Protein Alignment Adgf-B and ADA2

DIOPT Version :10

• Sequence 1: NP_649006.2
• Gene: Adgf-B / 39975
• FlyBaseID: FBgn0036751
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001269154.1
• Gene: ADA2 / 51816
• HGNCID: 1839
• Length: 511
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 188/473 - (39%)
• Similarity: 288/473 - (60%)
• Gaps: 24/473 - (5%)

  Fly    56 MGQKIRLNDRELAANKVIMAVKKEEISKGILDPSQFTPGQHIFKTLAEVQKSPIFNLIKGMPKGG 120
            :|.::.||.:|..||:.:|.:|..|: |..:....|.|..|.|:....:::|.:||:::.||||.
Human    46 LGGRLVLNTKEELANERLMTLKIAEM-KEAMRTLIFPPSMHFFQAKHLIERSQVFNILRMMPKGA 109

  Fly   121 ALHAHDTALCSTDYLI-SLTYRKNLWICTAEEGCKAIAFRFSKEEPKEKPVKESIWEPMEEFRER 184
            |||.||..:.:.|:|: ::|||.:..||....|.....|......|.||..|   |..:|::|:|
Human   110 ALHLHDIGIVTMDWLVRNVTYRPHCHICFTPRGIMQFRFAHPTPRPSEKCSK---WILLEDYRKR 171

  Fly   185 RGEENVTKY---LTRRFSM---YPFSKFISNNQAWAHFMGIFILLDGLLCHAPIWAEYYYNALKE 243
              .:|||::   |.|.|::   :|...:.:.|..|:.|..||..:.||:.:||::.:|.:.:::|
Human   172 --VQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSMQE 234

  Fly   244 FAEDGVQYLELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPDFIGSKLIYAPLRGVEPS 308
            |.||.|.|:|:|:.|.|:|.:.|:......:|..|....::|...||:|||.|:||:..|..:.:
Human   235 FYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRSKDVA 299

  Fly   309 VVEQYVKTAVELNKEFPNFMVGFDLVGQEELGRPLIDFVEPLL-------KMPEHINFYFHAGET 366
            |:.:.::.|:.|..:||..:.||||||.|:.|..|.|:.|.|:       |:|    ::||||||
Human   300 VIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLP----YFFHAGET 360

  Fly   367 NWFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHP 431
            :|.|:.||.|::||::|.|.|||||:|::|||.:...:....|.|||||:|||||:|..|.||||
Human   361 DWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHP 425

  Fly   432 AALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGEEK 496
            .|.|:|...|:|||||||:.:....||:|||..|:||..||||||.||.||:|||:||.|:..||
Human   426 VATLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEK 490

  Fly   497 RVGYRKWQEKWDKWIDDV 514
            ......|:::|||:|.||
Human   491 NTFMEIWKKRWDKFIADV 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-B	NP_649006.2	adm_rel	56..515	CDD:273620	188/473 (40%)
ADA2	NP_001269154.1	adm_rel	30..509	CDD:273620	188/473 (40%)
		Dimerization	30..100		15/54 (28%)
		PRB domain	127..185		19/62 (31%)