DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-B and ada2b

DIOPT Version :9

Sequence 1:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_687719.2	Gene:	ada2b / 559295	ZFINID:	ZDB-GENE-041210-77	Length:	501	Species:	Danio rerio

Alignment Length:	469	Identity:	187/469 - (39%)
Similarity:	286/469 - (60%)	Gaps:	23/469 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LNIMGQKIRLNDRELAANKVIMAVKKEEISKGILDPSQFTPGQHIFKTLAEVQKSPIFNLIKGMP 117
            |..:|..:.||:.|...:.::..:|.:||:   |.|  |.|..|.||....:|:||||.|::.||
Zfish    42 LQQIGGNMELNEAEKRMDSLLYMLKMKEIT---LSP--FPPANHFFKVRHIIQQSPIFKLLQKMP 101

  Fly   118 KGGALHAHDTALCSTDYLISLTYRKNLWICTAEEGCKAIAFRFSKEEPKEKPVKESIWEPMEEFR 182
            ||.|||.|::|:.|.|:|::.|||.|.:||...:|  ::.|.||...|..: ...|.|:.::..|
Zfish   102 KGAALHIHNSAMVSVDWLLNATYRPNCYICFTWDG--SVRFMFSTSTPFPR-WGCSFWKRLDILR 163

  Fly   183 ERRGEENVTKY---LTRRFSMY---PFSKFISNNQAWAHFMGIFILLDGLLCHAPIWAEYYYNAL 241
            ...|:  ||.:   |.|..:::   |.:.:.:.:..|..|..|||.|.||:.:||:..::.|..|
Zfish   164 ASLGD--VTSFDNSLMRNLTLFTEDPETSYPTQDYIWKRFEKIFIALSGLITYAPVLKDHIYQGL 226

  Fly   242 KEFAEDGVQYLELRSLLPPLYCIDGDMLTIRD---TVAIYNSELERFRADHPDFIGSKLIYAPLR 303
            ||..||.:.|:|||......|.:||   |..|   |:.:|.:..|:|||:||||||:::|.:..|
Zfish   227 KELYEDNIMYVELRIGQAKAYELDG---TTHDRAWTIEVYRNITEQFRANHPDFIGTRVILSAHR 288

  Fly   304 GVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELGRPLIDFVEPL-LKMPEHINFYFHAGETN 367
            ....|.|:|.|:.|:|:.:::|..:.||||||:|:.|..:..|.:.| |.....:.::||||||:
Zfish   289 SSSVSRVKQAVQEAIEMQRKYPEIVAGFDLVGREDTGGSIWYFRDALSLPSESQLPYFFHAGETD 353

  Fly   368 WFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHPA 432
            ..|:.:|.|::||:|..|.|||||:||..||:..:|::...:|:|:||:|||||:|..|.|||||
Zfish   354 LDGTDVDRNVLDALLFNTSRIGHGFAIVHHPVAKQLSRSRRVAVELCPISNQVLKLVSDLRNHPA 418

  Fly   433 ALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGEEKR 497
            |:|::...|:|:||||||.:....||:|||..|:||..:.|:|..||.|||||||||:|..:.:.
Zfish   419 AVLMSDGHPMVVSSDDPSLFGTTGLSYDFYEVFVGIGGLSANLGTLKELAINSIRYSSLSAQLQD 483

  Fly   498 VGYRKWQEKWDKWI 511
            .....|||||:.:|
Zfish   484 KAMTVWQEKWNTFI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627	20/59 (34%)
		adm_rel	56..515	CDD:273620	186/466 (40%)
		ADGF	93..507	CDD:238646	173/423 (41%)
ada2b	XP_687719.2	adm_rel	45..499	CDD:273620	186/466 (40%)
		A_deaminase_N	<46..97	CDD:285627	19/55 (35%)
		ADGF	77..493	CDD:238646	173/423 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595064
Domainoid	1	1.000	269	1.000	Domainoid score	I1799
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2141
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		mtm6590
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770