DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-A and ADA2

DIOPT Version :9

Sequence 1:	NP_524130.1	Gene:	Adgf-A / 39976	FlyBaseID:	FBgn0036752	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001269154.1	Gene:	ADA2 / 51816	HGNCID:	1839	Length:	511	Species:	Homo sapiens

Alignment Length:	471	Identity:	193/471 - (40%)
Similarity:	281/471 - (59%)	Gaps:	12/471 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 EESRSLGHDLDLNSREIKANETIMKAKLKEFDEGLVTPHLFKPSQHIFDVLDGIRNTDLFKLLKK 141
            |:...||..|.||::|..|||.:|..|:.|..|.:.| .:|.||.|.|.....|..:.:|.:|:.
Human    41 EKMMRLGGRLVLNTKEELANERLMTLKIAEMKEAMRT-LIFPPSMHFFQAKHLIERSQVFNILRM 104

  Fly   142 MPKGAVLHAHDTALCSTAAII-NLTYYEHLWSCQQDGDLSASALRFSKDKPQALSDCD-WSLLSD 204
            |||||.||.||..:.:...:: |:||..|...|.....:  ...||:...|:....|. |.||.|
Human   105 MPKGAALHLHDIGIVTMDWLVRNVTYRPHCHICFTPRGI--MQFRFAHPTPRPSEKCSKWILLED 167

  Fly   205 VRAK-YGADKVDDYLAERLTL---YPTKKFEDNNAAWSTFMSIFNLLDGLVMYAPVWADYYYKAL 265
            .|.: ....:.||.|....||   :|...:.:.|..||.|.:||..:.||:.||||:.||.::::
Human   168 YRKRVQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSM 232

  Fly   266 EEFYEDGVLYLEFRSVVPTLYDMDGTEFTPMDTVRIYVETLEKFKEAHPDFIGSRMIYAPIRYTN 330
            :|||||.|||:|.|:.:..:|::.|.......:|:.|.|..:||.|.||:|||.::||:..|..:
Human   233 QEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKD 297

  Fly   331 AEGVTGYIQTLKQIKEKYPEFVAGFDLVGQEEMGRPLRDFVDELLSIPDD---IDFYFHAGETNW 392
            ...:...|:....::.|:|..||||||||.|:.|..|.|:.:.|:....|   :.::||||||:|
Human   298 VAVIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLPYFFHAGETDW 362

  Fly   393 FGSTVDENLIDAILLGTKRIGHGFGLVKHPVVLDMLKKLNVAIEVNPISNQVLQLVSDFRNHPCS 457
            .|:::|.|::||::|.|.||||||.|.|||.|.....|.::.|||.|||||||:||||.||||.:
Human   363 QGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVA 427

  Fly   458 HFFADGYPVVISSDDPSFWKATPLTHDFYIAFLGIASQHSDLRLLKKLALNSIQYSSLTGDAQFE 522
            ...|.|:|:|||||||:.:.|..|::|||..|:||....:|||.||:||:|||:||:|....:..
Human   428 TLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNT 492

  Fly   523 ALEKWQVKWDQFIADV 538
            .:|.|:.:||:|||||
Human   493 FMEIWKKRWDKFIADV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A	NP_524130.1	A_deaminase_N	54..139	CDD:285627	22/61 (36%)
		adm_rel	66..538	CDD:273620	191/469 (41%)
		ADGF	119..531	CDD:238646	170/420 (40%)
ADA2	NP_001269154.1	A_deaminase_N	12..102	CDD:285627	22/61 (36%)
		adm_rel	30..509	CDD:273620	193/471 (41%)
		Dimerization	30..100		21/59 (36%)
		ADGF	82..501	CDD:238646	170/420 (40%)
		PRB domain	127..185		17/59 (29%)
		Substrate binding	204..211		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159070
Domainoid	1	1.000	263	1.000	Domainoid score	I1937
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2230
Isobase	1	0.950	-	0	Normalized mean entropy	S2696
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		otm41530
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720