DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-B and adal-1

DIOPT Version :9

Sequence 1:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_871955.2	Gene:	adal-1 / 259441	WormBaseID:	WBGene00016632	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	87/384 - (22%)
Similarity:	135/384 - (35%)	Gaps:	95/384 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KGMPKGGALHAHDTALCSTDYLISLTYRKNLWICTAEEGCKAIAFRFSKEEPKEKPVKESIWEPM 178
            |.||| ..||||.:...|.:.:                                |.:.||
Worm    57 KNMPK-VELHAHLSGSLSPETI--------------------------------KLIMES----- 83

  Fly   179 EEFRERRGEENVTKY-------LTRRFSMYPFSKFISNNQAWAHFMGIFILLDGLLCHAPIWAEY 236
               .|.|.||.:.||       :|..|..:|                   ::..:|.........
Worm    84 ---DETRAEEIMKKYKLEKPENMTGVFDCFP-------------------VIHAILRKPEAIRIA 126

  Fly   237 YYNALKEFAEDGVQYLELRSLLPPLYCIDGDMLTIRDTVAIYNSELERFRADHPDF--IGSKLIY 299
            ....:|||.||...|||||:  .|.   :.|.:|..|.:.:.   :|.|.|...:|  |.:.||.
Worm   127 IRQTIKEFEEDNCVYLELRT--SPK---ETDFMTYEDYLQVC---IESFEAAKHEFPRIKTFLIV 183

  Fly   300 APLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEEL-GRPLIDFVEPLLKMPEHINFYFHA 363
            :..|.: |.....::...:...::..|.:||.:|.|...| ||.|:.......:. ..:....|.
Worm   184 SLDRRM-PFETAAHILGLIGEAQQRTNVIVGVELSGDPHLDGRRLLKLFVAARRF-HGLGITIHL 246

  Fly   364 GETNWFGSPIDENLVDA---ILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGV 425
            .|       :.:|:.|.   :.|...|||||..:...|....|.....|.:|:|..||...:...
Worm   247 AE-------VLQNMADVEDYLNLRPDRIGHGTFLHTDPYTEYLTNKYKIPLEICLSSNVYSKTTT 304

  Fly   426 DYRNHPAALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAIN 484
            :|||..........||:.|.:||......|.|:.::|.|.:..     ||...:.:.||
Worm   305 NYRNSHFNYWRKRGVPVFICTDDKGVIPGATLTEEYYKAAITF-----DLSTEELIGIN 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627
		adm_rel	56..515	CDD:273620	87/384 (23%)
		ADGF	93..507	CDD:238646	87/384 (23%)
adal-1	NP_871955.2	ADA_AMPD	59..379	CDD:238250	86/382 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810