DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-A and Ada

DIOPT Version :9

Sequence 1:	NP_524130.1	Gene:	Adgf-A / 39976	FlyBaseID:	FBgn0036752	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001258981.1	Gene:	Ada / 11486	MGIID:	87916	Length:	352	Species:	Mus musculus

Alignment Length:	307	Identity:	73/307 - (23%)
Similarity:	127/307 - (41%)	Gaps:	65/307 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 DYY---------------YKALEEFYEDGVLYLEFR---------SVVPTLYDMDGTEFTPMDTV 299
            |||               |:.:|...::||:|:|.|         .|.|..::....:.||.|.|
Mouse    66 DYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGDVTPDDVV 130

  Fly   300 RIYVETLEKFKEAHPDFIGSRMIYAPIRYTNAEGVTGYIQTLKQIKEKYPEFVAGFDLVGQEEM- 363
            .:..:.|::.::|..  |..|.|...:|:..:..    ::.|:..|:...:.|...||.|.|.:
Mouse   131 DLVNQGLQEGEQAFG--IKVRSILCCMRHQPSWS----LEVLELCKKYNQKTVVAMDLAGDETIE 189

  Fly   364 GRPLRDFVDELLSIPDDIDFY-----------FHAGETNWFGS-TVDENLIDAILLGTKRIGHGF 416
            |..|         .|..::.|           .||||.   || .|....:|  :|.|:|:|||:
Mouse   190 GSSL---------FPGHVEAYEGAVKNGIHRTVHAGEV---GSPEVVREAVD--ILKTERVGHGY 240

  Fly   417 GLVKHPVVLDMLKKLNVAIEVNPISNQVLQLVSDFRNHPCSHFFADGYPVVISSDDPSFWKATPL 481
            ..::...:.:.|.|.|:..||.|.|:.:.........|....|..|.....:::|||..:|:| |
Mouse   241 HTIEDEALYNRLLKENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKST-L 304

  Fly   482 THDFYIA--FLGIASQHSDLRLLKKLALNSIQYSSLTGDAQFEALEK 526
            ..|:.:.  .:|...:.     .|:|.:|:.:.|.|..:.:.|.||:
Mouse   305 DTDYQMTKKDMGFTEEE-----FKRLNINAAKSSFLPEEEKKELLER 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-A	NP_524130.1	A_deaminase_N	54..139	CDD:285627
		adm_rel	66..538	CDD:273620	73/307 (24%)
		ADGF	119..531	CDD:238646	73/307 (24%)
Ada	NP_001258981.1	ADA	8..336	CDD:238645	69/295 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2696
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.760