DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-B and Ampd1

DIOPT Version :9

Sequence 1:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001028475.2	Gene:	Ampd1 / 229665	MGIID:	88015	Length:	745	Species:	Mus musculus

Alignment Length:	392	Identity:	87/392 - (22%)
Similarity:	140/392 - (35%)	Gaps:	112/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 EENVT-KYLTRRFSMYP----------------FSKFISNNQAW-----AHFMGIFILLDGLLCH 229
            |:::| |.|..:.:|:|                |.:|...|..:     :....:::..|..
Mouse   334 EKSLTLKELFAKLNMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNY--- 395

  Fly   230 APIWAEYYYNALKEFAEDGV----QYLELRSLL----PP-------------LYCIDGDMLTIRD 273
              |..||:...:||...|.|    |:.|.|..:    |.             :||  .:|..:..
Mouse   396 --INGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWNKLSSWFVCNRIYC--PNMTWMIQ 456

  Fly   274 TVAIYNSELERFRADH--PDFIGSKL--IYAPLRGVEPSVVEQ-YVKTAVELNKEFPNFMVGFDL 333
            ...||    :.||:.:  |.| |..|  |:.|:  .|.::..| :...:|     |...:.|||.
Mouse   457 VPRIY----DVFRSKNFLPHF-GKMLENIFLPV--FEATINPQAHPDLSV-----FLKHITGFDS 509

  Fly   334 VGQE----------ELGRP--------------------LIDFVEPLLKMPEHINFYF--HAGET 366
            |..|          :..:|                    .|..:..|.|......|.|  |.||.
Mouse   510 VDDESKHSGHMFSSKSPKPEEWTMENNPSYTYYAYYMYANITVLNSLRKERGMNTFLFRPHCGEA 574

  Fly   367 NWFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSNQVLQLGVDYRNHP 431
            ...     .:|:.|.:: ...|.||..:.|.|::..|..|..|.|.:.|:||..|.|  :|..:|
Mouse   575 GAL-----THLMTAFMI-ADNISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFL--EYAKNP 631

  Fly   432 AALLLAANVPIVISSDDPSFWHCA--PLSHDFYFAFLGIAPMKADLRFLKSLAINSIRYSALVGE 494
            ....|...:.|.:|:|||..:|..  ||..::..|   ....|.....:..:|.||:....:..|
Mouse   632 FLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIA---AQVFKLSTCDMCEVARNSVLQCGISHE 693

  Fly   495 EK 496
            ||
Mouse   694 EK 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627
		adm_rel	56..515	CDD:273620	87/392 (22%)
		ADGF	93..507	CDD:238646	87/392 (22%)
Ampd1	NP_001028475.2	PLN03055	129..740	CDD:178613	87/392 (22%)
		AMPD	238..734	CDD:238644	87/392 (22%)
		Substrate binding. /evidence=ECO:0000250	372..377		1/4 (25%)
		Substrate binding. /evidence=ECO:0000250	648..651		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810