DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-B and Adgf-A2

DIOPT Version :9

Sequence 1:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_525020.2	Gene:	Adgf-A2 / 64879	FlyBaseID:	FBgn0043025	Length:	561	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	195/530 - (36%)
Similarity:	283/530 - (53%)	Gaps:	40/530 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HVAIS---CRRALTK-C-AKIGHTTVSVSRSLRKLSPTAFKTLRQAIAKVGHLNIMGQKIRLNDR 65
            ||||:   |...|.. | |.:|....:::      |......|||...:......:|.::.|:..
  Fly    47 HVAIAVMLCVMVLVLICSAPLGENMSNLT------SEERHARLRQIYIEKERRQRLGSRMGLSPL 105

  Fly    66 ELAANKVIMAVKKEEISKGIL------DPSQFTPGQHIFKTLAEVQKSPIFNLIKGMPKGGALHA 124
            |..||..:||:::.:.....|      .|..|....:|..|       .::..:|.|||||.||.
  Fly   106 EEEANDRLMAIRQVDEEFYNLWRNYHSQPPPFLKHLNIIDT-------NLYAALKSMPKGGLLHV 163

  Fly   125 HDTALCSTDYLISLTYRKNLWIC-TAEEGCKAIAFRFSKEEPKEKPVK--ESIWEPMEEFRERRG 186
            ||:.:...:.||.|.||.|||:| ..|:..:  .||||:..|...|.:  :..|..|..|.:...
  Fly   164 HDSGMLRMEILIDLIYRDNLWVCVNLEQDFE--DFRFSRYFPHIPPAEDYQCNWMLMSNFFQLES 226

  Fly   187 ----EENVTKYLTRRFSMYPFSKFISNNQAWAHFMGIFILLDGLLCHAPIWAEYYYNALKEFAED 247
                |..:.|.||.|...|.     |:::...|......::.||:...|||:|:.:..|.:|..|
  Fly   227 RLEFENRLRKTLTVRPEGYK-----SSSELARHLRRHQRIIHGLITFRPIWSEFIFTMLSDFYAD 286

  Fly   248 GVQYLELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPDFIGSKLIYAPLRGVEPSVVEQ 312
            ||.|:||||.||.:|.:||:..||.:|.....|....|:....||||.||||||.|.:..|.:::
  Fly   287 GVHYVELRSSLPNMYDLDGNNFTILETAEALVSVSNIFKNSFKDFIGIKLIYAPSRNLNDSRMDE 351

  Fly   313 YVKTAVELNKEFPNFMVGFDL-VGQEELGRPLIDFVEPLLKMPEHINFYFHAGETNW-FGSPIDE 375
            |::.|..|...||||..|||| ...:|...||::.|..||::.::|:|||||||:.. ..|..|.
  Fly   352 YLENARLLKLHFPNFFAGFDLNTFGDECNLPLLENVTQLLRIGKNIDFYFHAGESRCPDSSRPDA 416

  Fly   376 NLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANV 440
            ||::|:||.:||||:...:..||.:|::.|.|.||:|:||:||..||...|:|.||||.|:||..
  Fly   417 NLLEALLLQSKRIGNAVNLPFHPEIMKVMKRLSIAVEICPLSNHYLQYFNDFRQHPAAYLIAAGF 481

  Fly   441 PIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGEEKRVGYRKWQE 505
            ||||.||.|.||:.|||:.|||.||:|:.....|||.||..|:||..:|:|...||.:...|||.
  Fly   482 PIVIGSDYPCFWNSAPLTDDFYVAFVGVISGWGDLRLLKQFALNSFLFSSLSETEKNMAVSKWQC 546

  Fly   506 KWDKWIDDVV 515
            .|::|:.::|
  Fly   547 SWNRWVRNLV 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627	16/82 (20%)
		adm_rel	56..515	CDD:273620	181/473 (38%)
		ADGF	93..507	CDD:238646	169/422 (40%)
Adgf-A2	NP_525020.2	A_deaminase_N	52..152	CDD:285627	21/112 (19%)
		adm_rel	83..556	CDD:273620	184/486 (38%)
		ADGF	135..548	CDD:238646	170/426 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469131
Domainoid	1	1.000	52	1.000	Domainoid score	I2828
eggNOG	1	0.900	-	-		E1_COG1816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850