DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-A and ada2a

DIOPT Version :9

Sequence 1:	NP_524130.1	Gene:	Adgf-A / 39976	FlyBaseID:	FBgn0036752	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001028889.2	Gene:	ada2a / 373884	ZFINID:	ZDB-GENE-030902-4	Length:	503	Species:	Danio rerio

Alignment Length:	487	Identity:	201/487 - (41%)
Similarity:	292/487 - (59%)	Gaps:	22/487 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GRPTPDTYKTLRSAFFRYEESRSLGHDLDLNSREIKANETIMKAKLKEFDEGLVTPHLFKPSQHI 123
            |||.|    ..|.|....|.||..|.|:.||.||...:..:.|.|..:.:.|     .|.||.|.
Zfish    24 GRPDP----RKRDALIGLEASRRTGGDITLNEREKLLDGKLQKLKQHDMEAG-----QFPPSMHF 79

  Fly   124 FDVLDGIRNTDLFKLLKKMPKGAVLHAHDTALCSTAAII-NLTYYEHLWSCQQDGDLSASALRFS 187
            |.....|..:.:|.|::||||||.||.||.|:.|...:: |:||.|:.:.|..  |.......||
Zfish    80 FKAKRLIDQSPVFNLIQKMPKGAALHVHDFAMVSVDWLVKNVTYRENCYVCFT--DKQTVQFIFS 142

  Fly   188 KDKPQALSDC-DWSLLSDVRAKY-GADKVDDYLAERLTLY---PTKKFEDNNAAWSTFMSIFNLL 247
            ...|.:.|.| .|:||..:|.|. ...::|:.....|||:   |.:.:.:.:..|..|..:|.:.
Zfish   143 SGPPASSSHCSSWTLLRSLREKIKNTTELDNSFIRNLTLFTEDPDRAYPNQDTVWERFEQVFLVA 207

  Fly   248 DGLVMYAPVWADYYYKALEEFYEDGVLYLEFRSVVPTLYDMDGTEFTPMDTVRIYVETLEKFKEA 312
            .|||.||||:.||.|:.|.:||||.::|:|.|:::|..|::||.......::....|.:.:||:.
Zfish   208 YGLVTYAPVFKDYLYEGLRQFYEDNIMYVEIRALLPQTYELDGRLNDKDWSMAACQEVVNQFKKH 272

  Fly   313 HPDFIGSRMIYAPIRYTNAEGVTGYIQTLKQIKEKYPEFVAGFDLVGQEEMGRPLRDFVDELLSI 377
            ||||||:|:|:...|..||......::....::..:|:.:||||.||||::||||..|.| .||:
Zfish   273 HPDFIGARVIFTVHRKINATEAVKTVEEAMILRRNFPDVMAGFDFVGQEDLGRPLWYFKD-ALSL 336

  Fly   378 PDD----IDFYFHAGETNWFGSTVDENLIDAILLGTKRIGHGFGLVKHPVVLDMLKKLNVAIEVN 438
            |:|    :.::||||||:..|:.||:||:||:|..|.||||||.|.:||||.:|.:|:.|.|||.
Zfish   337 PEDKGFNLPYFFHAGETDSQGTDVDQNLMDALLFNTTRIGHGFALARHPVVKEMARKMYVPIEVC 401

  Fly   439 PISNQVLQLVSDFRNHPCSHFFADGYPVVISSDDPSFWKATPLTHDFYIAFLGIASQHSDLRLLK 503
            |||||||:||||.|:||.:...|:|:|:|||||||:.:.||.|:||||.||:|......:|..||
Zfish   402 PISNQVLKLVSDLRDHPAAVLMAEGHPLVISSDDPAVFGATALSHDFYEAFMGFGGMSFNLGTLK 466

  Fly   504 KLALNSIQYSSLTGDAQFEALEKWQVKWDQFI 535
            :|||||::||:|:...:.||::...||||:|:
Zfish   467 ELALNSLRYSTLSSQRKEEAIDALLVKWDKFV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A	NP_524130.1	A_deaminase_N	54..139	CDD:285627	25/79 (32%)
		adm_rel	66..538	CDD:273620	197/480 (41%)
		ADGF	119..531	CDD:238646	178/421 (42%)
ada2a	NP_001028889.2	A_deaminase_N	<29..95	CDD:285627	21/70 (30%)
		adm_rel	30..502	CDD:273620	197/477 (41%)
		ADGF	75..494	CDD:238646	178/421 (42%)
		Substrate binding. /evidence=ECO:0000250	197..204		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595071
Domainoid	1	1.000	269	1.000	Domainoid score	I1799
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2141
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		mtm8425
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17359
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800