DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-A and Adgf-E

DIOPT Version :9

Sequence 1:	NP_524130.1	Gene:	Adgf-A / 39976	FlyBaseID:	FBgn0036752	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	243/499 - (48%)
Similarity:	342/499 - (68%)	Gaps:	9/499 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LLTIYGSTPHVEALLGPGRPTPDTYKTLRSAFFRYEESRSLGHDLDLNSREIKANETIMKAKLKE 106
            ||.:.|:|       ...:.||..|:.||..|..:|....:|:|:.|...|..|||.||..|.:|
  Fly    35 LLEMLGTT-------NLRKSTPKDYRILREIFNSFERYSGVGNDIQLTLPERAANELIMCEKKRE 92

  Fly   107 FDEGLVTPHLFKPSQHIFDVLDGIRNTDLFKLLKKMPKGAVLHAHDTALCSTAAIINLTYYEHLW 171
            :::|::.|..|.|..|||.||..::.:.||::|::|||||.|.||||::||:..:|.:||.::||
  Fly    93 YEKGIMDPSKFAPGHHIFQVLTKVKKSPLFQILRRMPKGAALKAHDTSMCSSRVVIEITYRDNLW 157

  Fly   172 SCQQDGDLSASALRFSKDKPQALS--DCDWSLLSDVRAKYGADKVDDYLAERLTLYPTKKFEDNN 234
            .|...........||:||||:.:|  :.:|..:..:|...|.:.:..||..|.::||...|..|.
  Fly   158 VCTTQNGCRVEEFRFAKDKPKDVSFENGEWQPMEKLRELRGEENLRKYLQMRFSMYPLASFTTNA 222

  Fly   235 AAWSTFMSIFNLLDGLVMYAPVWADYYYKALEEFYEDGVLYLEFRSVVPTLYDMDGTEFTPMDTV 299
            .||...|.||.|||||:.|||||.||||.||:|||.|||.|||.|||:|.||.:||:.....:||
  Fly   223 HAWRHMMGIFGLLDGLLQYAPVWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRETV 287

  Fly   300 RIYVETLEKFKEAHPDFIGSRMIYAPIRYTNAEGVTGYIQTLKQIKEKYPEFVAGFDLVGQEEMG 364
            :||.:|||:||:.||.||.|::||||||:...|.|..||:...::.:::|.||.||||||||::|
  Fly   288 QIYKDTLERFKKEHPGFIDSKLIYAPIRHVQPELVGEYIKECTELNKEFPSFVVGFDLVGQEDVG 352

  Fly   365 RPLRDFVDELLSIPDDIDFYFHAGETNWFGSTVDENLIDAILLGTKRIGHGFGLVKHPVVLDMLK 429
            .||.:|..|||.:||.|.||||||:|||:||.||:||:|||:|||||||||:.:.||||::.:.|
  Fly   353 HPLSNFAAELLKLPDHIHFYFHAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPVLMRLAK 417

  Fly   430 KLNVAIEVNPISNQVLQLVSDFRNHPCSHFFADGYPVVISSDDPSFWKATPLTHDFYIAFLGIAS 494
            .||:|:||.|:|||||||.||:|:||.:...|:..|:||:|..|.||:|.||:||||:||||||.
  Fly   418 YLNIALEVCPVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSPGFWRAAPLSHDFYMAFLGIAP 482

  Fly   495 QHSDLRLLKKLALNSIQYSSLTGDAQFEALEKWQVKWDQFIADV 538
            .::||:.||:.|.|||:||||..:|:.||:|||:.:||:::.::
  Fly   483 MNADLKFLKRTAKNSIKYSSLKDEAKAEAMEKWKKQWDKWVENI 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A	NP_524130.1	A_deaminase_N	54..139	CDD:285627	29/84 (35%)
		adm_rel	66..538	CDD:273620	237/473 (50%)
		ADGF	119..531	CDD:238646	216/413 (52%)
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627	29/78 (37%)
		adm_rel	52..527	CDD:273620	237/475 (50%)
		ADGF	105..519	CDD:238646	216/413 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469130
Domainoid	1	1.000	269	1.000	Domainoid score	I1799
eggNOG	1	0.900	-	-		E1_COG1816
Homologene	1	1.000	-	-		H45775
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2141
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		mtm6590
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	P	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
	13	12.810