 (34%)
		ABC_subfamily_A	1136..1354	CDD:213230	88/222 (40%)
abca2	XP_005165286.1	rim_protein	1..2435	CDD:130324	441/1824 (24%)
		ABC_subfamily_A	1042..1261	CDD:213230	98/226 (43%)
		ABC_subfamily_A	2118..2341	CDD:213230	88/222 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010